Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions

Lewis, B. J.; Rajpara, Sanjay; Haggart, A. M.; Barker, Robert N.; Ormerod, AD

doi:10.1111/cei.12086

Cited by 23 publications

(24 citation statements)

References 44 publications

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“…Th17 cells and IL-17 mRNA expression are increased in the dermis of psoriasis affected skin [11], while IL-17A is found in significantly higher levels in lesional psoriasis as compared with nonlesional skin and healthy controls [12]. Comparison of the CD4 + Th cell population from psoriasis lesions ex vivo against peripheral blood samples from the same patients found over-representation of Th17 cells [13].…”

Section: Il-17 Inhibitorsmentioning

confidence: 99%

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Yiu

Warren

2015

Immunotherapy

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Psoriasis is a common chronic inflammatory disease of the skin. Current biologic therapies are highly effective in the treatment of psoriasis, transforming the lives of patients with this significantly disabling disease. Advances in the understanding of the immunological pathogenesis of psoriasis have led to the development of new biologic therapies, targeting specific inflammatory cytokines upregulated in psoriasis. These include the IL-17 antagonists, secukinumab, brodalumab and ixekizumab; the IL-23 antagonists, guselkumab and tildrakizumab; and the oral small molecule therapies, tofacitinib and apremilast. Here, we review evidence for the efficacy and safety of these novel psoriasis therapies, providing clinicians with an overview of the next era in immunotherapy for psoriasis.

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Section: Il-17 Inhibitorsmentioning

confidence: 99%

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Yiu

Warren

2015

Immunotherapy

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“…However, the fact that psoriasis is a Th 1 autoimmune disorder is well known from the first evidence, since 2004. Nevertheless, more recently, several authors have already suggested that Th 1 cells may not be as centrally involved as originally thought …”

Section: Discussionmentioning

confidence: 92%

TNF‐α inhibitors reduce the pathological Th₁–Th₁₇/Th₂ imbalance in cutaneous mesenchymal stem cells of psoriasis patients

Campanati

Orciani

Lazzarini

et al. 2016

Experimental Dermatology

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Psoriasis is a disease characterized by an imbalance between Th and Th and Th inflammatory axes, in which cutaneous mesenchymal stem cells (MSCs) are early involved, as they show a greater relative expression of several genes encoding for Th and Th cytokines. Therapeutic implications of TNF-α inhibitors on differentiated skin cells have been largely described in psoriasis; however, their effects on MSCs derived from patients with psoriasis have been only partially described. The aim of this work was to evaluate the effect of TNF-α inhibitors on cytokine milieu expressed by MSCs isolated from the skin of patients with psoriasis. Resident MSCs from skin of patients with psoriasis and healthy subjects have been isolated, characterized and profiled by PCR and ELISA for the expression of 22 cytokines involved in Th , Th and Th pathways, both before and after 12 weeks therapy with TNF-α inhibitors. The administration of TNF-α inhibitors for 12-weeks acts on MSCs as follows: it reduces the expression of several Th -Th cytokines whose levels are elevated at baseline (IL-6, IL-8, IL-12, IL-23A, IFN-γ, TNF-α, CCL2, CCL20, CXCL2, CXCL5, IL-17A, IL-17C, IL-17F, IL-21, G-CSF). Similarly, it enhances the expression of several Th cytokines which are underexpressed at baseline (IL-2, IL-4, IL-5), reducing the expression of those overexpressed at baseline (TGF-β and IL-13). TNF-α inhibitors could contribute to reduce the pathological imbalance between the Th -Th vs Th axis in MSCs of patients with psoriasis.

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“…The IL-23/IL-17 axis plays a crucial role in the inflammatory and proliferative pathway of both psoriatic skin and joint tissues [33] . Moreover, IL-17 serum levels in psoriatic patients have been shown to be increased compared to healthy controls [59] and T H 17 cell levels were higher in psoriatic plaques than in controls [60] .…”

Section: The Il-23/il-17 Axismentioning

confidence: 98%

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

Granata

Skarmoutsou²,

Trovato³

et al. 2016

Pathobiology

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Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases. In this review, we present an overview of the roles of adipokines, cytokines, and microRNAs in the pathogenesis and the progression of these three diseases.

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Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions

Abstract: SummaryRecent evidence points to the T helper type 17 (Th17) subset as key in the pathogenesis of psoriasis, but cells of this type in lesions remain to be fully characterized. Here we isolated, enumerated, functionally tested and clonotyped the CD4

Cited by 23 publications

References 44 publications

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

TNF‐α inhibitors reduce the pathological Th₁–Th₁₇/Th₂ imbalance in cutaneous mesenchymal stem cells of psoriasis patients

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

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Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions

Abstract: SummaryRecent evidence points to the T helper type 17 (Th17) subset as key in the pathogenesis of psoriasis, but cells of this type in lesions remain to be fully characterized. Here we isolated, enumerated, functionally tested and clonotyped the CD4

Cited by 23 publications

References 44 publications

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

TNF‐α inhibitors reduce the pathological Th1–Th17/Th2 imbalance in cutaneous mesenchymal stem cells of psoriasis patients

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

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TNF‐α inhibitors reduce the pathological Th₁–Th₁₇/Th₂ imbalance in cutaneous mesenchymal stem cells of psoriasis patients