1989
DOI: 10.1016/s0140-6736(89)90314-0
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Predominance of Borrelia Burgdorferi Specific B Cells in Cerebrospinal Fluid in Neuroborreliosis

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Cited by 47 publications
(20 citation statements)
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“…ELISPOT assays employing microtitre plates with nitrocellulose bottoms (see above) were adopted (Baig et al ., 1989). The wells were coated with 100 μl aliquots per well of antigen MAG, MBP and PO at a final concentration of 10 μg/ml, and MAG peptides at 5 μg/ml.…”
Section: Methodsmentioning
confidence: 79%
“…ELISPOT assays employing microtitre plates with nitrocellulose bottoms (see above) were adopted (Baig et al ., 1989). The wells were coated with 100 μl aliquots per well of antigen MAG, MBP and PO at a final concentration of 10 μg/ml, and MAG peptides at 5 μg/ml.…”
Section: Methodsmentioning
confidence: 79%
“…The intrathecal expansion or in- crease in relative size of the B-cell pool is clinically important because B-cells usually are negligible in normal CSF and the high percentage of CSF B-cells in severe OMS indicates pronounced recruitment to the CNS. 30 The next step will be to determine if CSF B-cells in OMS are highly activated and lead to a humoral response that is pathogenic. 6,12,13 However, autoreactive B-cells also may contribute to autoimmune disease merely by enhancing antigen presentation to T-cells.…”
Section: Results Distribution Of Lymphocyte Population In Csfmentioning
confidence: 99%
“…Neurologic manifestations of Lyme disease include meningitis, facial nerve palsy, cranial neuritis, motor or sensory radiculoneuritis, or subtle encephalitis [1]. Disease may be due, in part, to presence of the causative spirochete, Borrelia burgdorferi , within the nervous system, the virulence of particular organisms, and the host immune response to the pathogen [2–5]. Antibodies to the B. burgdorferi flagellin, elicited during the course of infection, have been shown to bind to human axons and therefore may be implicated in the pathogenesis of neurologic disease [1, 2, 6].…”
Section: Introductionmentioning
confidence: 99%
“…Disease may be due, in part, to presence of the causative spirochete, Borrelia burgdorferi , within the nervous system, the virulence of particular organisms, and the host immune response to the pathogen [2–5]. Antibodies to the B. burgdorferi flagellin, elicited during the course of infection, have been shown to bind to human axons and therefore may be implicated in the pathogenesis of neurologic disease [1, 2, 6]. The specificity of these cross‐reactive antibodies has been mapped to a 12‐amino acid (aa) epitope (aa 213–24) in the central region of the B. burgdorferi flagellin [7].…”
Section: Introductionmentioning
confidence: 99%