Predominance of left‐sided deep vein thrombosis and body weight

Thijs, Willemien; Rabe, Klaus F.; Rosendaal, Frits R.

doi:10.1111/j.1538-7836.2010.03967.x

Cited by 40 publications

(30 citation statements)

References 12 publications

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“…It has been speculated that the percent of DVTs due to MTS may be much higher than clinically recognized. This suspicion is supported by the disproportionately greater incidence of left‐sided DVT, clinical studies that report significant iliac venous compression occurs in the majority of patients with left DVT, and presence of fibrous spurs in 22% to 33% of cadavers . However, no population‐based studies have yet been conducted to document the prevalence or incidence of MTS.…”

Section: Possible Underestimation Of Contribution Of Mts To the Populmentioning

confidence: 99%

May‐Thurner syndrome: History of understanding and need for defining population prevalence

Harbin

Lutsey

2020

Journal of Thrombosis and Haemostasis

103

100

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Patients with May‐Thurner syndrome (MTS) are at elevated risk of developing an extensive left iliofemoral deep vein thrombosis (DVT; localized blood clot) due to an anatomical variant where the right common iliac artery compresses the left common iliac vein against the lumbar spine. While MTS was initially presumed to be rare when it was first anatomically defined in 1957, case reports of this syndrome have recently become more frequent, perhaps due to improved imaging techniques allowing for enhanced visualization of the iliac veins. Still, the population burden of this condition is unknown, and there is speculation it may be higher than generally perceived. In the present review, we (a) review history of how MTS became recognized, (b) describe practical challenges of studying MTS in population‐based settings due to the specialized imaging required for diagnosis, (c) discuss why the contribution of MTS to DVT may be underestimated, (d) describe uncertainty regarding the degree of venous compression which leads to DVT, and (e) outline future research needs. Our goal is to raise awareness of MTS and spark additional research into the epidemiology of this condition, which may be an underappreciated causative venous thromboembolism risk factor.

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Section: Possible Underestimation Of Contribution Of Mts To the Populmentioning

confidence: 99%

May‐Thurner syndrome: History of understanding and need for defining population prevalence

Harbin

Lutsey

2020

Journal of Thrombosis and Haemostasis

103

100

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“…The underlying reason is the compression of the V. iliaca communis sinistra by the overcrossing A. iliaca communis dextra. (Aumüller, 2007;Schünke, Schulte, & Schumacher, 2015;Thijs, Rabe, Rosendaal, & Middeldorp, 2010;Virchow, 1851) We detected increased circumference in the right upper leg, which could also be due to the impaired venous drain. | 2019 | ISSUE -| VOLUME --© 2019 University of Alicante Swollen legs are a common issue in long runs and probably a result of increased fluid intake and subsequent edema.…”

Section: Discussionmentioning

confidence: 59%

Significant effusion in the joints of the lower extremity after running an ultramarathon in extreme conditions

Steinmetz

Höller

Hubert

et al. 2019

jhse

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Introduction:The "Brocken challenge" ultramarathon takes place in the cold of February over 80 km with 1,900 m of elevation change. The purpose of this study was to evaluate the effects of an ultramarathon under extreme conditions on the lower extremities. Methods: Out of the 182 starters, 44 athletes were included into the study (n=44). We examined these athletes using a questionnaire, by measuring circumferences of their lower extremities and by standardized sonographic measurement of joint effusion of knee and ankle joints before and after the run. Results: After the run, the right leg and both feet significantly increased in circumference. Knee joints on both sides and the left ankle joint showed significantly more effusion after the run (right knee: 84%, right ankle: 43%; left knee: 80%, left ankle: 48%). Heavier and less trained athletes showed significantly more effusion in sonographic assessment of the knee and ankle. Neither swelling, nor effusion had a measurable influence on finishing time. Conclusions: Running an ultramarathon in the cold overloads the fluid draining capacity in the muscles and joints of the legs especially in heavier and less trained athletes without measurable immediate effect on performance.

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“…MTS is defined as an extrinsic compression of the left common iliac vein by the right common iliac artery against the lumbar vertebra. It classically presents as an unprovoked left‐sided acute iliofemoral DVT among women aged in their 30s to 50s (women to men ratio of 2:1) …”

Section: Discussionmentioning

confidence: 99%