Predominance of Leptospira wolffii in north-central Bangladesh, 2019

Rahman, Shahriar; Paul, Shyamal Kumar; Aung, Meiji Soe; Ahmed, Salma; Haque, N; Raisul, M.N.I.; Choity, J.K.; Nila, S S; Ara, H; Roy, Samarjit; Khan, M.N.A.A.; Hossain, Md. Akram; Kobayashi, Nobumichi

doi:10.1016/j.nmni.2020.100765

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…L. fainei has been reported to cause disease in humans ( 20 ) but was not isolated from any human patient or bovid in this study. L. venezuelensis is phylogenetically closer to other intermediate species reported to cause human illness, such as L. liceraciae ( 21 ) and L. wolffi ( 22 ) and is phylogenetically close to Leptospira spp. isolated from environmental samples in Malaysia, Mayotte, and New Caledonia ( 5 ).…”

Section: Discussionmentioning

confidence: 98%

Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans–Endemic Region, Venezuela

Caraballo,

Rangel,

Reyna-Bello

et al. 2024

Emerg. Infect. Dis.

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Leptospirosis is a common but underdiagnosed zoonosis. We conducted a 1-year prospective study in La Guaira State, Venezuela, analyzing 71 hospitalized patients who had possible leptospirosis and sampling local rodents and dairy cows. Leptospira rrs gene PCR test results were positive in blood or urine samples from 37/71 patients. Leptospira spp. were isolated from cultured blood or urine samples of 36/71 patients; 29 had L. interrogans, 3 L. noguchii , and 4 L. venezuelensis . Conjunctival suffusion was the most distinguishing clinical sign, many patients had liver involvement, and 8/30 patients with L. interrogans infections died. The Leptospira spp. found in humans were also isolated from local rodents; L. interrogans and L. venezuelensis were isolated from cows on a nearby, rodent-infested farm. Phylogenetic clustering of L. venezuelensis isolates suggested a recently expanded outbreak strain spread by rodents. Increased awareness of leptospirosis prevalence and rapid diagnostic tests are needed to improve patient outcomes.

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Section: Discussionmentioning

confidence: 98%

Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans–Endemic Region, Venezuela

Caraballo,

Rangel,

Reyna-Bello

et al. 2024

Emerg. Infect. Dis.

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Epidemiological Features of Leptospirosis and Identification of Leptospira wolffii as a Persistently Prevailing Species in North–Central Bangladesh

Sultana,

Paul,

Nasreen

et al. 2024

Infectious Disease Reports

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Leptospirosis is considered to be the most widespread, yet neglected, re-emerging zoonotic disease caused by infection with a pathogenic species of the genus Leptospira. Although this disease is prevalent in Bangladesh, the recent epidemiological status has not yet been well documented. In this study, we aimed to determine the prevalence of leptospirosis among febrile patients using different diagnostic methods and to characterize the epidemiological features and species of Leptospira in Mymensingh, north–central Bangladesh. Among the blood samples of 186 patients with suspected leptospirosis who met the inclusion criteria, including having a fever for more than 5 days (November 2021–June 2022), 88 samples (47%) were Leptospira-positive according to IgM LAT, IgM ELISA, or nested PCR (positivity rates: 38%, 37%, and 42%, respectively). Nested PCR showed a significantly higher positivity rate (54%) in patients with a short fever (5–10 day) than the other methods did, with lower rates among those with a longer fever. Leptospirosis cases were more common in males (68%), those 16–45 years of age (70%), residents of rural areas (81%), and farmers (41%). In addition to a fever, myalgia and jaundice were found in more than 70% of the patients, while variable symptoms were observed. The 16S rRNA sequencing analysis revealed that the Leptospira species in all the 22 samples tested were L. wolffii, belonging to the pathogenic subclade P2. This study showed the recent epidemiological features of leptospirosis in Bangladesh, indicating the presumptive predominance of L. wolffii since 2019.

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Predominance of Leptospira wolffii in north-central Bangladesh, 2019

Cited by 2 publications

References 12 publications

Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans–Endemic Region, Venezuela

Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans–Endemic Region, Venezuela

Epidemiological Features of Leptospirosis and Identification of Leptospira wolffii as a Persistently Prevailing Species in North–Central Bangladesh

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