Predominance of t cells in the lymphocytic infiltrates of synovial tissues in rheumatoid arthritis

Bankhurst, Arthur D.; Husby, Gunnar; Williams, Ralph C.

doi:10.1002/art.1780190307

Cited by 81 publications

(23 citation statements)

References 23 publications

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“…PCs in RA synovium have been reported to synthesize high amounts of Igs, including rheumatoid factor, which is thought to participate in the pathogenesis of tissue damage (6,(15)(16)(17). Moreover, rheumatoid synoviocytes are reported to support the terminal differentiation of B cells into mature PCs in vitro (18).…”

Section: Discussionmentioning

confidence: 99%

Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients

Shi

Hayashida

Kaneko

et al. 2001

The Journal of Immunology

251

193

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A unique feature in inflammatory tissue of rheumatoid arthritis (RA) is the formation of ectopic lymphoid aggregates with germinal center (GC)-like structures that can be considered to contribute to the pathogenesis of RA, because local production of the autoantibody, rheumatoid factor, is thought to be a causative factor in tissue damage. However, the factors governing the formation of GC in RA are presently unknown. To begin to address this, the expression of B cell attracting chemokine (BCA-1) (CXCL13), a potent chemoattractant of B cells, was examined in the synovium of patients with RA or with osteoarthritis (OA). Expression of BCA-1 mRNA was detected in all RA samples, but in only one of five OA samples. Lymphoid follicles were observed in four of seven RA samples and in two of eight OA samples, and in most of them BCA-1 protein was detected in GC. BCA-1 was not detected in tissues lacking lymphoid follicles. Notably, BCA-1 was detected predominantly in follicular dendritic cells in GC. CD20-positive B cells were aggregated in regions of BCA-1 expression, but not T cells or macrophages. These data suggest that BCA-1 produced by follicular dendritic cells may attract B cells and contribute to the formation of GC-like structures in chronic arthritis.

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Section: Discussionmentioning

confidence: 99%

Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients

Shi

Hayashida

Kaneko

et al. 2001

The Journal of Immunology

251

193

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“…Infiltration of the synovium by antibody-secreting plasma cells is a characteristic feature of the disease (3,4). This local production of antibody is thought to participate in the pathogenesis of RA, although the exact mechanism(s) of tissue injury remains unclear (2).…”

Section: Introductionmentioning

confidence: 99%

Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.

Bridges¹,

Lee²,

Johnson³

et al. 1995

J. Clin. Invest.

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Immunoglobulin secretion by plasma cells infiltrating syno-_ vial membranes is a prominent feature of RA. Previous analyses of a cDNA library generated from synovium of RA patient BC revealed immunoglobulin K light chain transcripts with extensive somatic mutation, frequent N region addition, and unexpected variation in the lengths of CDR3 regions which form the center of the antigen binding site. To determine if these characteristics are present in other individuals, we performed reverse transcription-polymerase chain reaction amplification and sequenced -10 VKcontaining amplicons from nine tissue samples: synovia of three individuals with long-standing RA (including patient BC), PBLs of two of these individuals, and PBLs or splenocytes of four normal individuals. Increased levels of somatic mutation in PBLs appeared to correlate with increased age, which may reflect accumulation of circulating memory cells and/or decreased bone marrow production of naive B lymphocytes. Two of three RA synovial samples and both RA PBL samples exhibited increased proportions of clones with unusual CDR3 lengths. Enrichment for these antibody binding sites could be due to abnormal regulation of the emerging repertoire or to selection for B lymphocytes bearing antibodies of unusual specificity, and may play a role in the pathogenesis of RA. (J. Clin. Invest. 1995.96:831-841.)

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“…Most RA synovial lymphocytes are in fact T cells (21,22), and a large number of them bear surface markers indicating that they have been activated in vivo (23)(24)(25). The linkage of RA to specific class II MHC epitopes that control antigen presentation to T cells (26)(27)(28) implies a key role for T cells and perhaps for T cell responses to a particular antigen.…”

Section: Introductionmentioning

confidence: 99%

Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen.

Fox

Millard

et al. 1990

J. Clin. Invest.

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Accumulating evidence implicates a central role for synovial T cells in the pathogenesis of rheumatoid arthritis, but the activation pathways that drive proliferation and effector function of these cells are not known. We have recently generated a novel monoclonal antibody against a rheumatoid synovial T cell line that recognizes an antigen termed UM4D4 (CDw6O). This antigen is expressed on a minority of peripheral blood T cells, and represents the surface component of a distinct pathway of human T cell activation. The current studies were performed to examine the expression and function of UM4D4 on

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Predominance of t cells in the lymphocytic infiltrates of synovial tissues in rheumatoid arthritis

Cited by 81 publications

References 23 publications

Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients

Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles Within the Synovium of Chronic Arthritis Patients

Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.

Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen.

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