2002
DOI: 10.1124/jpet.300.3.900
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Predominance of δ-Opioid-Binding Sites in the Porcine Enteric Nervous System

Abstract: The antidiarrheal and constipating actions of opioids are mediated in part by enteric neurons, which lie within the wall of the small intestine and colon, but the differential expression of specific, high-affinity opioid-binding sites in ganglionated plexuses within functionally distinct intestinal segments has not been examined. We determined the saturation binding characteristics under Na

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Cited by 12 publications
(10 citation statements)
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“…Previous pharmacological, immunohistochemical, and radioligand binding studies have demonstrated the presence of δ ‐ORs and the relative absence of μ ‐ORs in the mucosa and submucosa of the porcine ileum ( Poonyachoti et al , 2001 ; Townsend & Brown, 2002). Nevertheless, several selective μ ‐OR agonists are quite potent and effective inhibitors of neurogenic ion transport in this tissue preparation.…”
Section: Discussionmentioning
confidence: 97%
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“…Previous pharmacological, immunohistochemical, and radioligand binding studies have demonstrated the presence of δ ‐ORs and the relative absence of μ ‐ORs in the mucosa and submucosa of the porcine ileum ( Poonyachoti et al , 2001 ; Townsend & Brown, 2002). Nevertheless, several selective μ ‐OR agonists are quite potent and effective inhibitors of neurogenic ion transport in this tissue preparation.…”
Section: Discussionmentioning
confidence: 97%
“…Therefore, these μ ‐ORs possess either a tremendous reserve capacity, are expressed in an altered form, or are absent altogether. The low levels of [ 3 H]DAMGO binding and the absence of μ ‐OR‐like immunoreactivity argue against the presence of a large μ ‐OR population ( Poonyachoti et al , 2001 ; Townsend & Brown, 2002). In sum, these functional studies provide evidence for receptors exhibiting the characteristics of both μ ‐ and δ ‐ORs.…”
Section: Discussionmentioning
confidence: 99%
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“…OR are also constitutively expressed in the gut where they are found in the myenteric and submucous plexus [39][40][41][42] and at lower densities in enterocytes [43]. Other non-neuronal locations where opioid binding sites and the expression of OR transcripts have been demonstrated include: endocrine cells [44], vascular endothelial cells [45][46] and smooth muscle [47], and in ce lls of the immune system such as macrophages and lymphocytes, among others [48][49].…”
Section: Anatomical Distribution Of Opioid Receptorsmentioning
confidence: 99%