Predominant cultivable microflora of plaque on removable dentures in patients with denture‐induced stomatitis

Theilade, Else; Budtz-Jørgensen, E

doi:10.1111/j.1399-302x.1988.tb00597.x

Cited by 104 publications

(87 citation statements)

References 39 publications

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“…The presence of prosthetic devices within the oral cavity, such as acrylic dentures, may encourage the carriage of staphylococci. 10 In studies of denture wearing patients, carriage rates of S. aureus have varied from 23-48%. 11,12 In a study of 110 patients attending a dental hospital with a range of oral diseases there was an observed prevalence of S.aureus in saliva of 21% and from gingival swabs of 11%.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus in the oral cavity: a three-year retrospective analysis of clinical laboratory data

Smith¹,

et al. 2003

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Objective A retrospective analysis of laboratory data to investigate the isolation of Staphylococcus aureus from the oral cavity and facial area in specimens submitted to a regional diagnostic oral microbiology laboratory. Methods A hand search of laboratory records for a three-year period (1998)(1999)(2000) was performed for specimens submitted to the regional diagnostic oral microbiology laboratory based at Glasgow Dental Hospital and School. Data were collected from forms where S. aureus was isolated. These data included demographics, referral source, specimen type, methicillin susceptibility and clinical details. Results For the period 1998-2000, there were 5,005 specimens submitted to the laboratory. S. aureus was isolated from 1,017 specimens, of which 967 (95%) were sensitive to methicillin (MSSA) and 50 (5%) were resistant to methicillin (MRSA). The 1,017 specimens were provided from 615 patients. MRSA was isolated from 37 (6%) of patients. There was an increasing incidence of S. aureus with age, particularly in the >70 years age group. The most common specimen from which MSSA was isolated was an oral rinse (38%) whilst for MRSA isolates this was a tongue swab (28%). The clinical condition most commonly reported for MSSA isolates was angular cheilitis (22%). Erythema, swelling, pain or burning of the oral mucosa was the clinical condition most commonly reported for MRSA isolates (16%). Patients from whom the MSSA isolates were recovered were most commonly (55%) seen in the oral medicine clinic at the dental hospital, whilst patients with MRSA were more commonly seen in primary care settings such as nursing homes, hospices and general dental practice (51%). Conclusion In line with more recent surveys, this retrospective study suggests that S. aureus may be a more frequent isolate from the oral cavity than hitherto suspected. A small proportion of the S. aureus isolates were MRSA. There were insufficient data available to

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Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus in the oral cavity: a three-year retrospective analysis of clinical laboratory data

Smith¹,

et al. 2003

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“…The presence of prosthetic devices within the oral cavity, such as acrylic dentures, may encourage carriage of staphylococci [22]. In studies of denture-wearing patients, carriage rates of S. aureus varied from 23% to 48% [23,24].…”

Section: Staphylococci In the Healthy Oral Cavitymentioning

confidence: 99%

“…Other oral infections from which S. aureus has been cultured include infected jaw cysts [38], oral mucosal lesions [23,39] and denture-induced stomatitis [22,40]. More usually, S. aureus infection is associated with angular cheilitis.…”

Section: Staphylococci In Oral Diseasementioning

confidence: 99%

The ecology of Staphylococcus species in the oral cavity

Smith¹,

Jackson²,

Bagg³

2001

Journal of Medical Microbiology

203

168

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“…They also provide a barrier to microorganisms, toxins, and various antigens. Staphylococcus aureus is among the most important human pathogens; this organism causes various superficial and systemic infections and is often implicated in oral mucositis, including angular cheilitis (24,33) and denture-induced stomatitis (47). It is also a leading cause of bacterial keratitis (41) and has been implicated as a causative or exacerbating agent in a broad range of skin diseases, including atopic dermatitis, carbuncles, cellulitis, furuncles, follicles, Kawasaki syndrome, impetigo, psoriasis, and scalded skin syndrome (6, 10-12, 29, 34, 43, 50).…”

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confidence: 99%

Internalization of Staphylococcus aureus by Human Keratinocytes

et al. 2004

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Staphylococcus aureus is among the most important human pathogens and causes various superficial and systemic infections. The ability of S. aureus to be internalized by, and survive within, host cells, such as keratinocytes, may contribute to the development of persistent or chronic infections and may finally lead to deeper tissue infections or dissemination. To examine the mechanisms of internalization of S. aureus by keratinocytes, isogenic mutants lacking fibronectin-binding proteins (FnBPs), a recombinant protein consisting of the fibronectin-binding domain of S. aureus FnBPs, and an anti-␣5␤1 antibody were used in cocultures with immortalized keratinocytes and primary keratinocytes. We found that internalization of S. aureus by immortalized keratinocytes requires bacterial FnBPs and is mediated by the major fibronectin-binding integrin ␣5␤1. In contrast to internalization by immortalized keratinocytes, internalization of S. aureus by primary keratinocytes could occur through FnBP-dependent and -independent pathways. S. aureus clumping factor B (ClfB), which was recently determined to bind to epithelial cells, was not involved in the uptake of this bacterium by keratinocytes. The identification of an alternate uptake pathway, which is independent of S. aureus FnBPs and host cell ␣5␤1, has important implications for the design of therapies targeted to bacterial uptake by host cells.

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Predominant cultivable microflora of plaque on removable dentures in patients with denture‐induced stomatitis

Cited by 104 publications

References 39 publications

Staphylococcus aureus in the oral cavity: a three-year retrospective analysis of clinical laboratory data

Staphylococcus aureus in the oral cavity: a three-year retrospective analysis of clinical laboratory data

The ecology of Staphylococcus species in the oral cavity

Internalization of Staphylococcus aureus by Human Keratinocytes

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