1997
DOI: 10.1016/s0006-8993(96)01472-2
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Predominant expression of Brn-2 in the postmitotic neurons of the developing mouse neocortex

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Cited by 38 publications
(28 citation statements)
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“…1A) (15) (32). In contrast, in the central nervous system, Brn-2 expression appears to be upregulated in postmitotic neurons of the developing mouse neocortex (19). These observations would indicate that Brn-2 expression is regulated, although the nature of the signal transduction pathways operating to target the Brn-2 promoter is not known.…”
Section: Resultsmentioning
confidence: 89%
“…1A) (15) (32). In contrast, in the central nervous system, Brn-2 expression appears to be upregulated in postmitotic neurons of the developing mouse neocortex (19). These observations would indicate that Brn-2 expression is regulated, although the nature of the signal transduction pathways operating to target the Brn-2 promoter is not known.…”
Section: Resultsmentioning
confidence: 89%
“…Rorb belongs to the orphan nuclear receptor family and is preferentially expressed in L4 of the mature neocortex (13,14). Brn1/2 are members of the class III POU (Pit1-Oct1/Oct2-UNC86) domain transcription factors and are preferentially expressed in L2/3 and L5 of the mature neocortex (15)(16)(17). Our detailed analysis of temporal expression profiles of Brn2 and Rorb suggested that UCP neurons initially possess common characteristics and then acquire distinct features.…”
mentioning
confidence: 85%
“…Brn1 expression cannot, therefore, compensate for Brn2 loss in ESCs in contrast to their partially redundant roles in vivo. Secondly, although Brn2 is expressed in ESC-derived radial glial cells in vitro, it is not expressed in radial glial cells of the ventricular zone in the developing cortex, but rather at later stages of differentiation in the sub-ventricular zone (Hagino-Yamagishi et al, 1997).…”
Section: Brn2 Is Upstream Of a Neurogenic Transcriptional Network In mentioning
confidence: 98%
“…Brn2 is expressed in sub-ventricular zone progenitor cells throughout the neuraxis and, upon cell differentiation, is expressed in cortical layers II and III, and in V pyramidal neurons (Hagino-Yamagishi et al, 1997). Brn2-knockout neonates show neuronal loss only in the hypothalamic supraoptic and paraventricular nuclei, where the closely related Brn1 (also known as Pou3f3) is not expressed (Nakai et al, 1995;Schonemann et al, 1995).…”
Section: Introductionmentioning
confidence: 99%