Predominant localization in glial cells of freel-arginine. Immunocytochemical evidence

Aoki, Eiko; Semba, Reiji; Mikoshiba, Katsuhiko; Kashiwamata, Shigeo

doi:10.1016/0006-8993(91)90961-t

Cited by 114 publications

(53 citation statements)

References 14 publications

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“…Therefore, EGCs may represent a major source of L-arginine in the ENS, transferring it to neurons when required. In a similar fashion, in the CNS, L-arginine is predominantly stored within astrocytes (Aoki et al, 1991), which probably play a crucial role in the metabolism and recirculation of arginine and in the regulation of NO signaling (Wiesinger, 2001).…”

Section: Neuroprotective and Neuromodulatory Functions Of Egcmentioning

confidence: 97%

Role of enteric glial cells in inflammatory bowel disease

Cabarrocas

Savidge

Liblau

2002

Glia

160

154

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Enteric glial cells (EGCs) represent an extensive but relatively poorly described cell population within the gastrointestinal tract. Accumulating data suggest that EGCs represent the morphological and functional equivalent of CNS astrocytes within the enteric nervous system (ENS). The EGC network has trophic and protective functions toward enteric neurons and is fully implicated in the integration and the modulation of neuronal activities. Moreover, EGCs seem to be active elements of the ENS during intestinal inflammatory and immune responses, sharing with astrocytes the ability to act as antigen-presenting cells and interacting with the mucosal immune system via the expression of cytokines and cytokine receptors. Transgenic mouse systems have demonstrated that specific ablation of EGC by chemical ablation or autoimmune T-cell targeting induces an intestinal pathology that shows similarities to the early intestinal immunopathology of Crohn's disease. EGCs may also share with astrocytes the ability to regulate tissue integrity, thereby postulating that similar interactions to those observed for the blood-brain barrier may also be partly responsible for regulating mucosal and vascular permeability in the gastrointestinal tract. Disruption of the EGC network in Crohn's disease patients may represent one possible cause for the enhanced mucosal permeability state and vascular dysfunction that are thought to favor mucosal inflammation. GLIA 41:81-93, 2003.

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Section: Neuroprotective and Neuromodulatory Functions Of Egcmentioning

confidence: 97%

Role of enteric glial cells in inflammatory bowel disease

Cabarrocas

Savidge

Liblau

2002

Glia

160

154

View full text Add to dashboard Cite

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“…The neurons which contain only NOS may be provided with arginine, the precursor of NO, from the surrounding astrocytes (AOKI et al, 1991;Pow, 1994). The citrulline which was produced by NOS neurons lacking ASS, and that may diffuse into the extracellular space without recycling to argininosuccinate in their cytosol.…”

Section: Co-localization Of Ass and Nosmentioning

confidence: 99%

Distribution and Co-Localization of Nitric Oxide Synthase and Argininosuccinate Synthetase in the Cat Hypothalamus.

Isayama

Nakamura

Kanemaru

et al. 1997

Archives of Histology and Cytology

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“…Therefore, the localization of these NO-related substances, such as L-arginine, L-citrulline and cGMP, may supply additional information on the sites of NO synthesis and the target cells where NO stimulates guanylate cyclase. L-arginine immunoreactivity in the rat brain and spinal cord is evident mainly in astrocytes including Bergmann glial cells in the cerebellum and processes of astrocytes wrapping vascular endothelial cells and smooth muscle [4] (Fig. 2).…”

Section: IVmentioning

confidence: 99%

“…NO is formed from the terminal guanido nitrogen atoms of L-arginine through the action of NO synthase (NOS, EC) [4,10,11,39], with the stoichiometric production of L-citrulline [45,50,54]. In addition to its substrates L-arginine and O2, NOS requires nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and tetrahydrobiopterin (H4biopterin) as cofactors in order to produce citrulline and NO.…”

Section: Introductionmentioning

confidence: 99%