Predominant loss of the photopic negative response in central retinal artery occlusion

Machida, Shigeki; Gotoh, Yasutaka; Tanaka, Michiko; Tazawa, Yutaka

doi:10.1016/j.ajo.2003.10.023

Cited by 76 publications

(60 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These are large differences between groups, 10 but the magnitude of difference was judged to be plausible based on previous studies. 1,7 No difference in VA was expected because for this to happen, retinal damage would have had to occur selectively at the macula.…”

Section: Sample Size and Statistical Analysismentioning

confidence: 99%

“…However, patients sometimes complain of postoperative transient loss of vision, poor reading, altered perception of colors, and reduced visual acuity (VA) for both near and distance. 1 The eye provides a "window" on the cerebral circulation and the opportunity to observe effects on the cerebral microvasculature, because the retina develops as an outgrowth of the embryonic brain and the retinal artery is a branch of the cerebral artery. Abnormal fluorescein angiograms suggestive of retinal damage have been reported in patients having coronary artery bypass grafting (CABG) with cardiopulmonary bypass CABG-CPB, 2,3 and "particles" in the blood (gas or microemboli) in the cerebral circulation detected with transcranial Doppler ultrasound have been observed more often during CABG-CPB than off-pump coronary artery bypass (OPCAB) surgery.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Retinal and Cerebral Microembolization During Coronary Artery Bypass Surgery

et al. 2005

View full text Add to dashboard Cite

Background-We sought to compare the effects on ophthalmic function of coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and off-pump (OPCAB) grafting and to investigate whether retinal microvascular damage is associated with markers of cerebral injury. Methods and Results-Retinal microvascular damage was assessed by fluorescein angiography and color fundus photography. Ophthalmic function was tested by the logarithm of the minimum angle of resolution visual acuity (VA), and cerebral injury, by transcranial Doppler ultrasound-detected emboli and S100 protein values. Twenty patients were randomized. Fluorescein angiography and postoperative VA could not be obtained for 1 CABG-CPB patient. Retinal microvascular damage was detected in 5 of 9 CABG-CPB but in none of 10 OPCAB patients (risk difference, 55%; 95% confidence interval [CI], 23% to 88%; Pϭ0.01). Color fundus photography detected microvascular damage in 1 CABG-CPB patient but in no OPCAB patients; this lesion was associated with a field defect, which remained after 3 months of follow-up. There was no difference in postoperative VA. Doppler high-intensity transient signals (HITS) were 20.3 times more frequent in the CABG-CPB than in the OPCAB group (95% CI, 9.1 to 45; PϽ0.0001). Protein S100 levels were higher in the CABG-CPB than in the OPCAB group 1 hour after surgery (PϽ0.001). HITS were 14.7 times more frequent (95% CI, 3.5 to 62; Pϭ0.001) and S100 level 2.1 times higher (95% CI, 1.3 to 3.5; Pϭ0.005) when retinal microvascular damage was present. Conclusions-The

show abstract

Section: Sample Size and Statistical Analysismentioning

confidence: 99%

mentioning

confidence: 99%

Retinal and Cerebral Microembolization During Coronary Artery Bypass Surgery

et al. 2005

View full text Add to dashboard Cite

show abstract

“…1,2 A number of studies suggest that the PhNR in the photopic ERG originates primarily from activity of RGCs and their axons. [1][2][3][4][5][6][7][8][9] In clinical studies using full-field ERGs, the PhNR amplitude was reduced in various diseases that involves RGC damageFfor example, glaucoma, [3][4][5] retinal vascular disease, 6,7 and optic nerve diseases. [8][9][10] Several researchers measured PhNR by using focal macular ERG in humans and monkeys.…”

Section: Introductionmentioning

confidence: 99%

Focal macular photopic negative response in patients with optic neuritis

Nakamura

Miyamoto

Yokota

et al. 2011

Eye

View full text Add to dashboard Cite

Purpose To investigate, by focal macular electroretinography (ERG), the change of photopic negative response (PhNR) in the recovery of visual function in patients with optic neuritis. Methods Focal macular ERG was recorded from nine patients with acute optic neuritis (38.6±10.2 years). The photostimulator device projected 151 visual angle spotlight onto the macula. Focal macular ERG recording was performed at the onset and at 1 month and 6 months after the onset of optic neuritis. The results were compared between each recording for seven of the patients. Results All patients decreased in the vision below 20/100 and had central scotoma. Vision improved more than 20/20 within 1 month and full-visual field recovered within 6 months after the onset in all patients. The amplitude of the a-wave, b-wave, and PhNR of focal macular ERG at the onset was significantly attenuated in eyes with optic neuritis (66.8±15.5, 65.8±17.7, and 65.2±14.4% of normal control, respectively). The amplitude of the a-wave and b-wave increased gradually after steroid pulse therapy. The increase in a-wave amplitude was significant at 6 months (P ¼ 0.046), whereas the PhNR amplitude did not show any significant change over 6 months after the onset of optic neuritis. Conclusions Our results suggest that inflammation at the onset of optic neuritis leads to functional deficits that extend to at least the inner nuclear layers of the retina, and that all but the ganglion cell layers of retina recover.

show abstract

“…Two limitations of Ganzfeld ERG in TRAO are: (1) branch pattern TRAO may not be detected; and (2) b-wave attenuation on ERG reverses fully after 30 min in experimental models of transient retinal ischaemia. 4 ERG evidence of widespread ischaemia may vanish before testing takes place.…”

Section: Sir Transient Retinal Artery Occlusion: the Potential Utilimentioning

confidence: 99%

“…Retinal vasospasm has been observed directly during a migrainous episode, and has also been implicated as a possible cause of branch retinal arteriolar occlusion in the presence of migraine. 3,4 Furthermore, studies have shown patients with migraine to have reduced RNFL thickness, suggesting that, although vasospasm is in itself a transient occurrence, the chronic natural history of migraine may lead to permanent structural changes. 5 This small case series highlights an association between migraine and CWS, and emphasises the importance of taking a full medical history when assessing patients with sudden onset of visual field defect secondary to CWS.…”

Section: Commentmentioning

confidence: 99%