Predominant polarity as a neurobiological specifier in bipolar disorder: Evidence from a multimodal neuroimaging study

Argyropoulos, G; Christidi, Foteini; Karavasilis, Efstratios; Bede, Peter; Antoniou, Anastasia; Velonakis, Georgios; Seimenis, Ioannis; Kelekis, Nikolaos; Smyrnis, Nikolaos; Papakonstantinou, Olympia; Efstathopoulos, Efstathios; Ferentinos, Panagiotis

doi:10.1016/j.pnpbp.2023.110718

Cited by 6 publications

(11 citation statements)

References 72 publications

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“…Studies were published between 2009 40 , 50 and 2023. 31 All studies, with the exception of one reported in Spanish, 43 were written in English. The sample sizes varied between 42 31 and 788.…”

Section: Resultsmentioning

confidence: 99%

“… 31 All studies, with the exception of one reported in Spanish, 43 were written in English. The sample sizes varied between 42 31 and 788. 50 The majority of studies ( k = 16) were conducted in Europe, i.e.…”

Section: Resultsmentioning

confidence: 99%

“…six were from Italy, 30 , 38 – 41 , 45 three from Spain, 15 , 46 , 49 two from France 32 , 42 and Germany, 51 , 52 and one each from Belgium, 18 Finland 17 and Greece. 31 Five studies were conducted in Asia: four in India 16 , 36 , 44 , 47 and one in Singapore; 37 and five studies in South America, i.e. three were from Brazil 33 , 34 , 48 and two from Colombia.…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies have reported, for example, that individuals with predominant polarity – especially those with mPP – may show differences in cortical thickness in several areas of the central nervous system. 31 , 35 Further evidence highlighted that biomarkers of bipolar disorder may be more influenced by its specific clinical features, e.g. depression and mania, than by the disease itself.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis

Bartoli,

Bassetti,

Gazzola

et al. 2024

BJPsych open

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Background Identification of the predominant polarity, i.e. hypomanic/manic (mPP) or depressive predominant polarity (dPP), might help clinicians to improve personalised management of bipolar disorder. Aims We performed a systematic review and meta-analysis to estimate prevalence and correlates of mPP and dPP in bipolar disorder. Method The protocol was registered in the Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/8S2HU). We searched main electronic databases up to December 2023 and performed random-effects meta-analyses of weighted prevalence of mPP and dPP. Odds ratios and weighted mean differences (WMDs) were used for relevant correlates. Results We included 28 studies, providing information on rates and/or correlates of mPP and dPP. We estimated similar rates of mPP (weighted prevalence = 30.0%, 95% CI: 23.1 to 37.4%) and dPP (weighted prevalence = 28.5%, 95% CI: 23.7 to 33.7%) in bipolar disorder. Younger age (WMD = −3.19, 95% CI: −5.30 to −1.08 years), male gender (odds ratio = 1.39, 95% CI: 1.10 to 1.76), bipolar-I disorder (odds ratio = 4.82, 95% CI: 2.27 to 10.24), psychotic features (odds ratio = 1.56, 95% CI: 1.01 to 2.41), earlier onset (WMD = −1.57, 95% CI: −2.88 to −0.26 years) and manic onset (odds ratio = 13.54, 95% CI: 5.83 to 31.46) were associated with mPP (P < 0.05). Depressive onset (odds ratio = 12.09, 95% CI: 6.38 to 22.90), number of mood episodes (WMD = 0.99, 95% CI: 0.28 to 1.70 episodes), history of suicide attempts (odds ratio = 2.09, 95% CI: 1.49 to 2.93) and being in a relationship (odds ratio = 1.98, 95% CI: 1.22 to 3.22) were associated with dPP (P < 0.05). No differences were estimated for other variables. Conclusions Despite some limitations, our findings support the hypothesis that predominant polarity might be a useful specifier of bipolar disorder. Evidence quality was mixed, considering effects magnitude, consistency, precision and publication bias. Different predominant polarities may identify subgroups of patients with specific clinical characteristics.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis

Bartoli,

Bassetti,

Gazzola

et al. 2024

BJPsych open

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“…The reason why this would support our understanding is because longitudinal studies, where people are followed during their susceptibility to a condition, can often enable us to understand the temporal changes in neurobiological markers [ 4 ]. Through the combination of multimodal strategies, including genetic analysis alongside modern neuroimaging techniques, a further understanding of the interaction between genetics and a neurological unit can be obtained [ 45 ].…”

Section: Reviewmentioning

confidence: 99%

Neuroimaging and Brain-Based Markers Identifying Neurobiological Markers Associated With Criminal Behaviour, Personality Disorders, and Mental Health: A Narrative Review

Al-Juhani,

Alzahrani,

Abdullah A

et al. 2024

Cureus

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We begin the review by pointing to the common stigma associated with mental health issues, which often derives from a lack of understanding or incomplete knowledge. Neurobiological research provides us with a new lens to help challenge and dispel common assumptions and misunderstandings and gives an understanding of sexual behaviours that influence society. As such, it generates substantial evidence for the structural and functional asymmetry of the brains of individuals with mental disorders. However, this type of representation poses many challenges to traditional thinking and constantly provokes change in perspective and empathy towards those individuals. In the review, we go deeper into the effects of neurobiological findings on understanding criminal behaviours and personality disorders, looking further beyond behavioural health. These problems, which were once mainly discussed as moral ones or viewed from the perspective of character flaws, are analysed today through neurological considerations pointing to their complexity. When the root of bipolar disorder is revealed to be neurological, society will react with more information and understanding, hence reducing the stigmatisation and discrimination meted out to people with these problems. At a macro level, findings from neurobiology affect society in ways that go beyond individuals; social attitudes, laws, and policies about the services rendered are influenced. Operating as a catalyst within the community, neurobiological research helps to initiate social change through the creation of an informed, understanding public forum. Thus, it creates broader value for those dealing with behavioural and mental health challenges. The first and most important question of this narrative review is focused on identifying identifiable neurobiological markers that are closely related to criminal conduct, personality disorders, and mental health disorders. Through this review, we aim to present detailed insights into the neurological foundations that anchor these phenomena via a narrative analysis of contemporary literature. The potential implications are finding problems early to apply specific treatment and learning an advanced strategy for social attitudes. This will promote a more humanistic approach based on adequate information on the behavioural and mental health issues involved.

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Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode

Gao,

Chen,

Cui

et al. 2024

BMC Psychiatry

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Predominant polarity as a neurobiological specifier in bipolar disorder: Evidence from a multimodal neuroimaging study

Cited by 6 publications

References 72 publications

Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis

Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis

Neuroimaging and Brain-Based Markers Identifying Neurobiological Markers Associated With Criminal Behaviour, Personality Disorders, and Mental Health: A Narrative Review

Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode

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