Predominant polarity in bipolar disorders: Further evidence for the role of affective temperaments

Predominant polarity in bipolar I and II disorders: a five-year follow-up study

“…This is problematic since for clinical purposes such evaluations should be done as early as possible to prevent chronicity. In accord with many previous studies Daban et al, 2006;Rosa et al, 2008;Forty et al, 2009;Mazzarini et al, 2009;Baldessarini and Undurraga et al2012;Popovic et al, 2014;Azorin et al, 2015;Janiri et al, 2017), we found an association between the predominant polarity and the polarity of the first illness episode, which might be a useful predictor early in the course of bipolar illness. The optimal time-point for evaluation of predominant polarity remains to be elucidated by future studies.…”

“…A history or higher number of suicide attempts Gonzalez-Pinto et al, 2010;Baldessarini and Undurraga et al2012;Popovic et al, 2014) has repeatedly been linked to DP, and moreover, when mixed states were combined with the depressive category, the association with suicide attempts almost doubled (Baldessarini and Undurraga et al2012). In contrast, Azorin et al (Azorin et al, 2015) found the MP group to have more suicide attempts and explained this by higher levels of cyclothymic and hyperthymic temperaments in MP. A 7-year longitudinal cohort study also found higher number of SAs in the MP group (Belizario et al, 2018).…”

“…Some studies have applied a less strict definition of simply having more lifetime episodes of either manic or depressive polarity Forty et al, 2009;Gonzalez-Pinto et al, 2010), whereas most studies have used the definition of Colom et al (Colom et al, 2006;Rosa et al, 2008;Garcia-Lopez et al, 2009;Mazzarini et al, 2009;Vieta et al, 2009;Murru et al, 2011;Nivoli et al, 2011;Popovic et al, 2014;Belizario et al, 2018;Vidal-Rubio et al, 2018), and only a few both (Baldessarini and Salvatore et al2012;Azorin et al, 2015). When defining the polarity, mixed episodes are excluded in most studies.…”

“…Some studies have reported the occurrence of anxiety disorders (Azorin et al, 2015) and DSM-IV axis II comorbidity (Baldessarini and Undurraga et al2012) to be more frequent in the DP group, while others have not found association with (current) comorbid mental disorders and polarity dominance (Koyuncu et al, 2010;Murru et al, 2011;Popovic et al, 2014). However, as the current illness phase is known to strongly covary with the prevalence of psychiatric comorbidity both cross-sectionally and longitudinally (Mantere et al, 2010;Pavlova et al, 2015), the association of comorbid internalizing disorders with DP and externalizing disorders with MP is plausible.…”

Is Mania the Hypertension of the Mood? Discussion of A Hypothesis

“…One could argue that alcoholism is a very common condition to be comorbid with several disorders. However, it should be noted that the elevated alcohol-use disorder comorbidity is rather characteristic of bipolar than of unipolar depression [7, 144, 145], and alcohol use disorder is more common among bipolar patients with predominant (hypo)manic polarity than those with predominant depressive polarity [146]. …”