Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus

Zhang, Qian; Xiang, Liping; Zaman, Muhammad Haidar; Dong, Wenhui; He, Guodan; Deng, Guo-Min

doi:10.3389/fimmu.2019.03020

Cited by 30 publications

(36 citation statements)

References 44 publications

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“…Body weight did not vary, however NZBW mice exposed to PM2.5 presented higher weight of organs compared to NZBW-FA group. Increase in weight of lymphoid organs such as thymus and spleen can be associated with systemic condition of increased disease activity, characterized by hyperplasia of lymphoid follicles present in these organs [ 68 , 69 ]. Increase in weight of liver is frequently associated with splenomegaly in SLE patients, however the mechanisms involved are not elucidated [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

et al. 2021

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Background Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 μg/m3 of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Results Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. Conclusions This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

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Section: Discussionmentioning

confidence: 99%

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

et al. 2021

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“…Studies have unveiled the promoted levels of TNF-α and C-C Motif Chemokine Ligand 5 (CCL5) mRNA provoked by TLR4 and TLR7 in spleen macrophages of lupus-susceptible mice ( Murphy et al., 2017 ). The spleen of mice in the model group also showed pathological conditions, such as splenomegaly ( Zhang et al., 2019 ). Additionally, the expression levels of IRAK1-NF-κB in the kidneys of the model group were higher than those in the spleen, and the effects of JP intervention were also significantly reduced in the kidneys ( Figures 7E, F , 9 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

Jieduquyuziyin Prescription Suppresses Inflammatory Activity of MRL/lpr Mice and Their Bone Marrow-Derived Macrophages via Inhibiting Expression of IRAK1-NF-κB Signaling Pathway

Fan

Hou

et al. 2020

Front. Pharmacol.

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Jieduquyuziyin prescription (JP) has been used to treat systemic lupus erythematosus (SLE). Although the effectiveness of JP in the treatment of SLE has been clinically proven, the underlying mechanisms have yet to be completely understood. We observed the therapeutic actions of JP in MRL/lpr mice and their bone marrow-derived macrophages (BMDMs) and the potential mechanism of their inhibition of inflammatory activity. To estimate the effect of JP on suppressing inflammatory activity, BMDMs of MRL/lpr and MRL/MP mice were treated with JP-treated serum, and MRL/lpr mice were treated by JP for 8 weeks. Among them, JP and its treated serum were subjected to quality control, and BMDMs were separated and identified. The results showed that in the JP group of BMDMs stimulated by Lipopolysaccharide (LPS) in MRL/lpr mice, the secretion of interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) reduced, and the expressions of Interleukin-1 receptor-associated kinase 1 (IRAK1) and its downstream nuclear factor kB (NF-kB) pathway decreased. Meanwhile, the alleviation of renal pathological damage, the decrease of urinary protein and serum anti-dsDNA contents, the inhibition of TNF-a level, and then the suppression of the IRAK1-NF-kB inflammatory signaling in the spleen and kidney, confirmed that the therapeutic effect of JP. These results demonstrated that JP could inhibit the inflammatory activity of MRL/lpr mice and their BMDMs by suppressing the activation of IRAK1-NF-kB signaling and was supposed to be a good choice for the treatment of SLE.

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“…Body weight did not vary, however NZBW mice exposed to PM2.5 presented higher weight of organs compared to NZBW-FA group. Increase in weight of lymphoid organs such as thymus and spleen can be associated with systemic condition of increased disease activity, characterized by hyperplasia of lymphoid follicles present in these organs [66,67]. Increase in weight of liver is frequently associated with splenomegaly in SLE patients, however the mechanisms involved are not elucidated [68].…”

Section: Discussionmentioning

confidence: 99%

Chronic Exposure to PM2.5 Aggravates SLE Manifestations in Lupus-Prone Mice

Yariwake

Quiroz²,

Santos

et al. 2020

Preprint

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Background: Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600µg/m³ of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed.Results: Female NZBW mice exposed to CAP presented decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA.Conclusions: This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

show abstract

Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus

Cited by 30 publications

References 44 publications

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

Jieduquyuziyin Prescription Suppresses Inflammatory Activity of MRL/lpr Mice and Their Bone Marrow-Derived Macrophages via Inhibiting Expression of IRAK1-NF-κB Signaling Pathway

Chronic Exposure to PM2.5 Aggravates SLE Manifestations in Lupus-Prone Mice

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