Predominant type 1 CMV-Specific memory T-helper response in humans: evidence for gender differences in cytokine secretion

Villacres, Maria C.; Longmate, Jeffrey; Augé, Catherine; Diamond, Don J.

doi:10.1016/j.humimm.2004.02.021

Cited by 99 publications

(80 citation statements)

References 53 publications

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“…Besides a possible association with the IFN-␥ molecule (35), the immune mechanisms contributing to gender-dependent susceptibility to herpesvirus infection and disease have not been reported. A recent study by Diamond and coworkers demonstrated a higher frequency of memory T cells specific to human cytomegalovirus-another virus of the herpesvirus family-that produce higher levels of Th1 cytokines in women than in men (74). On the contrary, Klein and coworkers showed that women maintain lower levels of varicella-zoster virus-specific memory T cells compared to men (37).…”

Section: Discussionmentioning

confidence: 99%

“…Activation of T cells with APCs derived from the opposite sex demonstrated that these cytokines were derived from the respective APC populations (78). Other studies have demonstrated that gender differences in T-cell responses are mediated, in part, by differences in sex hormoneimmune interactions (37,42,51,57,74,78). Kovats and coworkers were the first to demonstrate that sex hormones such as estrogen play a crucial role in regulating dendritic cell phenotypic and functional differentiation (42,51,57).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Zhang

Castelli

Zhu

et al. 2008

Clin Vaccine Immunol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Zhang

Castelli

Zhu

et al. 2008

Clin Vaccine Immunol

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“…For viral infections, females are thought to be more likely to develop T H 1 responses in mouse studies (Villacres et al 2004) and, thus, in infections where a T H 1 response is protective, such as vesicular stomatitis virus (Barna et al 1996) or herpes simplex virus (HSV) (Han et al 2001), female mice are more resistant to disease. Whereas in infections where T H 1 responses are more pathogenic, such as in lymphocytic choriomeningitis virus infection, female mice develop enhanced pathology (Muller et al 1995).…”

Section: Viral Infectionsmentioning

confidence: 99%

Gender Specific Differences in the Immune Response to Infection

McClelland

Smith

2011

Arch. Immunol. Ther. Exp.

159

134

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There are many instances where males and females differ in the susceptibility to infections. The reason for these differences in susceptibility is multifactorial. The primary cause is thought to be due to differences induced by sex hormones and their effects on gene expression as well as the immune system, but may also be due to innate physiological differences between males and females. This review summarizes gender specific differences seen in infections caused by bacteria, fungi, parasites and viruses. Ultimately, gender specific differences appear to be dependent on the microbe causing the infection, as not every infection with a specific microbial type results in increased susceptibility of one gender over the other. This suggests that there is an interaction between gender specific immune differences and the specific immune response to individual microbes.

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“…However, there was no correlation between cytokine release in individual patients and changes of serum sex hormone levels. Villacres et al [15] studied the reaction of CD4 + cells from donors of both sexes after viral infection. According to their results, women were characterized by higher and significant spontaneous release of IFN-g and cytomegalovirus-specific IL-2 secretion.…”

Section: Introductionmentioning

confidence: 99%

Influence of oxygen concentration on T cell proliferation and susceptibility to apoptosis in healthy men and women

Waskowska¹,

Lisowska

Daca³

et al. 2017

Folia Histochem Cytobiol.

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Introduction.Much of what we know about the functioning of human T lymphocytes is based on the experiments carried out at atmospheric oxygen (O 2 ) concentrations, which are significantly higher than those maintained in blood. Interestingly, the gender differences in the activity of T cells and their susceptibility to apoptosis under different O 2 conditions have not yet been described. The aim of the study was to compare two main markers of lymphocyte function: proliferation capacity and ability to produce cytokines as well as their susceptibility to apoptosis under two different O 2 concentrations, between men and women. Material and methods. 25 healthy volunteers, both males (13) and females (12) were recruited to the study (mean age 25.48 ± 5.51). By using cytometry proliferation parameters of human CD4 + CD28+ cells or CD8 + CD28 + cells in response to polyclonal stimulation of the TCR/CD3 complex at atmospheric (21%) and physiological (10%) O 2 concentrations using our modified dividing cell tracking technique (DCT) were analyzed as well as the percentages of apoptotic cells. We also determined the levels of IFN-g, IL-2, IL-10 and IL-17A using Cytometric Bead Array Flex system in cell culture supernatants. Results. CD4+ CD28 + and CD8 + CD28 + cells from the whole study group were characterized by shorter time required to enter the first (G1) phase of the first cell cycle at 21% compared to 10% O 2 . Both T cell populations performed significantly more divisions at 21% O 2 . The percentages of dividing cells were also significantly higher at atmospheric O 2 . Interestingly, data analysis by gender showed that male lymphocytes had similar proliferative parameters at both O 2 concentrations while female lymphocytes proliferate more efficiently at 21% oxygen. Compared to males, the female CD4 + cells showed increased susceptibility to apoptosis at both O 2 concentrations. No differences in the levels of cytokines regardless of gender and oxygen conditions were found. Conclusions. We showed that in vitro female T cells (both CD4 + and CD8 + cells) are more sensitive than male lymphocytes to low O 2 concentration as demonstrated by the decrease in their proliferation dynamics. The effect does not depend on increased apoptosis of female T cells under low O 2 because percentage of apoptotic cells was similar at both O

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Predominant type 1 CMV-Specific memory T-helper response in humans: evidence for gender differences in cytokine secretion

Cited by 99 publications

References 53 publications

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Gender Specific Differences in the Immune Response to Infection

Influence of oxygen concentration on T cell proliferation and susceptibility to apoptosis in healthy men and women

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