Predominantly Cystic Central Mucoepidermoid Carcinoma Developing from a Previously Diagnosed Dentigerous Cyst: Case Report and Review of the Literature

Abstract

Primary intraosseous mucoepidermoid carcinoma of the jawbones is an extremely rare malignant salivary gland tumour constituting 2-4.3% of all the reported mucoepidermoid carcinomas. We report a case of intraosseous mucoepidermoid carcinoma of the mandible in an 80-year old female patient developing from a previously diagnosed dentigerous cyst. An excisional biopsy was performed and the histopathological features confirmed low grade-cystic intraosseous mucoepidermoid carcinoma. The origin of central mucoepidermoid carcinoma could be suggested to be from the epithelial lining of previously diagnosed dentigerous cyst. Thus, emphasizing the need for careful examination of the entire excision specimen to rule out such neoplastic transformation of epithelial lining of odontogenic cyst and provide appropriate and effective treatment.

Common Matrix Metalloproteinases ( M MP - 8, -9, -25, and -26) Cannot Explain Dentigerous Cyst Expansion

“…The change of DC to malignant form is a rarity, however, several carcinoma subtypes such as epidermoid, mucoepidermoid and intraosseous carcinomas have been reported [1,2,19,20]. Of these subtypes the intraosseous carcinoma seems to be the most common one.…”

Central mucoepidermoid carcinoma radiographically mimicking an odontogenic tumor: A case report and literature review

“…[ 3 5 ] In this case, the provisional diagnosis was ameloblastoma, just as the most common diagnostic hypotheses are tumors and odontogenic cysts as observed in Table 1 . [ 12 13 14 15 16 17 18 19 20 21 22 23 ]…”

High-grade central mucoepidermoid carcinoma arising in an odontogenic cyst: a case report and review of the literature

“…Clinical symptoms of CMEC are usually strictly connected with tumor localization. The most common signs and symptoms are: asymmetry caused by intraosseous expansion [3,6,[8][9][10][11][12][15][16][17][18][19][20][21][22][23], pain [3,[8][9][10][11][18][19][20][21][22][23], higher tooth mobility [24], trismus [8,24], and bleeding [23]. The following are less frequently mentioned in the literature [11,22,24]: nasal congestion [17], headaches [17], tinnitus [10,25], loss of hearing [25], or diplopia [20], when it comes to the maxilla.…”