“…The learning rules used by PC networks (PCNs) require only local and Hebbian updates (Millidge, Tschantz, Seth & Buckley, 2020b) and a variety of neural microcircuits have been proposed that can implement the computations required by PC (Bastos et al, 2012;Keller & Mrsic-Flogel, 2018). Moreover, recent works have begun exploring the use of large-scale PCNs in machine learning tasks, to some success (Kinghorn, Millidge & Buckley, 2021;Lotter, Kreiman & Cox, 2016;Millidge, 2019;Ofner & Stober, 2021;Salvatori, Pinchetti et al, 2022;Salvatori et al, 2021). Unlike the other algorithms presented here, PC has a mathematical interpretation as in terms of variational Bayesian inference (Bogacz, 2017;Buckley, Kim, McGregor & Seth, 2017;Friston, 2003Friston, , 2005Millidge, Seth & Buckley, 2021), and the variables in the model can be mapped to explicit probabilistic elements of a generative model.…”