Preeclampsia 2012

Abstract

Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options.

Materno-fetal outcomes in pre eclampsia in a rural hospital of Antananarivo Madagascar

“…1 The prevalence of preeclampsia found in our study was 1.68%. The major problem found was the poor management of hypertensive states.…”

“…It is a humanpregnancy-specific disease defined as the occurrence of hypertension and significant proteinuria in a previously healthy woman on or after the 20 th week of gestation. 1 The systolic blood pressure (SBP) is greater than or equal to 140mmHg or the diastolic blood pressure (DBP) is greater than or equal to 90mmHg or higher, on two occasions at least 4hours apart in a previously normotensive patient; and a significant proteinuria is >0.3g/24H. 2 Pre-eclampsia is one of the leading causes of maternal and perinatal morbidity and mortality worldwide.…”

Family history of hypertension increases risk of preeclampsia in pregnant women: a case-control study

“…(23) The increased risk of preeclampsia suggests that acute maternal infection may play a role in the pathogenesis of preeclampsia. (39) Various hypotheses have been proposed to explain the mechanism by which maternal infection may be associated with preeclampsia. A key feature of preeclampsia is the greater systemic inflammatory response of women who develop the syndrome compared to women who have normal pregnancies (40) which suggest that inflammation may play an important role in the pathogenesis.…”

Retraction: Etiopathology of preeclampsia — Recent progress from the perspective of a poor/ischemic placenta

“…There is extensive evidence in the literature that the reduction of uteroplacental blood flow results in a combination of hypoxia, upregulation of placental HIF-1α, imbalance of angiogenic (vascular endothelial growth factor [VEGF], placental growth factor [PlGF]) and antiangiogenic (sFlt-1) factors, inflammation, deranged immunity, and increased endothelin-1 14) and AT1-AA 15) expression. Placental hypoperfusion appears to be both a cause and a consequence of abnormal placental development.…”