Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and beta-carotene in women with preeclampsia

Mikhail, Magdy S.; Anyaegbunam, Akolisa; Garfinkel, David; Palan, Prabhudas R.; Basu, Jayasri; Romney, Seymour L.

doi:10.1016/0002-9378(94)90462-6

Cited by 222 publications

(120 citation statements)

References 23 publications

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“…to normal pregnancy are seen (11) and the present values also agree with the same. High availability of unsaturated lipid could contribute to a predisposition to enhance lipid peroxidation.…”

Section: -200supporting

confidence: 91%

Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension

Rao

Sumita

Roshni

et al. 2005

Indian J Clin Biochem

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It has been suggested that antioxidant systems are impaired in pregnancy induced hypertc, nsion and hence patients are exposed to oxidative stress. In order to investigate the relationship between lipid peroxidation and certain antioxidant parameters in blood of pregnancy induced hypertension (PIH) cases, 25 normotensive and 23 PIH samples were studied. In the present study, thiobarbitudc acid reactive substances showed a tendency to increase, however the increase remained statistically insignificant. Plasma ascorblc acid level remained unaltered and Vitamin E showed a tendency to increase in the study group. The findings implicate oxidative stress in the disease and cite the biochemical rationale for clinical trials of antioxidants to prevent and treat pregnancy induced hypertension.

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Section: -200supporting

confidence: 91%

Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension

Rao

Sumita

Roshni

et al. 2005

Indian J Clin Biochem

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“…It remains, however, to be determined whether vitamin E levels are changed in women with a severe degree of pregnancy-induced hypertension, but not in women with mild pregnancy-induced hypertension. Our study also showed no difference in plasma levels of various other lipid-soluble antioxidants during the third trimester between women with or without pregnancy-induced hypertension, which has also been reported for b-carotene (Mikhail et al, 1994). b g-Tocopherol, a-tocopherol, lutein, total tocopherol, and total carotenoid levels decreased from the third trimester to postpartum in the pregnancy-induced hypertension group, as compared with the changes in the control group.…”

Section: Control Group (N 23)supporting

confidence: 82%

“…For example, vitamin C has a sparing effect on vitamin E by regenerating the oxidized form (Niki, 1987). Although Mikhail et al (1994) found decreased plasma levels of vitamin C during the third trimester in women with pregnancy-induced hypertension, Uotila et al (1994) reported similar levels just before delivery in women with and without pregnancy-induced hypertension. In women with pregnancy-induced hypertension, Uotila et al (1994) also found increased plasma levels of uric acid and unidenti®ed antioxidants, both contributing to higher TRAP values.…”

Section: Control Group (N 23)mentioning

confidence: 99%

“…After delivery, plasma vitamin E levels were found to be similar in women with and without pregnancy-induced hypertension (Uotila et al, 1993b), as were plasma levels of the newborns in both groups (Uotila et al, 1993b;von Mandach et al, 1993). Reports on other lipid-soluble antioxidants in pregnancies complicated with pregnancyinduced hypertension are scarce and also inconclusive (Uotila et al, 1993b;Mikhail et al, 1994). These inconsistent results indicate that more antioxidants may have to be included in the evaluation of the antioxidant status in women with pregnancy-induced hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy-induced hypertension: maternal and neonatal plasma lipid-soluble antioxidant levels and its relationship with fatty acid unsaturation

et al. 1998

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Objective: Our purpose was to investigate whether plasma lipid-soluble antioxidant levels during the third trimester of pregnancy and immediately after birth are altered in women with pregnancy-induced hypertension. Design: Nested case-control study of women with pregnancy-induced hypertension. Subjects: A group of 23 women with (mild) pregnancy-induced hypertension and their neonates, were compared with 23 matched controls with uncomplicated pregnancies. Methods: Concentrations of vitamin E isomers, several carotenoids, and retinol were determined by HPLC in venous plasma which had been stored for 2 ± 5 y. Antioxidant levels were adjusted for the degree of fatty acid unsaturation in plasma phospholipids as analysed 2 ± 5 y before. Results: In the third trimester of pregnancy, lipid-soluble antioxidant levels were similar in women with pregnancy-induced hypertension and controls. From the third trimester to postpartum, mean ( AEs.e.m.) b gtocopherol levels decreased by 0.38 AE0.17 mmolal or 5% (P 0.038) in the control group. In the pregnancyinduced hypertension group, however, plasma levels of most antioxidants decreased from the third trimester to postpartum, but only the decreases in plasma levels of b g-tocopherol of 1.08 AE0.27 mmolal or 26% (P 0.042), of a-tocopherol of 2.51 AE1.58 mmolal or 6% (P 0.024), and of lutein of 0.13 AE0.04 mmolal or 15% (P 0.013) reached statistical signi®cance as compared with the changes in the control group. At the same time, the polyunsaturated fatty acid unsaturation index of plasma phospholipids (UI) decreased in the pregnancyinduced hypertension group as well. Consequently, antioxidant levels, adjusted for UI, changed similarly in both groups. Umbilical vein plasma antioxidant levels were also similar after complicated and uncomplicated pregnancies. Conclusion: Plasma lipid-soluble antioxidant levels in mother and child are affected by mild pregnancy-induced hypertension, but this effect disappears after adjustment for fatty acid unsaturation.

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“…In recent years, free radicals have emerged as likely promoters of maternal endothelial dysfunction. In pre-eclampsia, a rise in plasma markers of lipid peroxidation, including malondialdehyde (Hubel et al, 1996) and 8-epiprostaglandin-F2a (Barden et al, 1996), and a reduction in water-and lipid-soluble antioxidants in plasma (Mikhail et al, 1994) and placenta (Wang & Walsh, 1996) strongly suggest a state of oxidative stress. Reactive oxygen species (ROS), particularly superoxide anions, are a potential source of excessive oxidation.…”

Section: Introductionmentioning

confidence: 99%

Excessive stimulation of poly(ADP‐ribosyl)ation contributes to endothelial dysfunction in pre‐eclampsia

Crocker

Kenny

Thornton

et al. 2005

British J Pharmacology

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1 Pre-eclampsia is a serious pregnancy disorder associated with widespread activation of the maternal vascular endothelium. Recent evidence implicates a role for oxidative stress in the aetiology of this condition. 2 Reactive oxygen species, particularly superoxide anions, invokes endothelial cell activation through many pathways. Oxidant-induced cell injury triggers the activation of nuclear enzyme poly(ADP-ribose) polymerase (PARP) leading to endothelial dysfunction in various pathophysiological conditions (reperfusion, shock, diabetes). 3 We have studied whether the loss of endothelial function in pre-eclampsia is dependent on PARP activity. Endothelium-dependent responses of myometrial arteries were tested following exposure to either plasma from women with pre-eclampsia or normal pregnant women in the presence and absence of a novel potent inhibitor of PARP, PJ34. Additional effects of plasma and PJ34 inhibition were identified in microvascular endothelial cell cultures. 4 In myometrial arteries, PARP inhibition blocked the attenuation of endothelium-dependent responses following exposure to plasma from women with pre-eclampsia. In endothelial cell cultures, plasma from pre-eclamptics induced measurable oxidative stress and a concomitant increase in PARP activity and reduction in cellular ATP. Again, these biochemical changes were reversed by PJ34. 5 These results suggest that PARP activity plays a pathogenic role in the development of endothelial dysfunction in pre-eclampsia and promotes PARP inhibition as a potential therapy in this condition.

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Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, α-tocopherol, and beta-carotene in women with preeclampsia

Cited by 222 publications

References 23 publications

Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension

Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension

Pregnancy-induced hypertension: maternal and neonatal plasma lipid-soluble antioxidant levels and its relationship with fatty acid unsaturation

Excessive stimulation of poly(ADP‐ribosyl)ation contributes to endothelial dysfunction in pre‐eclampsia

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