Preeclampsia and the Antiphospholipid Syndrome

Mayer-Pickel, Karoline; Nanda, Manurishi; Gajic, Maja; Cervar-Zivkovic, Mila

doi:10.3390/biomedicines11082298

Cited by 6 publications

(2 citation statements)

References 196 publications

(264 reference statements)

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“…If there is an increased risk of uteroplacental dysfunction with the risk of IUGR, low-dose acetylsalicylic acid (ASA; 100–150 mg/die) should be started prophylactically at < 16 weeks gestation [ 102 ]. Patients with antiphospholipid syndrome (APS) should be advised before conception and treated with low-dose ASA and low-molecular-weight heparin from early pregnancy onwards [ 103 ]. Nutritional interventions supplementing the nitric oxide (NO) precursor levo-arginine had beneficial effects on fetoplacental circulation, birth weight, and neonatal outcomes [ 104 ].…”

Section: Strategies To Prevent or Mitigate Iugrmentioning

confidence: 99%

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Nüsken,

Appel,

Saschin

et al. 2024

Cells

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Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is below the tenth percentile. IUGR can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnion, lack of growth in the interval, estimated weight below the third percentile) and can also be present in fetuses and neonates with weights above the tenth percentile. There is a need to differentiate between IUGR and SGA whenever possible, as IUGR in particular is associated with greater perinatal morbidity, prematurity and mortality, as well as an increased risk for diseases in later life. Recognizing fetuses and newborns being “at risk” in order to monitor them accordingly and deliver them in good time, as well as to provide adequate follow up care to ameliorate adverse sequelae is still challenging. This review article discusses approaches to differentiate IUGR from SGA and further increase diagnostic accuracy. Since adverse prenatal influences increase but individually optimized further child development decreases the risk of later diseases, we also discuss the need for interdisciplinary follow-up strategies during childhood. Moreover, we present current concepts of pathophysiology, with a focus on oxidative stress and consecutive inflammatory and metabolic changes as key molecular mechanisms of adverse sequelae, and look at future scientific opportunities and challenges. Most importantly, awareness needs to be raised that pre- and postnatal care of IUGR neonates should be regarded as a continuum.

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Section: Strategies To Prevent or Mitigate Iugrmentioning

confidence: 99%

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Nüsken,

Appel,

Saschin

et al. 2024

Cells

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“…В большинстве случаев она возникает после 34 недель гестации. Раннее развитие (от 20 до 34 недель) и тяжёлое течение нефропатии беременных свойственно пациенткам с антифосфолипидным синдромом [35].…”

Section: факторы риска и течение преэклампсииunclassified

Pregnancy, Kidneys, Hypertension

Posokhov

2024

A.I. Burnasyan Federal Medical Biophysical Center Clinical Bull

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Preeclampsia, often presenting as new-onset hypertension and proteinuria in the third trimester of pregnancy, can rapidly progress to serious complications and therefore presents a unique challenge, simultaneously affecting both mother and fetus, sometimes putting their well-being at odds with each other. This condition may require fairly high competencies not only from obstetricians-gynecologists, but also from doctors of other specialties, including internists and general practitioners, cardiologists, nephrologists, laboratory and functional diagnostics doctors. This literature review was prepared with the aim of summarizing and briefly presenting modern ideas about theoretical and practical issues about the relationship between pregnancy, kidney function, and blood pressure that are important for these specialists.

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Proteomic Analysis Reveals Differential Protein Expression in Placental Tissues of Early-Onset Preeclampsia Patients

Zhou,

Hu,

Zhang

et al. 2024

J. Proteome Res.

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Preeclampsia, a significant cause of maternal and perinatal morbidity and mortality, remains poorly understood, in terms of its pathogenesis. This study aims to uncover novel and effective biomarkers for preeclampsia by conducting a comparative analysis of differential proteins in placentas from early onset preeclampsia (EOPE) and normal pregnancies. Utilizing tandem mass tag (TMT)-based quantitative proteomics, we identified differentially expressed proteins in placental tissues from 15 EOPE patients and 15 normal pregnant women. These proteins were subsequently validated by using parallel reaction monitoring (PRM). Our analysis revealed a total of 59 differentially expressed proteins, with 25 up-regulated and 34 down-regulated proteins in EOPE placental tissues compared to those from normal pregnancies. Validation through PRM confirmed the differential expression of 6 proteins. Our findings suggest these 6 proteins could play crucial roles in the pathogenesis of EOPE, highlighting the potential involvement of the estrogen signaling pathway and dilated cardiomyopathy (DCM) pathway in the development of preeclampsia. The data were deposited with the ProteomeXchange Consortium via the iProX partner repository with the identifier PXD055025.

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Preeclampsia and the Antiphospholipid Syndrome

Cited by 6 publications

References 196 publications

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Pregnancy, Kidneys, Hypertension

Proteomic Analysis Reveals Differential Protein Expression in Placental Tissues of Early-Onset Preeclampsia Patients

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