Preeclampsia and the longitudinal risk of hospitalization for depression at 28 years

Auger, Nathalie; Low, Nancy; Paradis, Gilles; Ayoub, Aimina; Fraser, William D.

doi:10.1007/s00127-020-01920-x

Cited by 12 publications

(11 citation statements)

References 30 publications

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“…In particular, some studies have showed an association between postpartum psychiatric episodes and pre-eclampsia in women with MB ( 53 , 54 ), while other studies did not found this association ( 55 ). More recently, Auger et al ( 56 ) found that preeclampsia is associated with a modest increase in the risk of hospitalization for depression up to three decades after pregnancy, suggesting a shared biologic pathway between depression and preeclampsia, which includes inflammation and oxidative stress ( 57 , 58 ).…”

Section: Discussionmentioning

confidence: 99%

The Transition From Maternity Blues to Full-Blown Perinatal Depression: Results From a Longitudinal Study

et al. 2021

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Background: The aims of the present study are to: (1) assess the frequency of maternity blues (MB); (2) identify the clinical and social characteristics more frequently associated with the onset of depressive symptoms after delivery; and (3) verify the hypothesis that the presence of maternity blues is a risk factor for the onset of a full-blown depressive episode in the 12 months after delivery.Methods: This is a longitudinal observational study. All pregnant women who gave birth at the inpatient unit of Gynecology and Obstetrics of the University of Campania “Luigi Vanvitelli” from December 2019 to February 2021 have been invited to participate in the study. Upon acceptance, women were asked to complete the Italian version of the Edinburgh Postnatal Depression Scale along with an ad-hoc questionnaire on the women's sociodemographic, gynecological and peripartum characteristics as well as their psychiatric history. Women have been reassessed after one, 3, 6 and 12 months.Results: A total of 359 women were recruited within 3 days from delivery, with a mean EPDS total score of 5.51 (±4.20). Eighty-three women (23.1%) reported the presence of maternity blues. Mean EPDS total scores were 12.8 (±0.2) in the MB group vs. 4.26 (±0.2) in the group without MB (p <0.0001). MB predictors were the presence of an anxiety disorder with an onset 6 months prior to pregnancy, of preeclampsia, of increased fetal health rate, of conflicts with relatives other than partner and having a partner with an anxiety disorder. At multivariate analyses the presence of MB increased 7-time the risk to have a higher EPDS score at follow-up assessments (OR: 7.79; CI: 6.88–8.70, p <0.000). This risk is almost four times higher 1 months after the delivery (OR: 4.66; CI: 2.54–6.75, p < 0.000), almost three times higher after 3 months (OR: 2.98; CI: 0.50–5.46, p < 0.01) and almost six times higher after 12 months (OR: 5.88; CI: 3.20–8.54, p < 0.000).Conclusions: Although MB was a self-limiting condition in the majority of cases, depressive symptoms arose quite often immediately after the childbirth. Professionals should be trained to monitor symptoms of MB and its transition toward a depressive episode.

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Section: Discussionmentioning

confidence: 99%

The Transition From Maternity Blues to Full-Blown Perinatal Depression: Results From a Longitudinal Study

et al. 2021

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“… 26–32 Auger et al observed that women with PE had a higher incidence of hospitalization for depression 28 years after indexed delivery and that late-onset PE was more consistently associated with hospitalization for depression within 1–4 years after pregnancy. 30 Similarly, Bergink et al reported an increased incidence risk ratio of 2.85 (95% CI, 1.84–4.42) for unipolar depression within 0–3 months postpartum in women who developed PE. 31 …”

Section: Resultsmentioning

confidence: 92%

“…As given in Table 5 , all three articles, Auger et al, Mommersteeg et al, and Chen et al, reported that positive associations between PE and postpartum depression remained significant after adjustment for prepregnancy BMI. 26 , 30 , 35 …”

Section: Resultsmentioning

confidence: 99%

Highlighting the Mechanistic Relationship Between Perinatal Depression and Preeclampsia: A Scoping Review

Yuan

Bedell

Vrijer

et al. 2022

Women's Health Reports

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Background: Although there is scientific literature supporting an association between depression and preeclampsia (PE), little is known about the underlying mechanistic pathways that may explain these observed associations. Thus, this study aimed to outline the relationship between depression and PE, and to highlight the underlying cardiovascular and metabolic risk factors that are common to both. Methods: A scoping review of the literature was conducted in Medline, Scopus, and Web of Science. Results: From 706 articles initially identified, 23 articles met the inclusion criteria and were included in this review. Although some studies reported a positive association between PE and postpartum depressive symptoms, challenges comparing different methodologies, measurement instruments and when measurements were administered, and patient populations do not permit a decisive conclusion. In addition, very few studies addressed potential underlying mechanisms that may be contributing to observed associations; thus, a secondary search was conducted to identify cardiovascular and metabolic risk factors that are common to both depression and PE. Conclusion: The cardiovascular and metabolic risk factors ( i.e., increased inflammation and oxidative stress and decreased vascular and endothelial function) common to both depression and PE suggest that these factors may contribute as underlying mechanisms in both conditions. These similarities underscore the importance to better understand these mechanisms so preventative and therapeutic strategies could be developed to improve maternal health.

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“…Keywords: dose; aspirin; low molecular weight heparin; preeclampsia; treatment; meta-analysis Background Preeclampsia (PE), as a kind of hypertension during pregnancy, is one of the important factors associated with maternal and perinatal death [1]. Studies [2,3] have shown that among the factors leading to maternal death, PE ranks the third, second only to bleeding and thrombosis. It's been reported [4,5] that more than 60,000 pregnant women die of PE worldwide every year.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of low-dose aspirin combined with low-molecular-weight heparin in treatment of preeclampsia: a meta-analysis and systematic review

Zhang

et al. 2021

Arch Med Sci

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IntroductionThe role of low dose aspirin combined with low-molecular-weight heparin(LMWH) in the treatment of preeclampsia(PE) remains unclear. We aimed to assess the efficacy and safety of low dose aspirin combined with LMWH in PE treatment, to provide evidence for the clinical PE management.Material and methodsWe searched PubMed, et al databases for randomized controlled trials(RCTs) on the effects and safety of low dose aspirin and LMWH in the treatment of PE up to Jan 31, 2021. Two researchers strictly followed the inclusion and exclusion criteria to independently conduct the literature screening, data extraction and quality evaluation. We used RevMan 5.3 statistical software for synthesized analysis.ResultsA total of 8 RCTs involving 861 patients were included. The synthesized outcome indicated that the differences in systolic blood pressure(MD=- 10.61, 95%CI-13.19 ~ -8.02), diastolic blood pressure(MD=- 9.24, 95%CI-14.49~ -4.00), 24-hour urinary protein (MD=- 2.24, 95%CI-3.97~ -0.50), PT(MD=1.42, 95%CI0.53~ -2.32), APTT (MD=2.91, 95%CI2.06~ 3.75), FIB (MD=-1.24, 95%CI-1.32~-1.15), adverse perinatal outcomes (MD=0.41, 95%CI0.20~0.85)between the two groups were statistically significant(all p<0.05), the difference in the adverse reactions of pregnant women(MD=0.44, 95%CI0.18~1.10) between the two groups was not statistically significant(P=0.08). No publication bias was detected in all the synthesized outcomes (all P>0.05).ConclusionsLow-dose aspirin combined with LMWH treatment of PE may be advantageous to improve blood pressure, 24-hour proteinuria and coagulation function, and it may reduce the adverse reactions in pregnant women without increasing adverse perinatal outcomes.

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Preeclampsia and the longitudinal risk of hospitalization for depression at 28 years

Cited by 12 publications

References 30 publications

The Transition From Maternity Blues to Full-Blown Perinatal Depression: Results From a Longitudinal Study

The Transition From Maternity Blues to Full-Blown Perinatal Depression: Results From a Longitudinal Study

Highlighting the Mechanistic Relationship Between Perinatal Depression and Preeclampsia: A Scoping Review

Efficacy and safety of low-dose aspirin combined with low-molecular-weight heparin in treatment of preeclampsia: a meta-analysis and systematic review

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