Preeclampsia as a Multifactorial Pregnancy Disorder: Clinical Symptoms,Diagnostic Tools and Research Strategies

Hass, Ralf; Staboulidou, I.; Wüstemann, M.; Kundu, Sudip; Oehler, Katrin; Scharf, A.

doi:10.2174/157340407781387645

CWHR

2007

DOI: 10.2174/157340407781387645

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Preeclampsia as a Multifactorial Pregnancy Disorder: Clinical Symptoms,Diagnostic Tools and Research Strategies

Ralf Hass¹,

I. Staboulidou²,

M. Wüstemann³

et al.

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2013

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“…Indeed, immunological maladaptation is the most probable trigger of the insult to the invading trophoblast, which also occurs early in the first trimester. This could result in a sustained activation of the immune system, 7 , 8 which imbalances metabolic pathways and interferes with important regulatory mechanisms such as apoptosis. In this context, normal placenta development is controlled by physiological apoptosis, which has a crucial role in the maintenance of tissue homeostasis and an intact pregnancy.…”

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confidence: 99%

Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome

et al. 2013

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HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome represents a life-threatening pregnancy disorder with high fetal and maternal mortality, but its underlying molecular mechanisms remain unknown. Although apoptosis has been implicated in HELLP syndrome, its pathogenic role remains largely unclear. In the present study, we investigated whether the detection of apoptosis by novel plasma biomarkers is of diagnostic value in HELLP patients. For this purpose, we analyzed two biomarkers that specifically detect apoptosis or overall cell death of epithelial cells, such as hepatocytes or placental trophoblasts, through the release of caspase-cleaved or total (caspase-cleaved and uncleaved) cytokeratin-18 (CK-18) in plasma of HELLP patients compared with pregnant as well as non-pregnant healthy women. In addition, caspase activation and cell death were determined in placental tissues of HELLP patients and individuals with normal pregnancy. In contrast to pregnant or non-pregnant healthy controls, we observed significantly increased levels of both caspase-cleaved and total CK-18 in plasma of HELLP patients. Following delivery, CK-18 levels rapidly decreased in HELLP patients. Caspase activation and cell death were also elevated in placental tissues from HELLP patients compared with healthy pregnant women. These data demonstrate not only that apoptosis is increased in HELLP syndrome, but also that caspase-cleaved or total CK-18 are promising plasma biomarkers to identify patients with HELLP syndrome. Thus, further studies are warranted to evaluate the utility of these biomarkers for monitoring disease activity in HELLP syndrome.

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Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome

et al. 2013

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Preeclampsia as a Multifactorial Pregnancy Disorder: Clinical Symptoms,Diagnostic Tools and Research Strategies

Cited by 1 publication

References 0 publications

Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome

Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome

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