Preeclampsia Brings the Risk of Premature Cardiovascular Disease in Women Closer to That of Men

Abstract

See editorial by Dayan and Udell, pages 13e16 of this issue.

Cardiovascular events following pregnancy complicated by pre‐eclampsia with emphasis on comparison between early‐ and late‐onset forms: systematic review and meta‐analysis

“…Overall, 73 studies were included in the systematic review 12,20,21,30–99 (Table S1, Figure 1, Table S2). The results of the quality assessment of the included studies using NOS are presented in Table S3.…”

“…Hubel (2000) 46 Irgens (2001) 12 Edlow (2009) 86 Mongraw-Chaffin (2010) 88 Skjaerven (2012) 62 Cirillo (2015) 91 van Rijn (2016) 57 Bokslag (2017) 58 Stuart (2018) 97 Leon (2019) 75 Langlois (2020) 40 Total (95% CI) Heterogeneity: tau-square, 0.19; chi-square, 77.84, df, 10 (P < 0.00001); I 2 , 87% Test for overall effect: Z-score, 7.73 (P < 0.00001) log(odds ratio) ). These results were confirmed when excluding studies without adjusted estimates.…”

Use of Race, Ethnicity, and National Origin in Studies Assessing Cardiovascular Risk in Women With a History of Hypertensive Disorders of Pregnancy

“…A total of 524 records were obtained from our second search for recently published primary studies. After excluding records that did not meet our eligibility criteria, a total of 124 primary studies 3 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , …”

Sex as a Key Variable in Predicting Cardiovascular Outcomes: Rapidly Evolving Knowledge but Much More Needed

“…However, Langlois et al show that the age-dependent CVD risk of women with preeclampsia approaches that of men, removing some of their sex-related protection. 14 Dayan and Udell raise the possibility that women with preeclampsia have a more "male" physiology than other women. 15 They raise the interesting possibility that biologic sex might be more than a simple binary variable and emphasize that gender may play a role and was not considered in the Langlois et al study.…”