Preeclampsia. Eclampsia. Anesthesia and intensive care in childbirth and the puerperium. Review

Pylaeva, N.Yu.; Shifman, E.М.; Куликов, А В; Артымук, Н В; Belokrinitskaya, T. E.; Phillipov, O.S.; Babich, Tanya

doi:10.21320/1818-474x-2020-1-41-52

Cited by 6 publications

(1 citation statement)

References 69 publications

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“…Тем не менее все еще продолжаются споры о степени значимости абсолютной количественной оценки ПУ [2,5].…”

Section: Introductionunclassified

Association Between Pre-delivery Proteinuria and Pregnancy and Delivery Outcome in Patients with Preeclampsia

Pylaeva¹,

Shifman²,

Kulikov³

et al. 2021

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Study Objective: To assess the association between pre-delivery proteinuria (PU) in patients with preeclampsia and pregnancy/ delivery outcomes for mother and child. Study Design: retrospective study. Materials and Methods. We have conducted a retrospective study of 149 labour and delivery medical records of patients with PU diagnosed before delivery, who had preeclampsia during their pregnancy. Patients were divided into two groups depending on PU severity: moderate and significant PU. We studied the rate of complications for mother and foetus, pregnancy/delivery outcomes for foetus, and anthropometric and demographic parameters of mothers, their somatic conditions, and obstetric history. Study Results. Women with significant PU diagnosed before delivery demonstrated higher statistically and clinically significant risk of HELLP syndrome, as well as increased AAT and ALT activity vs. patients with moderate PU. As for outcomes for newborns, there was a clear statistically significant association between respiratory disorders in child and rate of pre-delivery PU in mother. This complication was recorded more frequently in newborns born to mothers with significant PU vs. moderate PU. Conclusion. An absolute PU quantification before delivery is a method to forecast unfavourable outcomes for mother and child. Keywords: preeclampsia, moderate proteinuria, severe proteinuria, pregnancy and delivery outcomes

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“…Тем не менее все еще продолжаются споры о степени значимости абсолютной количественной оценки ПУ [2,5].…”

Section: Introductionunclassified

Association Between Pre-delivery Proteinuria and Pregnancy and Delivery Outcome in Patients with Preeclampsia

Pylaeva¹,

Shifman²,

Kulikov³

et al. 2021

Self Cite

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Pathogenetic role of a number of factors in the development and progression of preeclampsia with varying severity in pregnant women

Ismailova,

Zame,

Akhmedzhanova

et al. 2024

Reprod. Fertil. Dev.

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Context Preeclampsia is a common pregnancy complication, posing significant risks to both the mother and fetus. Predicting and determining the risks of this disease is crucial. Aims This research aims to understand the pathogenetic role of several factors in the development and progression of preeclampsia, particularly in relation to its severity in pregnant patients. Methods The study included 60 pregnant women diagnosed with either mild or severe preeclampsia and 40 healthy pregnant women for comparison. Blood plasma was analysed using biochemical methods, and blood microcirculation parameters were determined to identify homeostatic abnormalities in early preeclampsia. Key results A molecular genetic study revealed the frequency of the endothelial nitric oxide gene eNOSC774T. Homeostatic abnormalities were statistically correlated with polymorphic genotypes of the eNOSC774T gene. Conclusions The research found a correlation between the T774T eNOS genotype mutation and the severity of preeclampsia, alongside significant homeostasis abnormalities in patients. Implications The T774T mutant genotype of the eNOS gene and higher levels of lipid peroxidation products are strongly linked to the severity and progression of preeclampsia. This highlights a significant connection between genetic predisposition and biochemical abnormalities in the disease’s development.

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Antithrombin III — evolution from anticoagulant to a marker of severe preeclampsia

Pylaeva¹,

Shifman²,

Ponomareva³

et al. 2020

Anaes. i reanim.

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Preeclampsia. Eclampsia. Anesthesia and intensive care in childbirth and the puerperium. Review

Cited by 6 publications

References 69 publications

Association Between Pre-delivery Proteinuria and Pregnancy and Delivery Outcome in Patients with Preeclampsia

Association Between Pre-delivery Proteinuria and Pregnancy and Delivery Outcome in Patients with Preeclampsia

Pathogenetic role of a number of factors in the development and progression of preeclampsia with varying severity in pregnant women

Antithrombin III — evolution from anticoagulant to a marker of severe preeclampsia

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