Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

Molvarec, Attila; Kopper, László; Derzsy, Zoltán; Szarka, András; Halmos, Amrita; Stenczer, Balázs; Arnaúd, Philippe; Karádi, István; Prohászka, Zoltán; Rigó, János

doi:10.1038/hr.2009.79

Cited by 34 publications

(20 citation statements)

References 53 publications

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“…These results indicated that BMI was significantly higher in the PE group than that in the control group, as noted previously (15). Previous studies found that overweight and obese women have elevated risks of PE, cesarean delivery, and childhood obesity compared with normal-weight women (16).…”

Section: O R I G I N a L A R T I C L Esupporting

confidence: 75%

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Proteinuria as the Most Relevant Parameter Affecting Fetuin-A Levels in Preeclampsia

Al‐Hakeim¹,

Ali²

2015

Acta Facultatis Medicae Naissensis

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The present study aimed to examine the factors affecting the possible changes in serum fetuin-A in patients with preeclampsia (PE). The examined factors included the parameters of insulin resistance (IR) [(insulin sensitivity (HOMA%S), insulin resistance (HOMA2IR), and beta-cell functions (HOMA%B)], which were calculated using the HOMA2 calculator, and total and ionized calcium and magnesium levels.Sixty PE patients and thirty healthy pregnant women, which comprised the study group and control group, respectively participated in the present study. Fetuin-A, estradiol, insulin, glucose, total and ionized calcium and magnesium, total protein, albumin, and globulins were measured in their sera.The results of the present study showed that serum total and ionized magnesium and the I.Ca/Mg ratio decreased in PE women. Although the fasting insulin level and HOMA2IR were higher and HOMA2%S was lower in PE compared with the control women, PE did not appear as an overt insulin-resistant state. Serum fetuin-A was low in PE patients compared with the control group because PE women had proteinuria. Fetuin-A levels were not correlated with the characteristics and IR parameters, cations, and estradiol levels, but it was correlated with the severity of proteinuria.These results confirmed the hypothesis that proteinuria results in the loss of fetuin-A because it has a low molecular weight.

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Section: O R I G I N a L A R T I C L Esupporting

confidence: 75%

“…This decrease may be due to the fact that all PE women had proteinuria, and fetuin-A was excreted in urine with other small-molecular-weight proteins. Low fetuin-A was also reported in other studies (15,29). Furthermore, fetuin-A has been implicated in the pathophysiology of PE (7,8).…”

Section: Sfetuin-a In Patients and Controlsmentioning

confidence: 51%

Proteinuria as the Most Relevant Parameter Affecting Fetuin-A Levels in Preeclampsia

Al‐Hakeim¹,

Ali²

2015

Acta Facultatis Medicae Naissensis

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“…Thirty‐two studies in total reported on C‐reactive protein levels,21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 of which 17 were applicable for meta‐analysis 21, 22, 23, 29, 30, 31, 32, 33, 34, 37, 38, 39, 41, 42, 47, 49, 50. A significantly higher C‐reactive protein was found in women with pre‐eclampsia than in non‐hypertensive controls ( Figure 2), and this correlation was stronger in severe than in mild pre‐eclampsia ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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“…2 The development of pre-eclampsia is influenced by both genetic and environmental risk factors, suggesting its multifactorial inheritance. [3][4][5][6][7][8][9][10][11][12] Soluble fms-like tyrosine kinase-1 (sFlt-1), the naturally occurring soluble form of vascular endothelial growth factor receptor 1 (VEGFR1), is produced by alternative splicing of the Flt-1 transcript, resulting in a deletion of the intracellular and transmembrane domains of Flt-1. sFlt-1 binds VEGF and placental growth factor (PlGF) with high affinity, acting as a soluble trap of these angiogenic factors.…”

Section: Introductionmentioning

confidence: 99%

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

et al. 2010

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The purpose of this study was to determine whether increased serum soluble fms-like tyrosine kinase-1 (sFlt-1) and decreased placental growth factor (PlGF) levels in pre-eclampsia are related to the clinical features and laboratory parameters of the patients, including markers of inflammation, endothelial activation and injury, oxidative stress and trophoblast debris. A total of 54 pre-eclamptic patients, 58 healthy pregnant and 52 healthy non-pregnant women were involved in this case-control study. Serum sFlt-1 and PlGF levels were measured by electrochemiluminescence immunoassay. Serum levels of sFlt-1 and PlGF were significantly higher in pre-eclamptic patients and healthy pregnant women than in healthy non-pregnant women. In addition, pre-eclamptic patients had significantly higher sFlt-1 levels and significantly lower PlGF concentrations compared with healthy pregnant women. According to the subgroup analyses, sFlt-1 levels were significantly higher in severely pre-eclamptic patients than in those with mild pre-eclampsia, whereas pre-eclamptic patients with fetal growth restriction or preterm onset of the disease had significantly lower PlGF concentrations compared with those without intrauterine growth restriction or with a disease onset at term. In the pre-eclamptic group, there were significant positive correlations between serum sFlt-1 levels and systolic and diastolic blood pressure, serum levels of blood urea nitrogen and creatinine, as well as plasma levels of von Willebrand factor antigen, fibronectin and cell-free fetal DNA. Furthermore, serum PlGF concentrations of pre-eclamptic patients showed significant positive correlations with gestational age at disease onset and delivery, as well as with fetal birth weight, and significant inverse correlations with levels of blood urea nitrogen, creatinine and fibronectin. In conclusion, increased serum sFlt-1 and decreased PlGF levels are associated with blood pressure, renal and endothelial dysfunction, trophoblast deportation, as well as with a shorter duration of pregnancy, fetal growth restriction, the severity and preterm onset of the disease in pre-eclampsia. These findings indicate the central role of an angiogenic imbalance in the pathogenesis of this pregnancy-specific disorder.

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Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

Cited by 34 publications

References 53 publications

Proteinuria as the Most Relevant Parameter Affecting Fetuin-A Levels in Preeclampsia

Proteinuria as the Most Relevant Parameter Affecting Fetuin-A Levels in Preeclampsia

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

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