Preeclampsia Is Associated with Lower Production of Vascular Endothelial Growth Factor by Peripheral Blood Mononuclear Cells

Cárdenas-Mondragón, María G.; Vallejo-Flores, Gabriela; Delgado-Domínguez, José; Romero-Arauz, Juan Fernando; Gómez‐Delgado, Alejandro; Aguilar-Madrid, Guadalupe; Sánchez‐Barriga, Juan Jesús; Márquez-Acosta, Janeth

doi:10.1016/j.arcmed.2014.10.004

Cited by 14 publications

(9 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…35,36 VEGF is also reported to be important for normal placental development, trophoblast proliferation and embryonic vasculature development. 37 Reduced maternal PE and increased sFlt-1 were found in women with PE compared with normotensive women. 38 Consistent with these previous studies, VitD treatment decreased sFlt-1 and lowered high blood pressure and uterine perfusion pressure in a rat PE model.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Jing

2016

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 94%

“…There is increasing evidence that imbalance in angiogenic factors may be the cause of PE . VEGF is also reported to be important for normal placental development, trophoblast proliferation and embryonic vasculature development . Reduced maternal PE and increased sFlt‐1 were found in women with PE compared with normotensive women .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Jing

2016

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…) and isolated PBMC's (Cardenas‐Mondragon et al. ) of preeclamptic women compared to normal pregnant women. It has also been well established that VEGF is important for proper endothelial function (Kroll and Waltenberger ; Kliche and Waltenberger ).…”

Section: Discussionmentioning

confidence: 99%

Chronic infusion of interleukin‐17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats

et al. 2019

View full text Add to dashboard Cite

Previous studies by our lab have established that placental‐ischemia stimulated T‐helper 17 cells ( T H 17s) cause increased cytolytic natural killer ( cNK ) cell proliferation and activation during pregnancy; however, the exact mechanism is unknown. The objective of this study was to investigate the role of interlukin 17 ( IL ‐17) in inducing cNK cell activation in pregnancy. We infused 150 pg/day of recombinant IL ‐17 into a subset of normal pregnant ( NP ) Sprague Dawley rats from gestation day ( GD ) 12–19 ( NP + IL ‐17). On GD 19, mean arterial pressure ( MAP ), fetal and placental weights, cytokines, cNK cell activation, cytotoxic enzymes, and vascular reactivity were assessed. MAP significantly increased from 99 ± 3 mmHg in NP to 120 ± 1 mmHg in NP + IL ‐17 ( P < 0.05). Fetal weight significantly decreased from 2.52 ± 0.04 g in NP to 2.32 ± 0.03 g in NP + IL ‐17 as did placental weight ( NP : 0.65 ± 0.03 g; NP + IL ‐17: 0.54 ± 0.01 g, P < 0.05). Plasma levels of TNF ‐ α increased to 281.4 ± 55.07 pg/ mL in NP + IL ‐17 from 145.3 ± 16.03 pg/ mL in NP ( P < 0.05) while placental levels of VEGF decreased from 74.2 ± 6.48 pg/mg in NP to 54.2 ± 3.19 pg/mg in NP + IL ‐17. Total NK cells were increased in the placenta ( NP : 14.3 ± 3.49%; NP + IL ‐17: 29.33 ± 2.76%, P < 0.05) as were cytolytic NK cells ( NP : 3.31 ± 1.25%; NP + IL ‐17: 13.41 ± 1.81%, P < 0.05). A similar trend was observed in circulating NK cells. Plasma granzyme K increased from 3.55 ± 2.29 pg/ mL in NP to 20.9 ± 7.76 pg/ mL in NP + IL ‐17 ( P < 0.05), and plasma granzyme B increased from 10.95 ± 0.64 pg/ mL in NP to 14.9 ± 0.98 pg/ mL in NP + IL ‐17( P < 0.05). In the plac...

show abstract

“…SNPs in the vascular endothelial growth factor ( VEGF ) gene are also largely studied in PE. Importantly, the low production of VEGF by peripheral blood mononuclear cells is associated with PE (Cardenas-Mondragon et al, 2014). The possible role of SNPs at the promoter region of VEGF was addressed by Sandrim et al (2009).…”

Section: Genetic Studies In Latin-american Populationsmentioning

confidence: 99%

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Michita

Kaminski

2018

Front. Physiol.

View full text Add to dashboard Cite

Placental vascularization is a tightly regulated physiological process in which the maternal immune system plays a fundamental role. Vascularization of the maternal-placental interface involves a wide range of mechanisms primarily orchestrated by the fetal extravillous trophoblast and maternal immune cells. In a healthy pregnancy, an immune cross-talk between the mother and fetal cells results in the secretion of immunomodulatory mediators, apoptosis of specific cells, cellular differentiation/proliferation, angiogenesis, and vasculogenesis, altogether favoring a suitable microenvironment for the developing embryo. In the context of vasculopathy underlying common pregnancy disorders, it is believed that inefficient invasion of extravillous trophoblast cells in the endometrium leads to a poor placental blood supply, which, in turn, leads to decreased secretion of angiogenic factors, hypoxia, and inflammation commonly associated with preterm delivery, intrauterine growth restriction, and preeclampsia. In this review, we will focus on studies published by Latin American research groups, providing an extensive review of the role of genetic variants from candidate genes involved in a broad spectrum of biological processes underlying the pathophysiology of preeclampsia. In addition, we will discuss how these studies contribute to fill gaps in the current understanding of preeclampsia. Finally, we discuss some trending topics from important fields associated with pregnancy vascular disorders (e.g., epigenetics, transplantation biology, and non-coding RNAs) and underscore their possible implications in the pathophysiology of preeclampsia. As a result, these efforts are expected to give an overview of the extent of scientific research produced in Latin America and encourage multicentric collaborations by highlighted regional research groups involved in preeclampsia investigation.

show abstract

Preeclampsia Is Associated with Lower Production of Vascular Endothelial Growth Factor by Peripheral Blood Mononuclear Cells

Cited by 14 publications

References 54 publications

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Chronic infusion of interleukin‐17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Contact Info

Product

Resources

About