Preeclampsia Management and Maternal Ophthalmic Artery Doppler Measurements between 19 and 23 Weeks of Gestation

Gyokova, Elitsa; Hristova-Atanasova, Eleonora; Iskrov, Georgi

doi:10.3390/jcm13040950

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination of these factors can lead to different obstetric complications, such as habitual abortions, fetal death, restricted fetal growth, placental disorders such as calcification or abruption, and hypertension disorders, resulting in conditions such as preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. These multifaceted influences highlight the intricate nature of thromboembolic pathophysiology during pregnancy and stress the significance of thorough risk assessment and treatment options [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

Hristova

2024

Cureus

View full text Add to dashboard Cite

Thrombophilias, which include both hereditary and acquired illnesses, are a range of abnormalities that make persons more prone to developing thromboembolism. Thrombophilic conditions carry significant dangers during pregnancy, such as miscarriage in early pregnancy, intrauterine growth restriction, abruptio placenta, and preeclampsia. According to compiled statistics, an average of 15%-20% of pregnancies end in miscarriage. While the risk of miscarriage in a first pregnancy is 11%, this risk increases to between 13% and 17% in subsequent pregnancies, and after the third miscarriage, it reaches 38%. This research article presents a detailed case report that focuses on a patient who has experienced three previous failed pregnancies. The patient's genetic analysis indicates that she has two copies of a mutated version of the methylenetetrahydrofolate reductase ( MTHFR ) gene (Ala222Val) and a variation in the plasminogen activator inhibitor 1 ( PAI-1 ) gene known as 4G/5G. In addition, an evaluation of immunological characteristics revealed increased amounts of natural killer (NK) cells with enhanced activity, along with the identification of embryotoxins in a blood test that suppress embryotoxicity in a blood test, assisted by DNA isolation and real-time polymerase chain reaction (PCR) DNA analysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

Hristova

2024

Cureus

View full text Add to dashboard Cite

show abstract

Therapeutic Value of Low-Dose Acetylsalicylic Acid for the Prevention of Preeclampsia in High-Risk Bulgarian Women

Stoilov,

Uchikova,

Kirovakov

et al. 2024

Cureus

View full text Add to dashboard Cite

IntroductionPreeclampsia (PE) is a syndrome that affects pregnant women after 20 weeks of gestation and involves numerous organ systems. Screening for PE is essential to prevent complications and guide management. Some existing guidelines for screening have limitations in terms of detection rates and false positives. The aim of this study is to assess the therapeutic value of low-dose acetylsalicylic acid (ASA) for the prevention of PE in high-risk Bulgarian women. MethodologyA prospective cohort research was carried out, encompassing women who were recruited from several routine consultations, such as booking, scanning, and regular prenatal visits. We utilized the purposive sampling technique to carefully choose potential participants. The study was conducted by a maternal-fetal medicine center located in Plovdiv, Bulgaria. The data-gathering period spanned from January 2018 to November 2020. At the appointment, the following procedures were conducted: 1) recording history; 2) assessing height, weight, and blood pressure; 3) collecting blood specimens for biochemical markers; and 4) ultrasound examination. ResultsA total sample size of 1,383 individuals was categorized into two distinct groups: high-risk patients (n = 506) and low-risk patients (n = 877). The mean uterine artery pulsatility index (UtA-PI) and mean arterial pressure (MAP) ratios were all greater in high-risk group women (p < 0.05). The data revealed that a significant number of high-risk women failed to adhere to the prescribed dosage or regular use of ASA as recommended by their doctor. There were only 384 (75.9%) high-risk women who took low-dose ASA regularly. ConclusionThe findings emphasize the importance of personalized prenatal care and early risk assessment to improve maternal and fetal outcomes. Therefore, it is crucial to educate pregnant women, considering the benefits and risks of low-dose ASA when appropriately indicated.

show abstract

Preeclampsia Management and Maternal Ophthalmic Artery Doppler Measurements between 19 and 23 Weeks of Gestation

Cited by 2 publications

References 35 publications

Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

Therapeutic Value of Low-Dose Acetylsalicylic Acid for the Prevention of Preeclampsia in High-Risk Bulgarian Women

Contact Info

Product

Resources

About