Preeclampsia: state of art and future perspectives. A special focus on possible preventions

Kahramanoğlu, Özge; Schiattarella, Antonio; Demirci, Oya; Sisti, Giovanni; Ammaturo, Franco Pietro; Trotta, Carlo; Ferrari, Federico; Rapisarda, Agnese Maria Chiara

doi:10.1080/01443615.2022.2048810

Cited by 17 publications

(13 citation statements)

References 121 publications

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“…The criteria for determining delivery timing include the severity of the disease, gestational week, maternal and fetal conditions. Expectant management with a close arterial blood pressure check and clinical monitoring should be considered in non-severe cases [25]. However, there is no a wide consensus regarding the blood pressure cut-offs for the diagnosis and follow-up.…”

Section: Discussionmentioning

confidence: 99%

Postpartum HELLP syndrome associated with posterior reversible encephalopathy syndrome: a case report and literature review

Incognito¹,

Genovese²,

Incognito³

et al. 2023

Ital J Gynaecol Obstet

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Background: Hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is a lifethreatening pregnancy complication. Various mechanism may lead to diffuse endothelial damage which causes multi-organ dysfunctions, with possible brain involvement. We report a rare case of postpartum HELLP syndrome associated with posterior reversible encephalopathy syndrome (PRES) and conducted a literature review from the PubMed, Embase, and Cochrane databases to summarize the clinical, laboratory and radiological characteristics. We found only 10 papers describing this association occurring during pregnancy and 7 articles in the post-partum.Case presentation: Our patient developed brief hypertensive peaks followed by two episodes of generalized tonic-clonic convulsions during postpartum. Brain magnetic resonance imaging allowed the diagnosis of PRES and an association with HELLP syndrome was established after blood exams. After medical therapy, the follow-up was marked by full recovery. Conclusion:Patients with PRES do not always show typical manifestations and MRI is crucial for its diagnosis. Cases of postpartum PRES with involvement of anterior brain regions after HELLP syndrome are rare but must be considered and they should be kept in mind as a differential diagnosis in women presenting with seizures, headache and altered mentation. Clinicians should be aware of this neurological syndrome because prompt diagnosis and treatment may result in complete resolution.

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Section: Discussionmentioning

confidence: 99%

Postpartum HELLP syndrome associated with posterior reversible encephalopathy syndrome: a case report and literature review

Incognito¹,

Genovese²,

Incognito³

et al. 2023

Ital J Gynaecol Obstet

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“…Placental pathologies, placental shape abnormalities, and related maternal and fetal risk factors have been widely discussed in recent years [20][21][22][23][24]. In this paper, we focused on bilobed placenta, to deepen the most controversial aspects of this condition.…”

Section: Discussionmentioning

confidence: 99%

Bilobed placenta and management choices: liture review and two cases studies

Calagna¹,

Polito²,

Schiattarella³

et al. 2023

It Journ Gyn Obs

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“…Thus, an accurate and feasible severity -assessment strategy will reduce the disease burden, which can be accomplished by early preventive strategies, close anti-natal surveillance, and prophylactic interventions. Currently, the combination of anamnestic, anthropometric, biophysical, and maternal biochemical variables is the most recommended screening method [16].…”

Section: Discussionmentioning

confidence: 99%

The capacity of RDW and Platelet indices in defining pre-eclampsia severity: a cases-control study

Nori¹,

Hussein²,

Salman³

et al. 2023

It Journ Gyn Obs

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Objective. Pre-eclampsia (PE) is a peculiar pregnancy complication with adverse feto-maternal outcomes. Red blood cell distribution width (RDW) and platelet indices are complete blood count parameters; tested as a marker for cardiovascular diseases. The inflammatory theory was proposed for PE etiology; therefore, we aimed to investigate the role of RDW and platelet parameters in determining preeclampsia severity.Patients and methods. At Al-Yarmouk Hospital, we conducted a case-control study. 120 pregnant women satisfied inclusion criteria, divided into two groups. According to American guidelines, PE cases (60/120) and healthy controls (60/120).PE cases were subdivided into severe PE (34/60) and non-severe PE (26/60) cases. A blood sample was aspirated for complete blood count, including RDW, mean platelet volume (MPV), and platelet distribution width (PDW).Results. RDW and MPV were meaningfully higher in PE cases than controls, with a P-value of 0.003 and 0.004, respectively. A significant difference was found in the RDW and PDW in subgroups analysis of severe vs. non-severe PE cases, with Pvalues of 0.001 and 0.037, respectively. Only RDW was significantly correlated with systolic BP; r = 0.47. and diastolic BP; r = 0.399. At a cutoff value of > 15.6%, RDW showed 56.7 %sensitivity and 95.8 % specificity, P < 0.001, distinguishing severe from non-severe PE pregnancies.Conclusions. RDW discriminated PE severity with good accuracy and preceded platelets indices, implying its validity as a marker of severe PE. RDW is a simple, inexpensive test available in antenatal care services. Accurate diagnosis permits early focused treatment, vigorous monitoring, and timely interventions for improving pregnancy outcomes.

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Preeclampsia: state of art and future perspectives. A special focus on possible preventions

Cited by 17 publications

References 121 publications

Postpartum HELLP syndrome associated with posterior reversible encephalopathy syndrome: a case report and literature review

Postpartum HELLP syndrome associated with posterior reversible encephalopathy syndrome: a case report and literature review

Bilobed placenta and management choices: liture review and two cases studies

The capacity of RDW and Platelet indices in defining pre-eclampsia severity: a cases-control study

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