Preeklampsi ile komplike olmuş gebelerde 24 saatlik idrarda proteinüri değerlerinin maternal ve perinatal sonuçlar üzerine etkisi

Abstract

Aim: This study aimed to evaluate the relation of 24-hour proteinuria (PU) levels in preeclamptic patients with maternal and perinatal outcomes. Materials and Methods:Patients who were hospitalized with the diagnosis of preeclampsia (n=97) were divided into three groups as mild (0.3-2 g), severe (2-5 g), and massive (≥5 g) PU, according to their 24-hour PU levels. The patients' descriptive and clinical data, prenatal and postnatal blood and urine biochemistry results, inputs about the weeks of birth, and hospitalizations, birth information of the newborn were obtained from the patient files, and comparison and relationship analyzes were performed between three PU groups.Results: There were 41, 17, and 34 patients in the mild, severe, and massive PU groups, respectively. The mean 24-hour PU amount of the patients before delivery was 4776.4±5616.6 (mg/dL). Besides, 20% of the mothers developed complications in the postpartum period. Age, red cell distribution width (RDW), and duration from hospitalization to birth were significantly lower in the severe PU group than the mild PU group. In the massive PU group, AST and cord pH were lower than in the mild PU group; but BUN, creatinine, and WBC were higher. A statistically significant increase was observed only in the creatinine level in the massive PU groups, in comparison with the severe PU group. Conclusion:In severe and massive PU groups, BUN, WBC, and creatinine levels are higher, cord pH is lower. Long-term and further studies are needed to determine whether BUN and creatinin values that show renal function affect long-term maternal renal function and the effect of low umbilical cord pH value at birth on long-term outcomes of newborns.