Preempting Bronchopulmonary Dysplasia: Time to Focus on the Placenta?

Thébaud, Bernard

doi:10.1165/rcmb.2021-0472ed

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Clinical antenatal conditions such as preeclampsia and chorioamnionitis are associated with an increased risk of neonatal BPD, and it has further been suggested that these conditions can potentially lead to the develop of different BPD phenotypes [32][33][34]. Preeclampsia is a placental dysfunction that leads to the release of anti-angiogenic and pro-inflammatory mediators, which can affect both the mother and the fetus.…”

Section: Deconstructing the Developing Lung At The Single Cell Level ...mentioning

confidence: 99%

ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

et al. 2023

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In this review the Basic and Translational Science Assembly of the European Respiratory Society (ERS) provides an overview of the 2022 international conference highlights. We discuss the consequences of respiratory events from birth until old age regarding climate change-related alterations in air quality due to pollution caused by increased ozone, pollen, wildfires and fuel combustion as well as the increasing presence of microplastic and microfibres. Early life events such as the effect of hyperoxia in the context of bronchopulmonary dysplasia and crucial effects of the intrauterine environment in the context of preeclampsia were discussed. The Human Lung Cell Atlas (HLCA) was put forward as a new point of reference for healthy human lungs. The combination of single-cell RNA-sequencing and spatial data in the HLCA has enabled the discovery of new cell types/states, new niches and served as a platform that facilitates further investigation of mechanistic perturbations. The role of cell death modalities in regulating the onset and progression of chronic lung diseases and its potential as a therapeutic target was also discussed. Translational studies identified novel therapeutic targets and immunoregulatory mechanisms in asthma. Lastly, it was highlighted that the choice of regenerative therapeutic depends on disease severity, ranging from transplantation to cell therapies and regenerative pharmacology.

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Section: Deconstructing the Developing Lung At The Single Cell Level ...mentioning

confidence: 99%

ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

et al. 2023

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Section: Endotypes Of Very and Extremely Preterm Birth: Definition An...mentioning

confidence: 99%

“…Regarding placental dysfunction, it has been suggested that both the fetal lung and the placenta have similar responses to alterations in the intrauterine environment [ 35 , 45 ]. This may be particularly true for responses to hypoxia [ 35 , 45 ]. Preclinical models of placental dysfunction show profound impairment in alveolar and lung vascular growth, even in the absence of postnatal adverse exposures [ 35 , 36 , 39 , 45 , 46 ].…”

Section: Endotypes Of Very and Extremely Preterm Birth: Definition An...mentioning

confidence: 99%

“…This may be particularly true for responses to hypoxia [ 35 , 45 ]. Preclinical models of placental dysfunction show profound impairment in alveolar and lung vascular growth, even in the absence of postnatal adverse exposures [ 35 , 36 , 39 , 45 , 46 ]. Growing evidence suggests that the pathogenesis of these alterations involves a complex interplay of pro- and antiangiogenic factors, oxidative stress, epigenetic alterations, and activation of the endoplasmic reticulum stress pathway [ 35 , 36 , 39 , 45 , 46 ].…”

Section: Endotypes Of Very and Extremely Preterm Birth: Definition An...mentioning

confidence: 99%

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Endotypes of Prematurity and Phenotypes of Bronchopulmonary Dysplasia: Toward Personalized Neonatology

Pierro

Mechelen

Westering-Kroon

et al. 2022

JPM

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Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is increasingly recognized as the consequence of a pathological reparative response of the developing lung to both antenatal and postnatal injury. According to this view, the pathogenesis of BPD is multifactorial and heterogeneous with different patterns of antenatal stress (endotypes) that combine with varying postnatal insults and might distinctively damage the development of airways, lung parenchyma, interstitium, lymphatic system, and pulmonary vasculature. This results in different clinical phenotypes of BPD. There is no clear consensus on which are the endotypes of prematurity but the combination of clinical information with placental and bacteriological data enables the identification of two main pathways leading to birth before 32 weeks of gestation: (1) infection/inflammation and (2) dysfunctional placentation. Regarding BPD phenotypes, the following have been proposed: parenchymal, peripheral airway, central airway, interstitial, congestive, vascular, and mixed phenotype. In line with the approach of personalized medicine, endotyping prematurity and phenotyping BPD will facilitate the design of more targeted therapeutic and prognostic approaches.

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“…Recent evidence from a murine model of the early onset immune-mediated subtype of Pre-E suggests that the placenta plays a key role in mediating the effects of Pre-E on fetal lung development. 6,7 Disruption of pulmonary vascular development is linked to impaired alveolar growth, a hallmark feature of bronchopulmonary dysplasia (BPD). Increased cord blood sFlt-1 is also associated with an enhanced risk of BPD in preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Forced expiratory flows and diffusion capacity in infants born from mothers with pre‐eclampsia

Ren

Slaven

Haas

et al. 2022

Pediatric Pulmonology

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Rationale Animal models suggest pre‐eclampsia (Pre‐E) affects alveolar development, but data from humans are lacking. Objective Assess the impact of Pre‐E on airway function, diffusion capacity, and respiratory morbidity in preterm and term infants born from mothers with Pre‐E. Methods Infants born from mothers with and without Pre‐E were recruited for this study; term and preterm infants were included in both cohorts. Respiratory morbidity in the first 12 months of life was assessed through monthly phone surveys. Raised volume rapid thoracoabdominal compression and measurement of diffusion capacity of the lung to carbon monoxide (DLCO) were performed at 6 months corrected age. Measurements and Main Results There were 146 infants in the Pre‐E cohort and 143 in the control cohort. The Pre‐E cohort was further divided into nonsevere (N = 41) and severe (N = 105) groups. There was no significant difference in DLCO and DLCO/alveolar volume among the three groups. Forced vital capacity was similar among the three groups, but the nonsevere Pre‐E group had significantly higher forced expiratory flows than the other two groups. After adjusting for multiple covariates including prematurity, the severe Pre‐E group had a lower risk for wheezing in the first year of life compared to the other two groups. Conclusions Pre‐E is not associated with reduced DLCO, lower forced expiratory flows, or increased wheezing in the first year of life. These results differ from animal models and highlight the complex relationships between Pre‐E and lung function and respiratory morbidity in human infants.

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Preempting Bronchopulmonary Dysplasia: Time to Focus on the Placenta?

Cited by 6 publications

References 25 publications

ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

Endotypes of Prematurity and Phenotypes of Bronchopulmonary Dysplasia: Toward Personalized Neonatology

Forced expiratory flows and diffusion capacity in infants born from mothers with pre‐eclampsia

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