Preemptive analgesic efficacy of dexketoprofen trometamol on impacted third molar surgery

Çağiran, Esra; Eyigör, Can; Sezer, Bahar; Uyar, Meltem

doi:10.5505/agri.2014.55265

Cited by 9 publications

(7 citation statements)

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“…of DEX (Eroglu, Durmus, & Kiresi, ; Esparza‐Villalpando et al, ; Iohom, Walsh, Higgins, & Shorten, ; Kara, Tuncer, Erol, & Reisli, ; Kesimci, Gümüs, & Kanbak, ), while the other studies employed intravenous (i.v.) administration (Atalay, Dogan, & Kizilkaya, ; Bolat, Erhan, & Deniz, ; Çağiran, Eyigör, & Sezer, ; Gelir, ; Gülhaş et al, ; Kadıoğlu, Tüker, Gurbet, Demirci, & Hülagü, ; Kelsaka, Guldogus, & Cetinoglu, ; Sagiroglu, ; Ozer et al, ). Eight studies utilized DEX 50 mg (Atalay et al, ; Bolat et al, ; Çağiran et al, ; Gelir, ; Gülhaş et al, ; Kadıoğlu et al, ; Kelsaka et al, ; Ozer et al, ), while the remaining studies evaluated DEX 25 mg (Esparza‐Villalpando et al, ; Iohom et al, ; Kara et al, ; Kesimci et al, ; Ozer et al, ; Sagiroglu, ).…”

Section: Resultsmentioning

confidence: 99%

“…Nine articles reported this comparison (Atalay et al,; Bolat et al, ; Çağiran et al, ; Gelir, ; Gülhaş et al, ; Iohom et al, ; Kara et al, ; Kesimci et al, ; Kelsaka et al, ). Age of the patients included in these studies ranged from 18 to 85 years.…”

Section: Qualitative Synthesismentioning

confidence: 99%

“…The surgical protocol and the administration routes were different between the studies. Five studies evaluated oral administration ( Nine articles reported this comparison (Atalay et al,2012;Bolat et al, 2013;Ça giran et al, 2014;Gelir, 2016;G€ ulhaş et al, 2011;Iohom et al, 2002;Kara et al, 2011;Kesimci et al, 2011;Kelsaka et al, 2014).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta‐analysis

Esparza-Villalpando

Pozos‐Guillén

Masuoka

et al. 2017

Drug Development Research

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Post-Market Research Clinical evidence supports the use of dexketoprofen trometamol (DEX) to manage acute postoperative pain. However, controversies surround the impact of the use of this drug in preoperative analgesic protocols. The aim of the present meta-analysis was to evaluate the effectiveness of the preoperative administration of DEX under postoperative pain conditions. Electronic and manual searches were conducted through diverse electronic databases. A systematic review and meta-analysis to evaluate the analgesic efficacy of the preoperative administration of DEX was performed including Randomized Clinical Trials (RCTs) published between 2002 and 2017. Suitable individual studies were evaluated through a quality system, and the data were extracted and analyzed. Fourteen RTCs were included (12 parallel trials and 2 cross-over trials), published in the English and Turkish languages. Follow-up periods ranged from 4, 6, 8, 24, and 48 hr. All trials measured the outcome result as Acute Pain Level (APL) (VAS, NRS, VRS), time to requiring a second dose of DEX or analgesic emergency and consumption of opioids via patient-controlled analgesia. When the comparators were other drugs - paracetamol, Lornoxicam or placebo during the preoperative time, preoperative administration of DEX was superior. When the comparison comprised preoperative and postoperative DEX, both alternatives exhibited comparable analgesic effects. The analgesic efficacy of the preoperative administration of DEX when compared to placebo, lornoxicam, and paracetamol on postoperative pain was evident. Preoperative administration of DEX compared to its immediate postoperative administration showed a similar analgesic effect.

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Section: Resultsmentioning

confidence: 99%

Section: Qualitative Synthesismentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta‐analysis

Esparza-Villalpando

Pozos‐Guillén

Masuoka

et al. 2017

Drug Development Research

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“…Jackson and colleagues found that analgesic efficacy of 25 mg dexketoprofen trometamol was similar to 50 mg refocoxib, and superior to placebo (27). In the study by Çağıran and colleagues preoperative intravenous 50 mg dexketoprofen trometamol was found to be more effective than placebo (28). Eroglu and colleagues reported that 12.5 mg dexketoprofen trometamol had similar analgesic effect with 500 mg paracetamol (24).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: Randomised clinical trial

Ciğerim

Kaplan²

2018

Med Oral

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BackgroundPostoperative pain is one of the most common complications. The aim of this study is to evaluate the analgesic efficacies of dexketoprofen trometamol and two different dosages of dexketoprofen trometamol + thiocolchicoside combination in the impacted third molar tooth operation.Material and MethodsThis randomized, double-blind study included 75 patients who did not have any disease. Patients were assigned to 3 groups. Group 1 received 25 mg dexketoprofen trometamol + 4 mg thiocholchicoside, Group 2 received 25 mg dexketoprofen trometamol +8 mg thiocholchicoside, and Group 3 received 25 mg dexketoprofen trometamol. In each group, the analgesic medication was administered twice a day, starting 1 hour before the operation. The level of pain was assessed with VAS.ResultsPatient age varied from 18 to 36 years. Of all patients, 59.2% (n=42) were female and 40.8% (n=29) were male. Drug side effects were observed in 28.17% (n=20) of the patients. Mean 24th hour VAS score was lower in dexketoprofen trometamol + 8 mg thiocolchicoside group compared to dexketoprofen trometamol group (p<0.05). There was no statistically significant difference between the three groups regarding drug side effects (p>0.05).ConclusionsDexketoprofen trometamol + 8 mg thiocolchicoside combination has higher analgesic efficacy compared to dexketoprofen trometamol. More studies are needed to interpret the analgesic and anti-inflammatory effects of thiocholchicoside + dexketoprofen trometamol combination. Key words:Analgesic, dexketoprofen trometamol, thiocolchicoside, third molar surgery.

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“…In another study, dexketoprofen trometamol was used in an intravenous preparation preoperatively and was found to have an excellent preemptive decrease in pain and swelling caused by third molar surgery. 13,14 The need for the use of postoperative narcotic medications for breakthrough pain is better controlled with the preemptive use of NSAIDs.…”

Section: Nonsteroidal Antiinflammatory Drugs and Postoperative Pain Cmentioning

confidence: 99%

Best Practices for Management of Pain, Swelling, Nausea, and Vomiting in Dentoalveolar Surgery

Drew¹

2015

Oral and Maxillofacial Surgery Clinics of North America

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Preemptive analgesic efficacy of dexketoprofen trometamol on impacted third molar surgery

Abstract: Preemptive use of IV DT is more effective than placebo for using as preemptive analgesia for acute postoperative pain control in patients underwent removal of an impacted mandibular third molar surgery.

Cited by 9 publications

References 0 publications

Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta‐analysis

Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta‐analysis

Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: Randomised clinical trial

Best Practices for Management of Pain, Swelling, Nausea, and Vomiting in Dentoalveolar Surgery

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