2014
DOI: 10.1007/s11845-014-1122-3
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Preemptive dexmedetomidine to prevent propofol injection pain in children

Abstract: Pretreatment with dexmedetomidine 0.6 μg/kg, then midazolam 0.06 mg/kg could suppress propofol injection pain in children.

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Cited by 8 publications
(6 citation statements)
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“…Given the discomfort caused by a tourniquet, lidocaine was slowly injected without a tourniquet in this trial. Nevertheless, a recent study used a mixture of lidocaine and propofol to pretreat injection pain, and it did not alleviate the propofol injection pain (25). In our study, the incidence of injection pain was reduced from 94% (control group) to 71% (40 mg lidocaine group), which suggested lidocaine pre-administration prior to anesthesia is effective in pain relief.…”
Section: Discussioncontrasting
confidence: 70%
“…Given the discomfort caused by a tourniquet, lidocaine was slowly injected without a tourniquet in this trial. Nevertheless, a recent study used a mixture of lidocaine and propofol to pretreat injection pain, and it did not alleviate the propofol injection pain (25). In our study, the incidence of injection pain was reduced from 94% (control group) to 71% (40 mg lidocaine group), which suggested lidocaine pre-administration prior to anesthesia is effective in pain relief.…”
Section: Discussioncontrasting
confidence: 70%
“…The incidence of propofol-induced injection pain (PIP) varies from approximately 28 to 90%. [1][2][3] To reduce the incidence of PIP, many techniques have been developed, including pre-treatment or mixed use with medium-chain and long-chain triglycerides, 4 pre-treatment or mixed use with lidocaine, [5][6][7][8][9] nonsteroidal anti-inflammatory drugs, 10 magnesium sulfate, 6,11 dexmedetomidine, 12 opioids, [13][14][15][16] or ketamine. 11,17 Although these strategies relieved PIP in varying degrees, the adverse event of these drugs such as emergence agitation, 18 laryngospasm, 19 pulmonary embolism, 20 gastrointestinal ulcer, 10 lengthy onset 21 or tinnitus and dizziness 22 limit their widespread clinical use.…”
Section: Introductionmentioning
confidence: 99%
“…Peripheral nerve fibers sense nociceptive information and transfer it onward. Based on this mechanism, many techniques have been developed to reduce the incidence of PIP, such as changing the temperature and concentration of propofol ( Jeong and Yoon, 2016 ; Lu et al, 2021 ), controlling injection speed, selecting large vein vessels ( Canbay et al, 2008 ; Desousa, 2016 ), transcutaneous electrical acupoint stimulation ( Jin et al, 2022 ), or pre-treatment or mixed use propofol with drugs, such as lidocaine ( Euasobhon et al, 2016 ; Hong et al, 2016 ; Jeong and Yoon, 2016 ; Sun et al, 2016 ; Zirak et al, 2016 ; Xing et al, 2018 ; Tian et al, 2021 ; Wasinwong et al, 2022 ), nonsteroidal anti-inflammatory drugs ( Madan et al, 2016 ; Miniksar, 2022 ), and dexmedetomidine ( Yu et al, 2015 ; Lu et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%
“…Many techniques have been developed to reduce the incidence of PIP, including changing the temperature and concentration of propofol ( Jeong and Yoon, 2016 ; Lu et al, 2021 ), controlling the injection speed, selecting large vein vessels ( Canbay et al, 2008 ; Desousa, 2016 ), and transcutaneous electrical acupoint stimulation ( Jin et al, 2022 ). The most common techniques are pre-treatment or mixed use of propofol with drugs such as lidocaine ( Euasobhon et al, 2016 ; Hong et al, 2016 ; Jeong and Yoon, 2016 ; Sun et al, 2016 ; Zirak et al, 2016 ; Xing et al, 2018 ; Tian et al, 2021 ; Wasinwong et al, 2022 ), nonsteroidal anti-inflammatory drugs ( Madan et al, 2016 ; Miniksar, 2022 ), dexmedetomidine ( Yu et al, 2015 ; Lu et al, 2021 ), ketamine ( Cheng et al, 2017 ; Akbari et al, 2018 ), nitrous oxide ( Kaabachi et al, 2007 ), opioids ( Kizilcik et al, 2015 ; Lee et al, 2016 ; Singh et al, 2016 ; Lee et al, 2017 ; Wang et al, 2020 ), benzodiazepines ( Guan et al, 2021 ), and magnesium sulfate ( Sun et al, 2016 ). All of these techniques or drugs attenuated PIP to varying degrees, but their drawbacks, such as laryngospasm ( Batra et al, 2005 ; Kaabachi et al, 2007 ), emergence agitation ( Kaabachi et al, 2007 ), gastrointestinal ulcer ( Madan et al, 2016 ), pulmonary embolism ( Davies et al, 2002 ), lengthy onset ( Wang et al, 2020 ), and tinnitus or dizziness ( Xing et al, 2018 ), limited their clinical use, and PIP could not be completely abolished.…”
Section: Introductionmentioning
confidence: 99%