Preemptive enteral nutrition enriched with eicosapentaenoic acid, gamma-linolenic acid and antioxidants in severe multiple trauma: a prospective, randomized, double-blind study

Kagan, Ilya; Cohen, Jonathan; Stein, Michael D.; Bendavid, Itai; Pinsker, Dana; Silva, Veronica; Theilla, Miriam; Anbar, Ronit; Lev, Shaul; Grinev, Milana; Singer, Pierre

doi:10.1007/s00134-015-3646-z

Cited by 40 publications

(34 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Glenn and Wischmeyer [245] analyzed separately the studies administering omega-3 FA as a bolus or in a continuous manner and found that continuous administration improved length of stay and length of ventilation; in contrast, bolus administration had no advantage. The pre-emptive administration of the same formula administered in the first 3 studies in severe, ventilated, multiple trauma patients did not find any advantage [239]. In this study, the membrane content of EPA and DHA was very low at baseline and was hardly corrected with omega-3 and borage oil administration, suggesting that we do not know the exact amount of omega-3 FA to administer to this category of patients.…”

Section: Commentary To Recommendations 30 -32contrasting

confidence: 58%

“…However, even higher doses were not associated with complications. Enteral formulae enriched in borage oil and/or omega-3 FA have been administered in patients suffering from ARDS, acute lung injury (ALI) and sepsis with positive effects regarding length of stay, length of ventilation and even mortality [233,234,239,242]. These four studies used the same study and control formulae.…”

Section: Commentary To Recommendations 30 -32mentioning

confidence: 99%

See 1 more Smart Citation

ESPEN guideline on clinical nutrition in the intensive care unit

et al. 2019

Self Cite

View full text Add to dashboard Cite

s u m m a r yFollowing the new ESPEN Standard Operating Procedures, the previous guidelines to provide best medical nutritional therapy to critically ill patients have been updated. These guidelines define who are the patients at risk, how to assess nutritional status of an ICU patient, how to define the amount of energy to provide, the route to choose and how to adapt according to various clinical conditions. When to start and how to progress in the administration of adequate provision of nutrients is also described. The best determination of amount and nature of carbohydrates, fat and protein are suggested. Special attention is given to glutamine and omega-3 fatty acids. Particular conditions frequently observed in intensive care such as patients with dysphagia, frail patients, multiple trauma patients, abdominal surgery, sepsis, and obesity are discussed to guide the practitioner toward the best evidence based therapy. Monitoring of this nutritional therapy is discussed in a separate document.

show abstract

Section: Commentary To Recommendations 30 -32contrasting

confidence: 58%

Section: Commentary To Recommendations 30 -32mentioning

confidence: 99%

ESPEN guideline on clinical nutrition in the intensive care unit

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Those with low levels at day 6 had significantly more infection, longer ICU, and hospital stay. The same trend was found by Kagan et al [11] after preemptively administrating enteral feeding enriched in omega-3 fatty acids and gamma-linolenic acid in trauma patients. Again no difference was found between the study and the control group but levels of membrane omega-3 index failed to reach therapeutic levels even after 7 days of therapy.…”

Section: Introductionsupporting

confidence: 84%

Focus on nutrition

2016

Self Cite

View full text Add to dashboard Cite

“…Ìè âèä³ëèëè â³ñ³ì äîñë³äaeåíü [233][234][235][236][237][238][239][240], ïðèñâÿ÷åíèõ öüîìó ïèòàííþ; â ÷îòèðüîõ ç íèõ òàêîae çàñòîñîâóâàëèñü àíòèîêñèäàíòè. Ìåòà-àíàë³ç íå âèÿâèâ aeîäíèõ ïåðåâàã (äèâ.…”

Section: êîìåíòàð äî ðåêîìåíäàö³é 30-32unclassified