Preemptive Epidural Analgesia with Bupivacaine and Sufentanyl and the Effects of Epiduraly Added Epinephrine for Thoracic Surgery

Taleska, Gordana; Trajkovska, Trajanka; Kokareva, A; Popovska, A.; Naumoska, Maja; Gavrilovska, Aleksandra; Dzhambazovska-Trajkovska, Vanja; Toleska, Marija; Dimov, Aleksandar

doi:10.3889/mjms.1857-5773.2010.0092

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…In 2 trials, patients underwent a variety of surgical interventions. 47,79 In 4 trials, general anesthesia was systematically administrated in combination with regional anesthesia, 69,72,76,80 and in 5 trials, general anesthesia was used as a rescue in case of failed regional anesthesia. 20,22,25,35,58 Definitions of the end points varied among original studies.…”

Section: Trial Characteristicsmentioning

confidence: 99%

“…Fifteen trials (605 patients) tested epinephrine added to epidural LAs for surgical anesthesia. Regimens were administrated as boluses in 14 trials, 21,23,26,34,38,49,50,53,58,61,65,72,79,81 and via a continuous infusion 76 LAs were bupivacaine (9 trials), lidocaine or ropivacaine (2 each), and chloroprocaine or levobupivacaine (1 each). Concentrations of epinephrine ranged from 2.5 to 5 µg•mL −1 .…”

Section: Labormentioning

confidence: 99%

See 1 more Smart Citation

Benefit and Harm of Adding Epinephrine to a Local Anesthetic for Neuraxial and Locoregional Anesthesia: A Meta-analysis of Randomized Controlled Trials With Trial Sequential Analyses

Tschopp

Tramèr

Schneider

et al. 2018

Anesthesia &Amp; Analgesia

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Section: Trial Characteristicsmentioning

confidence: 99%

Section: Labormentioning

confidence: 99%

Benefit and Harm of Adding Epinephrine to a Local Anesthetic for Neuraxial and Locoregional Anesthesia: A Meta-analysis of Randomized Controlled Trials With Trial Sequential Analyses

Tschopp

Tramèr

Schneider

et al. 2018

Anesthesia &Amp; Analgesia

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Effects of thoracic epidural anesthesia on pulmonary venous admixture and oxygenation with isoflurane or propofol anesthesia during one lung ventilation

Abdel-Rahman

2012

Egyptian Journal of Chest Diseases and Tuberculosis

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Pre-emptive epidural analgesia for acute and chronic post-thoracotomy pain in adults: a systematic review and meta-analysis

Park

Yoon

Kim

et al. 2020

Reg Anesth Pain Med

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Background and objectivesEpidural analgesia is the gold standard for post-thoracotomy pain management and can be started before or after surgical incision. This systematic review and meta-analysis investigated whether pre-emptive epidural analgesia before thoracotomy incision reduces acute and chronic post-thoracotomy pain in adults compared with epidural analgesia after incision.MethodsWe searched databases including MEDLINE, Embase, and CENTRAL for randomized controlled trials comparing epidural analgesia initiated before (pre-emptive group) and after (control group) thoracotomy incision in adults. The primary outcomes were the pain intensity during rest and coughing within 72 hours after surgery and the incidence of pain 1 to 6 months after surgery. Data were combined with random-effects meta-analyses. We rated the quality of evidence as high, moderate, low, and very low using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) method.ResultsWe included 19 trials with 1062 participants involving 529 in the pre-emptive group and 533 in the control group. The pain intensity was significantly lower at rest within 72 hours after surgery (19 studies, n=1062) and during coughing within 48 hours after surgery (11 studies, n=638), and the incidence of pain was significantly lower 1 to 6 months after surgery (6 studies, n=276) in the pre-emptive group than in the control group. The quality of evidence was moderate or low in the primary outcomes.ConclusionsOur review provides low-quality evidence that pre-emptive epidural analgesia reduces the intensity of acute pain and the incidence of chronic pain after thoracotomy in adults.Protocol registration numberCRD42019131620.

show abstract

Preemptive Epidural Analgesia with Bupivacaine and Sufentanyl and the Effects of Epiduraly Added Epinephrine for Thoracic Surgery

Cited by 4 publications

References 28 publications

Benefit and Harm of Adding Epinephrine to a Local Anesthetic for Neuraxial and Locoregional Anesthesia: A Meta-analysis of Randomized Controlled Trials With Trial Sequential Analyses

Benefit and Harm of Adding Epinephrine to a Local Anesthetic for Neuraxial and Locoregional Anesthesia: A Meta-analysis of Randomized Controlled Trials With Trial Sequential Analyses

Effects of thoracic epidural anesthesia on pulmonary venous admixture and oxygenation with isoflurane or propofol anesthesia during one lung ventilation

Pre-emptive epidural analgesia for acute and chronic post-thoracotomy pain in adults: a systematic review and meta-analysis

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