the Heart and Blood in Living Beings," recognized that pulsatile flow through the arterial vessels was coordinated with the contraction of the heart muscle. Harvey described a "double circulation" where ".. . the blood, forced by the action of the left ventricle into the arteries, was distributed to the body at large, and its several parts, in the same manner as it is sent through the lungs, impelled by the right ventricle into the pulmonary artery." 1,2