Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats

Adriani, Walter; Deroche-Gamonet, Véronique; Moal, Michel Le; Laviola, Giovanni; Piazza, Pier Vincenzo

doi:10.1007/s00213-005-0125-1

Cited by 79 publications

(59 citation statements)

References 53 publications

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“…This is not in accord with earlier studies showing reduced neurobehavioral plasticity in adult animals Adriani et al, 2003Adriani et al, , 2006. In these studies, nicotine treatment increased nicotine self-administration in periadolescent rats but not in postadolescent rats, and was associated with increased expression of distinct subunits of acetylcholine receptor in adult rats, downregulation of striatal AMPA receptors in striatum in adult mice, and longterm disruption of locomotor habituation in mice.…”

Section: Discussioncontrasting

confidence: 84%

Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Kemppainen

Hyytiä

Kiianmaa

2009

Alcoholism Clin & Exp Res

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These findings provide no or little support for the views that adolescent animals are more sensitive to the neurobehavioral effects of repeated exposure to nicotine and that exposure to nicotine in adolescence may contribute to enhanced vulnerability to ethanol abuse. Furthermore, genetic predisposition to high or low ethanol self-administration does not seem to be a factor that influences individual vulnerability to the neurobehavioral effects of repeated administration of nicotine.

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Section: Discussioncontrasting

confidence: 84%

Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Kemppainen

Hyytiä

Kiianmaa

2009

Alcoholism Clin & Exp Res

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“…Bracken et al (2011) recently confirmed that adolescent nicotine induces adult nicotine sensitization in the rat. In addition to lasting changes in sensitization, adolescent nicotine leads to enhanced self-administration of nicotine in adult mice (Adriani et al, 2006) and rats ; this, however, was not confirmed by Weaver et al, (2012) in rats.…”

Section: Addiction-related Behavioral Changesmentioning

confidence: 84%

Adolescent nicotine induces persisting changes in development of neural connectivity

Smith

McDonald

Bergstrom

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…Rats that were exposed to caffeine in their drinking water were more likely to acquire the nicotine self-administration response, acquired this behavior more rapidly, and took larger amounts of nicotine than rats that never received caffeine (Shoaib et al, 1999); but, since caffeine exposure was maintained both before and during the acquisition training in this study, it is not known how much these effects were due to a history of caffeine exposure, as opposed to having caffeine in the system at the same time as nicotine. Preexposure to nicotine in post-adolescent rats produced a tolerance-like effect, preventing the development of conditioned place preference when a distinctive environment was associated with 0.3 mg/kg nicotine, but not a higher dose (0.6 mg/kg; Adriani et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

Prior Exposure to THC Increases the Addictive Effects of Nicotine in Rats

Panlilio

Zanettini

Barnes

et al. 2013

Neuropsychopharmacol

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Although it is more common for drug abuse to progress from tobacco to cannabis, in many cases cannabis use develops before tobacco use. Epidemiological evidence indicates that prior cannabis use increases the likelihood of becoming dependent on tobacco. To determine whether this effect might be due to cannabis exposure per se, in addition to any genetic, social, or environmental factors that might contribute, we extended our series of studies on 'gateway drug' effects in animal models of drug abuse. Rats were exposed to THC, the main psychoactive constituent of cannabis, for 3 days (two intraperitoneal injections/day). Then, starting 1 week later, they were allowed to self-administer nicotine intravenously. THC exposure increased the likelihood of acquiring the nicotine selfadministration response from 65% in vehicle-exposed rats to 94% in THC-exposed rats. When the price of nicotine was manipulated by increasing the response requirement, THC-exposed rats maintained higher levels of intake than vehicle-exposed rats, indicating that THC exposure increased the value of nicotine reward. These results contrast sharply with our earlier findings that prior THC exposure did not increase the likelihood of rats acquiring either heroin or cocaine self-administration, nor did it increase the reward value of these drugs. The findings obtained here suggest that a history of cannabis exposure might have lasting effects that increase the risk of becoming addicted to nicotine.

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Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats

Abstract: Exposure following the adolescent period might diminish the risk to develop nicotine dependence. As for human implications, findings are consistent with a reduced vulnerability to nicotine addiction in people who start smoking late in their life.

Cited by 79 publications

References 53 publications

Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Adolescent nicotine induces persisting changes in development of neural connectivity

Prior Exposure to THC Increases the Addictive Effects of Nicotine in Rats

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