Preexposure Prophylaxis for HIV Infection Integrated With Municipal- and Community-Based Sexual Health Services

Liu, Albert Y.; Cohen, Stéphanie; Vittinghoff, Eric; Anderson, Peter L.; Doblecki-Lewis, Susanne; Bacon, Oliver; Chege, Wairimu; Postle, Brian S.; Matheson, Tim; Amico, K. Rivet; Liegler, Teri; Rawlings, M. Keith; Trainor, Nikole; Blue, Robert Wilder; Estrada, Yannine; Coleman, Megan; Cardenas, Gabriel; Feaster, Daniel J.; Grant, Robert M.; Philip, Susan; Elion, Richard; Buchbinder, Susan; Kolber, Michael A.

doi:10.1001/jamainternmed.2015.4683

Cited by 562 publications

(566 citation statements)

References 41 publications

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“…Earlier clinical trials and more recent observational studies of PrEP users reported high STI incidence among participants. [39][40][41][42] Those findings suggest that PrEP is reaching the intended high-risk MSM population. However, it is difficult to extrapolate whether those elevated STI rates were a result of risk compensation following PrEP initiation or from increased detection due to more frequent screening.…”

Section: Existing and Anticipated Challenges Of The Sti Epidemic In Msmmentioning

confidence: 86%

Sexually transmissible infection control programs for men who have sex with men – what will they look like in 2020?

et al. 2017

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Abstract. The resurgence of sexually transmissible infections among men who have sex with men is a concern for sexual health. Traditional strategies have relied on the promotion of condom use, regular testing, treatment, and partner management. Future sexually transmissible infection control programs must combine current prevention methods with novel approaches that target the providers, patients, and mechanisms of health care delivery.

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Section: Existing and Anticipated Challenges Of The Sti Epidemic In Msmmentioning

confidence: 86%

Sexually transmissible infection control programs for men who have sex with men – what will they look like in 2020?

et al. 2017

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“…Early data suggest these non-condombased interventions are associated with reduced condom use and possibly an increase in the number of sexual partners, both of which will increase the reproductive rate of HPV infection and hence the proportion of the population that will need to be vaccinated. 19 Unfortunately, the prospect of widespread and dramatic reductions in HPV incidence and HPV-associated cancers in MSM seem unlikely, with only five countries having adopted universal vaccination of boys before sexual activity. Some countries have adopted programs targeted at sexually active MSM, but with rapid acquisition of infection and reduced vaccine efficacy, it is unlikely that dramatic HPV reductions will occur outside those directly vaccinated.…”

Section: Equity Of Outcome For Msmmentioning

confidence: 99%

Human papillomavirus vaccination in men who have sex with men – what will be required by 2020 for the same dramatic changes seen in heterosexuals

et al. 2017

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Abstract. This paper addresses the issue of whether men who have sex with men (MSM) will share the spectacular reductions in human papillomavirus (HPV) infection and its associated neoplasia that we are currently witnessing in heterosexuals. The reproductive rate for HPV infection in heterosexuals is not well established, but 70% vaccination coverage in women has resulted in a fall of more than 90% in genital warts and HPV types 16/18 in young women and 80% fall in young men indicating that the critical vaccination threshold has been exceeded for this group. Published data on the three elements of the reproductive rate for HPV infection (i.e. transmission probability per sexual partnership, rate of partner change and duration of infectiousness) suggest they are higher in MSM than heterosexuals. This indicates that the reproductive rate for HPV will be higher in MSM and hence the critical vaccination threshold will also be higher. But while vaccinating 70% of girls protect 70% of sexual partnerships in heterosexuals, vaccinating 70% of boys protect more than 70% of partnerships in MSM. Only 9% (30% by 30%) of sexual partnerships in MSM are not protected with 70% coverage. Therefore vaccinating 70% of boys will protect 91% of sexual partnerships in MSM. However the efficacy of the HPV vaccine is much lower when sexually active MSM are vaccinated rather than boys. We argue that if MSM are to have the same benefit from the HPV vaccine that heterosexuals had, boys and not adult MSM will need to be vaccinated.Additional keywords: human papillomavirus vaccine, men who have sex with men.

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“…MSM on PrEP, received a diagnostic HIV test at regular intervals (3 months). MSM who started PrEP were assigned a fixed adherence profile that reflected an average weekly dosage using data from the U.S. PrEP Demo Project [27] weighted by race/ethnicity using methods from Jenness et al 2016 [17], which investigated the impact of the implementation of the U.S. Centers for Disease Control and Prevention's PrEP guidelines on the national HIV epidemic among MSM. For Atlanta, we assigned 21.1% of men as nonadherent (0 doses), 7.0% as taking fewer than 2 doses per week, 10.0% taking 2-3 doses per week, and 61.9% taking ≥4 doses per week; for Seattle, we assigned 14.4% as non-adherent, 4.1% taking <2 doses per week, 5.3% 2-3 doses per week, and 76.2% ≥4 doses per week [17].…”

Section: Hiv Transmission and Progressionmentioning

confidence: 99%

“…The probability of HIV acquisition per sex act was reduced according to the level of adherence. There was little evidence for risk behavior changes among MSM while on PrEP in studies predating the development of this model [27][28][29][30], so we focused on PrEP coverage and adherence and did not model such behavior changes. In order to investigate the possible impacts of HIV self-testing strategies on HIV epidemic dynamics in future models, we added more complex parameters describing clinic-based HIV testing behaviors to the original model to create a new baseline model.…”

Section: Hiv Transmission and Progressionmentioning

confidence: 99%

Development of an Agent-Based Model to Investigate the Impact of HIV Self-Testing Programs on Men Who Have Sex With Men in Atlanta and Seattle (Preprint)

Luo¹,

Katz²,

Hamilton³

et al. 2017

Preprint

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Background: Men who have sex with men (MSM) remain the most heavily impacted group in the US HIV epidemic. Prevention science is increasingly organized around HIV testing as a launch point into an HIV prevention continuum for MSM who are not living with HIV and into an HIV care continuum for MSM who are living with HIV. Increasing HIV testing frequency among MSM might reduce future HIV infections by linking men who are living with HIV to ARV care, resulting in viral suppression. Distributing HIV self-test kits is a strategy to increase HIV testing. Our previous modeling work suggests that the impact of HIV self-tests (HIVST) on transmission dynamics will depend not only on the frequency of the tests and the tester's behavior, but also on epidemiologic and testing characteristics of the population as well.

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Preexposure Prophylaxis for HIV Infection Integrated With Municipal- and Community-Based Sexual Health Services

Cited by 562 publications

References 41 publications

Sexually transmissible infection control programs for men who have sex with men – what will they look like in 2020?

Sexually transmissible infection control programs for men who have sex with men – what will they look like in 2020?

Human papillomavirus vaccination in men who have sex with men – what will be required by 2020 for the same dramatic changes seen in heterosexuals

Development of an Agent-Based Model to Investigate the Impact of HIV Self-Testing Programs on Men Who Have Sex With Men in Atlanta and Seattle (Preprint)

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