Prefabricated nerve conduits advance histomorphological and functional outcomes in nerve regeneration of the sciatic nerve of the rat

Rustemeyer, Jan; Dicke, Ursula

doi:10.1016/j.ijom.2010.05.006

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…CIVD was also observed to be recovered at 3 months post‐autologous nerve grafting, an observation time point at which nerve regeneration and repair outcomes were suitably achieved as indicated by many studies 27, 28. It is thought that a transected nerve can only recover its function partially, especially for motor nerve function,29–32 for example, muscle weight ratio was measured as about 75% and the recovery ratio of CMAP and CNAP amplitudes also about 75% in the current study; however, no significant differences in CIVD and pain sensation were detected between nerve autograft group and normal control at 3 or 6 months after autologous nerve grafting, which deserved further investigation. Additionally, Kusters et al10 reported that sham‐operated rats showed a larger CIVD in the operated paw when compared with the nonoperated one directly after operation; however, in the current study, no significant change in CIVD was observed immediately after sham injury, possibly due to different ways of cold stress disposition and different CIVD quantification approaches.…”

Section: Discussionsupporting

confidence: 44%

Laser doppler perfusion imaging of skin territory to reflect autonomic functional recovery following sciatic nerve autografting repair in rats

Yang

Chang

et al. 2012

Microsurgery

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Peripheral nerve repair requires comprehensive evaluation of functional outcomes of nerve regeneration; however, autonomic nerve function is seldom evaluated probably due to lack of suitable quantitative methods. This study sought to determine whether autonomic functional recovery could be reflected by cold-induced vasodilation (CIVD) within target skin territory, as monitored by laser Doppler perfusion imaging (LDPI). Rats with sciatic nerve defect injury received autologous nerve grafting, and the plantar surface of the hind feet was subjected to LDPI analysis following nerve repair. The results indicated that at 3 and 6 months after autologous nerve grafting, the plantar surface of the hind foot exhibited the same level of CIVD as contralateral normal side, whereas rats in nerve defect group (negative control) showed significantly reduced CIVD. In addition, suitable nerve regeneration and functional recovery were achieved as assessed by pain sensation tests as well as electrophysiological and immunohistological examinations. Based on the potential influence of local autonomic nerve signals on CIVD, it was possible to evaluate functional recovery of autonomic nerves by using LDPI measurements of dermal CIVD.

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Section: Discussionsupporting

confidence: 44%

Laser doppler perfusion imaging of skin territory to reflect autonomic functional recovery following sciatic nerve autografting repair in rats

Yang

Chang

et al. 2012

Microsurgery

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“…These research data inspired us to use this method to substitute traditional epineurial neurorrhaphy for repairing peripheral nerve injury. Although many researchers had reported the good functional recovery after applying conduit to repair the nerve defect,9-11 we designed this method to repair peripheral nerve injury, not for nerve defect. After getting the Chinese Government SFDA permission and Peking University People's Hospital Ethics Committee, we applied biological conduit small gap (2mm) tubulization in human intending to confirm the possibility and feasibility of substituting traditional epineurial neurorrhaphy for repairing peripheral nerve injury.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable Conduit Small Gap Tubulization for Peripheral Nerve Mutilation: A Substitute for Traditional Epineurial Neurorrhaphy

Zhang¹,

Han²,

Wang³

et al. 2013

Int. J. Med. Sci.

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Nerve regeneration and re-innervation are usually difficult after peripheral nerve injury. Epineurium neurorrhaphy to recover the nerve continuity is the traditional choice of peripheral nerve mutilation without nerve defects, whereas the functional recovery remains quite unsatisfactory. Based on previous research in SD rats and Rhesus Monkeys, a multiple centers clinical trial about biodegradable conduit small gap tubulization for peripheral nerve mutilation to substitute traditional epineurial neurorrhaphy was carried out. Herein, the authors reviewed the literature that focused on peripheral nerve injury and possible clinical application, and confirmed the clinical possibilities of biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation. The biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation may be a revolutionary innovation in peripheral nerve injury and repair field.

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Morphofunctional Effect of Stem Cells on the Regeneration of the Facial Nerve in a Rat Model

Raimundo

Landim

Gomes

et al. 2019

Journal of Oral and Maxillofacial Surgery

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Prefabricated nerve conduits advance histomorphological and functional outcomes in nerve regeneration of the sciatic nerve of the rat

Cited by 4 publications

References 44 publications

Laser doppler perfusion imaging of skin territory to reflect autonomic functional recovery following sciatic nerve autografting repair in rats

Laser doppler perfusion imaging of skin territory to reflect autonomic functional recovery following sciatic nerve autografting repair in rats

Biodegradable Conduit Small Gap Tubulization for Peripheral Nerve Mutilation: A Substitute for Traditional Epineurial Neurorrhaphy

Morphofunctional Effect of Stem Cells on the Regeneration of the Facial Nerve in a Rat Model

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