Prefabrication of a High-Density Porous Polyethylene Implant Using a Vascular Induction Technique

Can, Zeki; Apaydin, I; Ar, Erçöçen; Me, Demirseren; Sabuncuoğlu, Bizden

doi:10.1097/00000637-199809000-00007

Cited by 15 publications

(10 citation statements)

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“…For this reason, the use of alloplastic materials that can be shaped in detail 3-dimensionally and that are safer because they do not show resorption or deformation is becoming more popular. Porous materials, like polytetrafluoroethylene, are invaded by a fibroneovascular tissue and become a single unit with vascular bed and tissues after they are implanted [14,15]. This situation makes them resistant to infection and movement.…”

Section: Discussionmentioning

confidence: 99%

Flap prefabrication using high-density porous polyethylene in an animal model – an experimental study

Krakowczyk

Maciejewski

Szymczyk

et al. 2013

Med Sci Monit Basic Res

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BackgroundThe search for new surgical flap techniques and modifications of already existing ones is gaining increasing popularity. Progress in flap designing and harvesting have improved the functional and aesthetic results, especially in head and neck reconstruction.Material/MethodsTen pigs were used in this study. In the first operation, high-density porous polyethylene prefabrication was performed bilaterally in all pigs. After 8 weeks, each prefabricated complex was explored, resected, and macroscopically evaluated.ResultsAll of 20 prefabricated flaps survived. No serious surgical complications were observed. In 2 cases there was chronic inflammation and in 4 cases there was instability of the implant.ConclusionsAfter this experimental study, we believe that the use of high-density porous polyethylene in flap prefabrication may be a good option for reconstruction of 3-dimensional defects, especially in patients with limited donor tissues.

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Section: Discussionmentioning

confidence: 99%

Flap prefabrication using high-density porous polyethylene in an animal model – an experimental study

Krakowczyk

Maciejewski

Szymczyk

et al. 2013

Med Sci Monit Basic Res

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“…Most reports published worldwide on problems associated with the prefabrication of artificial microvascular complexes describe experiences with using double-component pedicled flaps prefabricated on small laboratory animals (rats, rabbits) [8, 10, 11]. They have proven beyond doubt that the process of neovascularization carries the possibility of designing simple connections between blood vessels and tissues.…”

Section: Discussionmentioning

confidence: 99%

The use of prefabication technique in microvascular reconstructive surgery

Krakowczyk¹,

Maciejewski²,

Szymczyk³

et al. 2012

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Aim of the studyThe aim of the study was to develop standards for the prefabrication of free microvascular flaps in an animal model, followed by their application in clinical practice, and quantitative/qualitative microscopic assessment of the extent of development of a new microvascular network.Material and methodsThe study was carried out in 10 experimental pigs. As the first stage, a total of 20 prefabricated flaps were created using polytetrafluoroethylene (PTFE) as a support material, placed horizontally over an isolated and distally closed vascular pedicle based on superficial abdominal vessels. After completing the animal model study, one patient was selected for the grafting of the prefabricated free flap.ResultsAll 20 free flaps prefabricated in the animal model were analyzed microscopically, exhibiting connective tissue rich in fibroblasts and small blood vessels in the porous areas across the entire thickness of the PTFE element.ConclusionsFlap prefabrication is a new and fast developing reconstruction technique. The usefulness of prefabrication techniques and their status in reconstructive surgery still needs to be investigated experimentally and clinically. The method based on prefabricated free flaps is the first step towards anatomical bioengineering that will make it possible to replace missing organs with their anatomically perfect equivalents.

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“…17 Recent experimental studies have been published regarding bone flap prefabrication using allogenic implants and demineralized allogenic bone. 28,29 In these studies both the artery and vein have been used as a vascular pedicle. The problem with these studies is the sacrifice of an artery for prefabrication.…”

Section: Discussionmentioning

confidence: 99%

Bone Flap Prefabrication

Top¹,

Aygıt²,

Sarıkaya³

et al. 2005

Annals of Plastic Surgery

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The usual method to prefabricate a bone flap is to harvest a nonvascularized bone graft and to implant the artery and vein bundle between segments of bone graft. The basic problem of this method is sacrificing an artery for prefabrication. Another method for creating flap donor sites without using an artery is venous flap prefabrication. There are a few articles describing bone flap prefabrication, and these include implantation of both artery and vein as a vascular bundle. Also, there is no experimental study in the literature using a vein or an arterialized vein pedicle for bone flap prefabrication. As an experimental model for bone flap prefabrication, the rabbit ear vascular model was chosen. For the experiments 3 groups were formed. Each group contained 5 rabbits. In the first experimental group a vein was implanted between the halves of bone graft. In the second experimental group an arterialized vein was implanted between the halves of bone graft. To compare the viability of the bone graft of the 2 prefabrication groups, a bone graft was implanted into the subcutaneous pocket of the posterior auricular area in the third group. The authors examined 5 rabbits in each group by microangiography at the end of 6 weeks except for group 3. On microangiographic analysis, groups 1 and 2 showed patency of the vascular pedicle. There was no difference between these 2 groups from the point of view of vascular patency and bone appearance. Bone scintigraphy was performed for 5 rabbits in each group. On bone scintigraphic scans, the bone component of the flaps was visualized in groups 1 and 2, but not in group 3. A quantitative analysis of images was performed by drawing symmetric spherical regions of interest (ROIs) over both the implanted area and cranial bone. The uptake ratios were computed by dividing the mean counts in the implanted ROI by mean counts in the cranial bone ROI. The mean value was 0.86 +/- 0.02 in group 1 and 0.86 +/- 0.04 in group 2. A statistically significant uptake difference was not seen between venous and arterialized venous groups (P < 0.01). Histologic examination was performed all rabbits in each group, and demonstrated that the bony component was viable, showing osteocytes containing lacunae, osteoblasts along bony trabeculae, and vascular channels in groups 1 and 2. In group 3, the bony architecture of the graft was still apparent, but all bone within it was dead. There were no significant microangiographic, histologic, and scintigraphic differences between the 2 experimental methods.

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Prefabrication of a High-Density Porous Polyethylene Implant Using a Vascular Induction Technique

Cited by 15 publications

References 0 publications

Flap prefabrication using high-density porous polyethylene in an animal model – an experimental study

Flap prefabrication using high-density porous polyethylene in an animal model – an experimental study

The use of prefabication technique in microvascular reconstructive surgery

Bone Flap Prefabrication

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