Preface

Lewis, Agnes Smith; Gibson, Margaret Dunlop

doi:10.1017/cbo9781139169196.003

Cited by 1 publication

(2 citation statements)

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“…Nevertheless, the relative differences between the Adh genotypes in oxidation of propan-2-01 are somewhat greater than in ethanol elimination. This was found earlier in vitro (DAY, HILLIER and CLARKE 1974;LEWIS and GIBSON 1978;WINBERG, HOVIK and MCKINLEY-MCKEE 1985). The differences in elimination rates of ethanol between genotypes are found to be smaller than between their total ADH activities measured in vitro (DAY, HILLIER and CLARKE 1974;EISSES et al 1985a;EISSES 1986).…”

Section: Discussionsupporting

confidence: 71%

“…Previous studies have shown differences between their alcohol dehydrogenase allozymes (ADH, EC 1.1.1.1 .) with respect to in vivo quantity, total ADH activity in vitro, thermostability and kinetic-catalytic properties, respectively (THORIG, SCHOONE and SCHARLOO 1975;LEWIS and GIBSON 1978;MCDONALD, ANDERSON and SANTOS 1980;WINBERC, THATCHER and MCKINLEY-MCKEE 1982a,b;HOVIK, WINBERC and MCKINLEY-MCKEE 1984;EISSES et al 1985a;HEINSTRA et al 1986b). A major part of the difference in ADH quantity between AdhFiF and Adhsis flies can be explained by regulation of transcriptional activity (ANDERSON and MCDONALD 1983).…”

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confidence: 99%

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Physiological Significance of the Alcohol Dehydrogenase Polymorphism in Larvae of Drosophila

1987

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This study deals with biochemical and metabolic-physiological aspects of the relationship between variation in in vivo alcohol dehydrogenase activity and fitness in larvae homozygous for the alleles Adh71k, AdhF, AdhS, of Drosophila melanogaster, and for the common Adh allele of Drosophila simulans. The Adh genotypes differ in the maximum oxidation rates of propan-2-ol into acetone in vivo. There are smaller differences between the Adh genotypes in rates of ethanol elimination. Rates of accumulation of ethanol in vivo are negatively associated with larval-to-adult survival of the Adh genotypes. The rank order of the maximum rates of the ADHs in elimination of propan-2-ol, as well as ethanol, is ADH-71k > ADH-F > ADH-S- > simulans-ADH. The ratio of this maximum rate to ADH quantity reveals the rank order of ADH-S > ADH-F > ADH-71k > simulans-ADH, suggesting a compensation for allozymic efficiency by the ADH quantity in D. melanogaster.—Our findings show that natural selection may act on the Adh polymorphism in larvae via differences in rates of alcohol metabolism.

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Section: Discussionsupporting

confidence: 71%

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confidence: 99%