Preface

Foster, Henry L.; Small, J. David; Fox, James G.

doi:10.1016/b978-0-12-262503-9.50006-2

Cited by 9 publications

(8 citation statements)

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“…Experiments were conducted using the mouse model described by Song et al [ 31 ]. Male Swiss Webster mice weighing 25-35 g were anesthetized with 5% isoflurane/oxygen (EZ Systems, Palmer, PA) and 40% of their calculated blood volume [ 32 ] removed by cardiac puncture over a period of 1 minute using a 26 gauge needle and 1.0 ml syringe essentially as previously described [ 33 ]. Sham animals were anesthetized and the needle inserted into the heart but no blood was withdrawn.…”

Section: Methodsmentioning

confidence: 99%

17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

et al. 2011

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BackgroundHemorrhage increases inducible nitric oxide synthase (iNOS) and depletes ATP levels in various tissues. Previous studies have shown that geldanamycin, an inducer of heat shock protein 70kDa (HSP-70) and inhibitor of iNOS, limits both processes. Reduction in NO production limits lipid peroxidation, apoptosome formation, and caspase-3 activation, thereby increasing cellular survival and reducing the sequelae of hemorrhage. The poor solubility of geldanamycin in aqueous solutions, however, limits its effectiveness as a drug. 17-DMAG is a water-soluble analog of geldanamycin that might have greater therapeutic utility. This study investigated the effectiveness of 17-DMAG at reducing hemorrhagic injury in mouse small intestine.ResultsIn mice, the hemorrhage-induced iNOS increase correlated with increases in Kruppel-like factor 6 (KLF6) and NF-kB and a decrease in KLF4. As a result, increases in NO production and lipid peroxidation occurred. Moreover, hemorrhage also resulted in decreased Bcl-2 and increased TNF-α, IL-6, and IL-10 concentrations, p53 protein, caspase-3 activation, and cellular ATP depletion. A shortening and widening of villi in the small intestine was also observed. Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and TNF-α and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration. 17-DMAG treatment by itself upregulated HSP-70, Bcl-2, and p53.ConclusionSince 17-DMAG is water soluble, bioactive, and not toxic, 17-DMAG may prove useful as a prophylactic drug for hemorrhage.

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Section: Methodsmentioning

confidence: 99%

17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

et al. 2011

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“…The Po half-time estimates for these organs are admittedly only approximations, as only six points are available for the regression analysis and the first measurement was not made until 30 days post exposure. Additional error is introduced by assuming single exponential kinetics for the two .organs in the absence of data prior to day 30 and by using average testis and kidney weights for mice (Ivanyi et al 1972;Foster et al 1983) to estimate total organ Po content. Nevertheless, the retention curves fit to these data do qualitatively suggest that the radiological dose imparted from the Po to the testes might only be a factor of 2-4 less than the kidney dose.…”

Section: Retentionmentioning

confidence: 99%

Primate polonium metabolic models and their use in estimation of systemic radiation doses from bioassay data. Final report

Cohen¹

1989

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“…This is not a comprehensive review; research on wild house mice encompasses a diverse range of topics, only some of which are touched on here. For more information, we refer readers to ‘ The mouse in biomedical research ’ ( Foster et al, 1981 ; Fox et al, 2007 ), ‘ The genus Mus as a model for evolutionary studies ’ ( Britton-Davidian and Searle, 2005 ) and ‘ Evolution of the house mouse ’ ( Macholán et al, 2012 ).…”

Section: Insights From Wild House Micementioning

confidence: 99%

Insights into mammalian biology from the wild house mouse Mus musculus

Phifer‐Rixey

Nachman

2015

eLife

169

127

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The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.DOI: http://dx.doi.org/10.7554/eLife.05959.001

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Preface

Cited by 9 publications

References 0 publications

17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

Primate polonium metabolic models and their use in estimation of systemic radiation doses from bioassay data. Final report

Insights into mammalian biology from the wild house mouse Mus musculus

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