Objective-To determine effectiveness and adverse effects of anticonvulsant drugs in management ofpain.Design-Systematic review of randomised controlled trials ofanticonvulsants for acute, chronic, or cancer pain identified by using Medline, by hand searching, by searching reference lists, and by contacting investigators.Subjects-Between 1966 and February 1994, 37 reports were found; 20 reports, of four anticonvulsants, were eligible.Main outcome measures-Numbers needed to treat were calculated for effectiveness, adverse effects, and drug related withdrawal from study.