Preface to the special issue, ‘Embryonic and adult neurogenesis in vertebrate’

Nakamura, Harukazu

doi:10.1111/dgd.12304

Cited by 1 publication

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References 9 publications

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“…The relationship between the development of CNS disorders and the presence of hyper-and hypo pigmentary lesions on the skin of the pediatric patient has been known since the earliest descriptions of syndromes involving the CNS [1,2]. Its importance lies not only in its clinical relevance, but also in the fact that the neurophysiological bases of this relationship remain the key to the understanding of neuro developmental pathological processes, especially those that manifest in the pediatric age [3]. Within the cutaneous macules that appear as dyschromia, the hyper pigmented ones, especially the so-called café au lait spots (CALS) are the most recognizable by their tone and shape and their less variability with respect to other types of dyschromia.…”

Section: Introductionmentioning

confidence: 99%

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

Carratalá-Marco¹

2017

OAJNN

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Introduction:The Café au lait spots (CALS) are shown in the normal population without pathological significance, although they could also be criteria for some neurologic syndromes. Unspecific association with general neurologic illnesses has been less frequently described. We want to know in which measure, the presence of isolated CALS represents a risk factor for neurological disease. Patients and methods:We set up an observational transversal study of cases, patients admitted for neuropaediatric reasons (NPP; n=49) excluding all the patients suffering from neurologic illnesses associated to CALS, and controls, a hospital simultaneously admitted pediatric population for non-neurologic causes (CP; n=101) since October 2012 to January 2013. The data were collected from the clinical reports at admission, and then analyzed by SPSS 22.0 statistical package, and the Stat Calc module of EpiInfo 7.0, following the ethics current rules of the institution for observational studies.Results: Twelve out of 49 NPP (24.4%) showed at least one CALS, while only 10 out of 101 PC (9.9%) (OR= 4.38; IC=1.03-19.74) did it, being the probability of showing CALS at least 4 times significantly higher in the NPP group than in the CP group. The epileptic patients (Χ2=14.19; p=0.0002) and those admitted for encephalopathy studies (Χ2=45.7; p=0.000000) showed a significantly higher prevalence of de CALS. Conclusion:The prevalence of CALS was significantly higher among the patients admitted because of neurologic problems excluding syndromes or illnesses associated to them.

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Section: Introductionmentioning

confidence: 99%

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

Carratalá-Marco¹

2017

OAJNN

View full text Add to dashboard Cite

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Preface to the special issue, ‘Embryonic and adult neurogenesis in vertebrate’

Cited by 1 publication

References 9 publications

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

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