Preface

Colloca, Luana

doi:10.1016/s0074-7742(18)30087-4

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…We will neither present nor discuss the vast body of evidence with regard to neurobiology and neurochemistry of the placebo response, but again refer to the literature, e.g., Fabrizio Benedetti´s book (33), and Luana Colloca´s reader (34, 35).…”

Section: Historical Rootsmentioning

confidence: 99%

Placebo Effects in Psychotherapy: A Framework

Enck¹,

Zipfel²

2019

Front. Psychiatry

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The issue of placebo response and the extent of its effect on psychotherapy is complex for two specific reasons: i) Current standards for drug trials, e.g., true placebo interventions, double-blinding, cannot be applied to most psychotherapy techniques, and ii) some of the “nonspecific effects” in drug therapy have very specific effects in psychotherapy, such as the frequency and intensity of patient–therapist interaction. In addition, different psychotherapy approaches share many such specific effects (the “dodo bird verdict”) and lack specificity with respect to therapy outcome. Here, we discuss the placebo effect in psychotherapy under four aspects: a) nonspecific factors shared with drug therapy (context factors); b) nonspecific factors shared among all psychotherapy traditions (common factors); c) specific placebo-controlled options with different psychotherapy modalities; and d) nonspecific control options for the specific placebo effect in psychotherapy. The resulting framework proposes that the exploration and enumeration of context factors, common factors, and specific factors contributes to the placebo effects in psychotherapy.

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Section: Historical Rootsmentioning

confidence: 99%

Placebo Effects in Psychotherapy: A Framework

Enck¹,

Zipfel²

2019

Front. Psychiatry

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“…To understand how placebo and nocebo science may be applied to address the current dual pain and opioid crises, we first review several elemental principles and relevant key research findings. Beginning with nomenclature, placebo and nocebo effects are psychoneurobiological responses that occur in the body as result of positive and negative expectations (Colloca, 2018a, 2018b; Wager & Atlas, 2015). Expectations result in brain events that trigger the release of endogenous neuropeptides and influence behaviors.…”

Section: Introductionmentioning

confidence: 99%

Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit

Darnall

Colloca

2018

International Review of Neurobiology

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Pain, a noxious psychosensory experience, motivates escape behavior to assure protection and survival. Psychological factors alter the experience and trajectory of pain, as well as behavior and treatment response. In the context of pain, the placebo effect (expectation for pain relief) releases endogenous opioids and facilitates analgesia from exogenously administered opioids. Nocebo hyperalgesia (expectation for persistent or worsening pain) opposes endogenous opioid analgesia and patient engagement in prescription opioid tapering. Reductions in nocebo hyperalgesia and pain catastrophizing may enhance descending modulation of pain, mediate adaptive structural brain changes and promote patient engagement in opioid tapering. Interventions that minimize nocebo and optimize placebo may adaptively shape the central nervous system toward pain relief and potentially opioid reduction. Here we provide a critical description of catastrophizing and its impact on pain, placebo and nocebo effects. We also consider the importance of minimizing nocebo and optimizing placebo effects during prescription opioid tapering, and offer a clinical toolkit of resources to accomplish these goals clinically.

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Harnessing the power of placebos and mitigating nocebo effects in clinical practice

Wettergreen

Plauche

Stewart

2022

J Am Coll Clin Pharm

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Placebo and nocebo effects refer to the true or perceived benefits or harms, respectively, from either an inert or pharmacologically active substance. Both placebo and nocebo effects are often an unseen factor in the care of patients, yet remain controversial and underrecognized. As one of the most readily accessible health professionals, pharmacists are afforded myriad opportunities to address placebo and nocebo effects in their clinical practice settings. The balance between beliefs (positive effects) and fears (negative effects) is one that pharmacists can become adept at navigating through practical strategies provided for individuals, health‐systems, the pharmacy profession, and the overall healthcare community. Future research endeavors should focus on efficacy of previously discussed strategies when utilized by pharmacists, such as patient education strategies.

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Preface

Cited by 6 publications

References 35 publications

Placebo Effects in Psychotherapy: A Framework

Placebo Effects in Psychotherapy: A Framework

Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit

Harnessing the power of placebos and mitigating nocebo effects in clinical practice

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