Purpose-To improve understanding of the etiologic relation between type 2 diabetes and urinary incontinence (UI), we examined associations between diabetes and UI type, among 71,650 women aged 37 to 79 years in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II). We pooled data from the two cohorts, and estimated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression, adjusting for age, parity, body mass index, smoking, hysterectomy, functional limitations, menopausal status, postmenopausal hormone use, incontinence-promoting medications, and study cohort.
Materials and Methods-FromResults-The incidence of at least weekly UI was 5.3% (3,612/67,984) among women without type 2 diabetes and 8.7% (318/3,666) among women with diabetes. Overall, the multivariableadjusted odds of incident UI were increased 20% (OR 1.2, 95% CI 1.0-1.3, p=0.01) among women with versus without type 2 diabetes. This increase appeared largely explained by significantly greater odds of urge UI (OR 1.4, 95% CI 1.0-1.9, p=0.03); there was no apparent association between diabetes and either stress (p=0.3) or mixed (p=0.6) UI, although confidence intervals were somewhat wide.Conclusions-Our findings suggest that type 2 diabetes may especially influence urge UI. Further research is needed to confirm this finding and identify pathways linking these conditions.