Preference for cocaine by the weight pulling method in rats

Suzuki, Tsutomu; Masukawa, Yoshikazu; Yoshii, Toshitaka; Kawai, Teiko; Yanaura, Saiζo

doi:10.1016/0091-3057(90)90272-j

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…Points were derived by dividing the mean number of cocaine deliveries at each dose and FR value by the mean number of cocaine deliveries at the appropriate cocaine concentration at FR 8. Bell, & Lemaire, 1993;Meisch, George, & Lemaire, 1990) and are consistent with reports that cocaine will function as an orally delivered reinforcer in rodents (George, Elmer, Meisch, & Goldberg, 1991;Suzuki, Masukawa, Yoshii, Kawai, & Yanaura, 1990). These data also show that behavior maintained by orally delivered cocaine can be similar to that maintained by other admin-istration routes (e.g., Goldberg, Morse, & Goldberg, 1976;Pickens & Thompson, 1968).…”

Section: Oral Cocaine As a Reinforcersupporting

confidence: 88%

Ratio Size and Cocaine Concentration Effects on Oral Cocaine‐reinforced Behavior

Macenski

Meisch

1998

J Exper Analysis Behavior

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Monkeys were given a choice between cocaine solutions and water under concurrent fixed-ratio reinforcement schedules. The operant response was spout contact. Six rhesus monkeys served as subjects. The cocaine concentration was varied from 0.0125 to 0.8 mg/ml, and the fixed-ratio value was varied from 8 to 128. Cocaine maintained higher response rates than did water over a wide range of conditions. Response rate and number of cocaine deliveries per session were inverted U-shaped functions of concentration. These functions were shifted to the right as the fixed ratio was increased. The number of cocaine deliveries was more persistent as fixed-ratio value was increased when the unit dose was larger rather than smaller. Cocaine consumption was analyzed as a function of unit price (fixed-ratio value divided by cocaine concentration), and unit price accounted for between 77% and 92% of the variance in cocaine consumption for individual monkeys. The current data support the claim that a drug's reinforcing effects increase directly with dose and underscore the need to gather parametric data when examining the effects of experimental manipulations on a drug-reinforced baseline.

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Section: Oral Cocaine As a Reinforcersupporting

confidence: 88%

Ratio Size and Cocaine Concentration Effects on Oral Cocaine‐reinforced Behavior

Macenski

Meisch

1998

J Exper Analysis Behavior

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“…Nevertheless, ingested cocaine has been found to be behaviorally active in rats in that it functions as a positive reinforcer (Falk, Vigorito, Tang, & Lau, 1990;Jentsch, Henry, Mason, Merritt, & Ziriax, 1998;Meert & Janssen, 1992;Seidman. Lau, Chen, & Falk, 1992;Suzuki, Masukawa, Yoshii, Kawai, & Yanaura, 1990; for an exception, see Bell, Macenski, Silverman, & Meisch, 1993), increases locomotor activity Lau, Iman, Ma, & Falk, 1991), and induces indications of a withdrawal syndrome during forced abstinence (Barros & Miczek, 1996). Specifically, Jentsch et al (1998) trained rats to respond for small aliquots of a cocaine-saccharin solution following home-cage preexposure to the solution.…”

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confidence: 99%

Oral cocaine seeking by rats: Action or habit?

Miles¹,

Everitt²,

Dickinson³

2003

Behavioral Neuroscience

171

149

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Having established that the presence of cocaine in a 10% (wt/vol) sucrose solution enhanced the reinforcing properties of the solution in a dose-dependent manner, the authors investigated the susceptibility of oral cocaine seeking to outcome devaluation. Rats were trained to perform different instrumental responses for a cocaine-sucrose and a lemon-sucrose solution. An aversion was then conditioned from either the cocaine-sucrose or the lemon-sucrose solution by pairing consumption with lithium chloride. When instrumental performance was subsequently tested in extinction, the rats performed the lemon-sucrose response less if this solution, rather than cocaine-sucrose, had been devalued by aversion conditioning. By contrast, performance of the cocaine-sucrose response was unaffected by whether the cocaine-sucrose or the lemon-sucrose solution had been devalued.

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“…Orally self-administered cocaine can result in a conditioned place preference in rats (Seidman, Lau, Chen, & Falk, 1992). After a history of eating cocaine-admixed food, rats showed a preference for the drug-admixed food (Suzuki, Masukawa, Yoshii, Kawai, & Yanaura, 1990); this preference persisted despite response effort increases (i.e., increased weight pulling). Cocaine serves as an orally delivered reinforcer for C57BL/6J mice (George, Elmer, Meisch, & Goldberg, 1991).…”

mentioning

confidence: 99%

“…Two factors have been identified as important in establishing cocaine as an orally delivered reinforcer. The first is inducing substantial cocaine ingestion (Falk & Lau, 1993; Meisch et al, 1993; Suzuki et al, 1990). The second is placing cocaine in a readily consumed ethanol solution (Falk & Lau, 1993; Meisch et al, 1990) or in food (Suzuki et al, 1990).…”

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confidence: 99%

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Oral cocaine self-administration in rhesus monkeys: Strategies for engendering reinforcing effects.

Macenski¹,

Meisch²

1995

Experimental and Clinical Psychopharmacology

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Orally delivered cocaine was established as a reinforcer for 8 rhesus monkeys (Macaco mulatto). Initially, each monkey was given a choice between the water vehicle and a 0.2 mg/ml cocaine concentration. The 0.2 mg/ml solution was not consumed in preference to water. One or more acquisition procedures were used with each monkey to establish orally delivered cocaine as a reinforcer. A common feature of all but one procedure was environmental situations that lead to the elective drinking of the cocaine solution. Evidence confirming the establishment of cocaine's reinforcing effects was obtained by testing each monkey across a broad range of cocaine concentrations under conditions of concurrent access to the cocaine solution and vehicle. Over a range of concentrations, the monkeys obtained greater cocaine than vehicle deliveries.

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Preference for cocaine by the weight pulling method in rats

Cited by 9 publications

References 15 publications

Ratio Size and Cocaine Concentration Effects on Oral Cocaine‐reinforced Behavior

Ratio Size and Cocaine Concentration Effects on Oral Cocaine‐reinforced Behavior

Oral cocaine seeking by rats: Action or habit?

Oral cocaine self-administration in rhesus monkeys: Strategies for engendering reinforcing effects.

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