Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Objective: This study investigates the gut microbiome of Indians residing in India, Indian immigrants in Canada, and Canadians of Indian ancestry to understand the impact of westernization on their gut. Given the higher risk of Inflammatory Bowel Disease (IBD) among Indo-Canadians, these results provide insight into how westernization of the gut microbiome may influence incidence of IBD. Design: Stool samples were collected from healthy Indians in India, Immigrants born in India, Indo-Canadians, plus Canadian-borne individuals with European descent and Euro-Immigrants as non-Indian/westernized controls (N = 174).16S and shotgun sequencing compared microbial taxa and functional profiles across groups. Dietary and demographic data were collected to assess lifestyle patterns. Results: The microbiome of Indians and Indo-Immigrants were found to be distinct from westernized groups, with high abundances of Prevotella spp. and CAZymes known to facilitate the breakdown of plant-based foods, reflecting their traditional high complex carbohydrate diet. The Indian microbiome also showed characteristics of high bacterial cell turnover, pathogenic potential and stress tolerance, indicating their gut may be better primed to handle stressors on the gut. Indo-Canadians exhibited a transitional gut microbiome, harbouring taxa both common to Indians and westernized groups, which followed a pattern of increasing dietary acculturation. Conclusions: The transition from a non-westernized to westernized microbiome in Canadian-borne Indian migrants highlights the significant influence that the westernized lifestyle and dietary acculturation has on the gut microbiome. Considering globalization and immigration to westernized countries is occurring at a rapid rate, with 40.6% of the Canadian population made up of first- and second-generation immigrants,1 future research should investigate the health implications that such microbiome transitions have on immigrant populations and newly industrialized nations.
Objective: This study investigates the gut microbiome of Indians residing in India, Indian immigrants in Canada, and Canadians of Indian ancestry to understand the impact of westernization on their gut. Given the higher risk of Inflammatory Bowel Disease (IBD) among Indo-Canadians, these results provide insight into how westernization of the gut microbiome may influence incidence of IBD. Design: Stool samples were collected from healthy Indians in India, Immigrants born in India, Indo-Canadians, plus Canadian-borne individuals with European descent and Euro-Immigrants as non-Indian/westernized controls (N = 174).16S and shotgun sequencing compared microbial taxa and functional profiles across groups. Dietary and demographic data were collected to assess lifestyle patterns. Results: The microbiome of Indians and Indo-Immigrants were found to be distinct from westernized groups, with high abundances of Prevotella spp. and CAZymes known to facilitate the breakdown of plant-based foods, reflecting their traditional high complex carbohydrate diet. The Indian microbiome also showed characteristics of high bacterial cell turnover, pathogenic potential and stress tolerance, indicating their gut may be better primed to handle stressors on the gut. Indo-Canadians exhibited a transitional gut microbiome, harbouring taxa both common to Indians and westernized groups, which followed a pattern of increasing dietary acculturation. Conclusions: The transition from a non-westernized to westernized microbiome in Canadian-borne Indian migrants highlights the significant influence that the westernized lifestyle and dietary acculturation has on the gut microbiome. Considering globalization and immigration to westernized countries is occurring at a rapid rate, with 40.6% of the Canadian population made up of first- and second-generation immigrants,1 future research should investigate the health implications that such microbiome transitions have on immigrant populations and newly industrialized nations.
Background: Indian immigration to westernized countries has surged in recent years, with this demographic facing a higher risk of Inflammatory Bowel Disease (IBD) after migration. Studying the gut microbiome is crucial to understanding the factors contributing to IBD, yet Indians remain underrepresented in microbiome research, Objective: This study investigates the gut microbiome of Indians residing in India, Indian immigrants in Canada, and Canadians of Indian ancestry to understand the impact of westernization on their gut. Given the higher risk of IBD among Indo-Canadians, these results provide insight into how westernization of the gut microbiome may influence incidence of IBD. Stool samples were collected from healthy Indians in India, Indian Immigrants in Canada, Indo-Canadians, plus Canadian-borne individuals with European descent and Euro-Immigrants as non-Indian/westernized controls (N = 174). 16S rRNA gene and shotgun sequencing compared microbial taxa and functional profiles across groups. Dietary and demographic data were collected to assess lifestyle patterns. Results: Indians and Indo-Immigrants had distinct gut microbiotas from westernized groups, with high abundances of Prevotella spp. and a CAZyme profile reflecting their traditional high complex carbohydrate diet. The Indian microbiome also showed characteristics of high bacterial cell turnover, pathogenic potential, and stress tolerance, indicating their gut may be better primed to handle stressors on the gut. Indo-Canadians displayed a transitional microbiome towards westernization, which followed a pattern of increasing dietary acculturation. Conclusions: The shift from a non-westernized to westernized microbiome in Indo-Canadians highlights the significant influence that westernization and dietary acculturation has on the gut microbiome. Given that 44% of the Canadian population is made up of first- and second-generation immigrants and westernized practices are being adopted worldwide, future research should investigate the health implications that such microbiome transitions have on immigrant populations and newly industrialized nations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.