Preferences for herpes zoster vaccination among adults aged 50 years and older in the United States: results from a discrete choice experiment

Abstract

Background: Most adults, and disproportionately fewer African-Americans, have not received herpes zoster (HZ) vaccination despite current recommendations. This study (GSK study identifiers: 208677/HO-17-18066) assessed HZ vaccination preferences among adults aged ≥ 50 years. Research design and methods: In this discrete choice experiment, respondents chose among a 'no vaccine' option and two HZ vaccine profiles, characterized by seven attributes, in a series of choice questions. Random-parameters logit results were used to predict likely vaccine uptake. Subgroup and latent class analysis of African-American's preferences were performed. Results: The preference weight for choosing HZ vaccines over no vaccine was statistically significant among the 1,454 respondents (71.9% whites; 25.2% African-Americans). Out-of-pocket (OOP) cost and vaccine effectiveness (VE) were the most important attributes. The African-American and the non-African-American subgroups had statistically significant differences in preferences (χ 2 = 59.91, p < 0.001), mainly driven by OOP cost and VE. Latent class analysis identified three groups of African-American respondents with systematically different preferences; two comprised likely-vaccinators, with one being more cost sensitive at lower price thresholds, and one likely non-vaccinators. Conclusions: For all respondents, HZ vaccine choices were most sensitive to total OOP cost, followed by VE.

Preferences of pregnant women toward a future maternal Group B Streptococcus vaccine in China: A cross-sectional survey with a discrete choice experiment

“…In previous studies, respondents have shown a negative preference for vaccine price increases. 32 , 34 , 35 In our study, however, the coefficient of preference for vaccine price is positive, which means that pregnant women are willing to take the vaccine at a higher price (though this relationship was not statistically significant), which is consistent with a previous study of influenza vaccine on the elderly. 36 The reason for this finding may be that pregnant women and the elderly are more concerned about the benefits and risks of vaccination and are relatively insensitive to price, but more research is needed to confirm this.…”

Preferences and Willingness to Pay for Herpes Zoster Vaccination Among Chinese Adults: Discrete Choice Experiment

“…The residents preferred to select HZ vaccine with higher protection rate, longer protection duration, less side-effects and lower prices. This has been confirmed in several previous studies about preferences for HZ vaccination in the US 21 , China 23 and other vaccines' acceptance 28,34,45 . Though The positive or negative signs of most of the coefficients in this study were consistent with our prior hypotheses and thus, showed theoretical validity 28 .…”

“…We recruited respondents randomly with acknowledgement after arriving at the health service centers. Eligible respondents were aged ≥ 25 years, living in China, without cognitive impairments and able to read and understand Chinese 21,33 . A pilot study was conducted among 300 residents in Beijing in July 2021 to examine whether the survey was acceptable, well-understood and valid.…”

“…Studies investigating the public's preferences for HZ vaccination are limited and fragmented. Though growing studies have tried to find the main barriers of HZ vaccine acceptance 20 , only three published studies have examined HZ vaccine preferences among older people in the context of developed countries with discrete choice experiment (DCE), two from developed countries 21,22 and one from developing countries 23 . Zhang et al 23 Moreover, it is worth studying adults under the age of 50 because the younger population may affect HZ vaccination by influencing their parents who are probably over 50 years old and the study may provide an opportunity to compare the differences of preferences for HZ vaccination between younger and older population 25 .…”

The COVID-19 vaccination decision-making preferences of elderly people: a discrete choice experiment

“…This result is inconsistent with the existing studies on the public's preference for COVID-19 vaccines 17,20,22 . One recent piece of research also found that people are more willing to undergo vaccination with fewer injection times 23 . According to the health belief model, in this study, the opposite results may stem from the impact of news reports on people's cognition of vaccination 8 .…”