Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments

Wulandari, Luh Putu Lila; He, Shi Yi; Fairley, Christopher K; Bavinton, Benjamin R.; Marie-Schmidt, Heather; Wiseman, Virginia; Guy, Rebecca; Tang, Weiming; Zhang, Lei; Ong, Jason J.

doi:10.1016/j.eclinm.2022.101507

Cited by 27 publications

(18 citation statements)

References 54 publications

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“…Similar to other DCEs in the literature, we use online recruitment strategies. 23 24 Participants are recruited through banner advertisements on the MYDAWA online pharmacy website. To target persons at risk of HIV acquisition, only those who click on HIV self-test kits on the MYDAWA platform see the online recruitment banners.…”

Section: Methods and Analysismentioning

confidence: 99%

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Assessing preferences for HIV pre-exposure prophylaxis (PrEP) delivery services via online pharmacies in Kenya: protocol for a discrete choice experiment

et al. 2023

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IntroductionPre-exposure prophylaxis (PrEP) is highly effective at preventing HIV acquisition, but coverage remains low in high prevalence settings. Initiating and continuing PrEP via online pharmacies is a promising strategy to expand PrEP uptake but little is known about user preferences for this strategy. We describe methods for a discrete choice experiment (DCE) to assess preferences for PrEP delivery from an online pharmacy.Methods and analysisThis cross-sectional study is conducted in Nairobi, Kenya, in partnership with MYDAWA, a private online pharmacy retailer with a planned sample size of >400 participants. Eligibility criteria are: ≥18 years, not known HIV-positive and interested in PrEP. Initial DCE attributes and levels were developed via literature review and stakeholder meetings. We conducted cognitive interviews to assess participant understanding of the DCE survey and refined the design. The final DCE used a D-efficient design and contained four attributes: PrEP eligibility assessment, HIV test type, clinical consultation type and user support options. Participants are presented with eight scenarios consisting of two hypothetical PrEP delivery services. The survey was piloted among 20 participants before being advertised on the MYDAWA website on pages displaying products indicating HIV risk (eg, HIV self-test kits). Interested participants call a study number and those screened eligible meet a research assistant in a convenient location to complete the survey. The DCE will be analysed using a conditional logit model to assess average preferences and mixed logit and latent class models to evaluate preference heterogeneity among subgroups.Ethics and disseminationThis study was approved by the University of Washington Human Research Ethics Committee (STUDY00014011), the Kenya Medical Research Institute, Nairobi County (EOP/NMS/HS/128) and the Scientific and Ethics Review Unit in Kenya (KEMRI/RES/7/3/1). Participation in the DCE is voluntary and subject to completion of an electronic informed consent. Findings will be shared at international conferences and peer-reviewed publications, and via engagement meetings with stakeholders.

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Section: Methods and Analysismentioning

confidence: 99%

“…Prior DCEs assessing PrEP have examined user preferences for dosing regimen, type of PrEP products, side effects, cost, dispensing venue, and support services. [18][19][20][21][22][23] However, this is the first study to assess user preferences for online PrEP (ePrEP) delivery.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Assessing preferences for HIV pre-exposure prophylaxis (PrEP) delivery services via online pharmacies in Kenya: protocol for a discrete choice experiment

et al. 2023

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“…Over the last decade, there has been a surge in studies utilizing PEM to inform strategies to improve the delivery and uptake of HIV prevention and treatment interventions. Several reviews have been published to synthesize the findings of preference research studies related to this topic [3 ▪▪ ,4,5 ▪ ,6]. In a recent systematic review of studies utilizing PEM for HIV prevention and testing interventions (from 1998 to 2020; both intervention design and service delivery), 84 studies used only six methods among the 22 method archetypes identified by Soekhai et al [3 ▪▪ ].…”

Section: The Use Of Preference Elicitation Methods In Hiv Prevention ...mentioning

confidence: 99%

“…Notably, these methods are increasingly being used to understand the market of new HIV prevention and treatment interventions (e.g. long-acting formulations and different drug-delivery mechanisms, such as injectables and vaccines, intravaginal rings, microbicides, implants, and patches) [3 ▪▪ ,4,5 ▪ ,6]. This article will summarize promising available PEM, their use in HIV prevention and treatment implementation research to date, and highlight how they can be used to enhance overall effects using the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework [7].…”

Section: Introductionmentioning

confidence: 99%

A world of choices: preference elicitation methods for improving the delivery and uptake of HIV prevention and treatment

Kerkhoff

Muiruri

Geng

et al. 2022

Current Opinion in HIV and AIDS

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Purpose of reviewDespite the growing availability of effective HIV prevention and treatment interventions, there are large gaps in their uptake and sustained use across settings. It is crucial to elicit and apply patients’ and stakeholders’ preferences to maximize the impact of existing and future interventions. This review summarizes quantitative preference elicitation methods (PEM) and how they can be applied to improve the delivery and uptake of HIV prevention and treatment interventions.Recent findingsPEM are increasingly applied in HIV implementation research; however, discrete choice experiments (DCEs) have predominated. Beyond DCEs, there are other underutilized PEM that may improve the reach and effectiveness of HIV prevention and treatment interventions among individuals by prioritizing their barriers to engagement and determining which attributes of interventions and delivery strategies are most valued. PEM can also enhance the adoption and sustained implementation of strategies to deliver HIV prevention and treatment interventions by assessing which attributes are the most acceptable and appropriate to key stakeholders.SummaryGreater attention to and incorporation of patient's and stakeholders’ preferences for HIV prevention and treatment interventions and their delivery has the potential to increase the number of persons accessing and retained in HIV prevention and treatment services.

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“…Collaboration is critical because true identification of patient cure preferences requires careful experimentation using different approaches such as mixed methods qualitative design, discrete choice experiments (DCE), best worst scaling and human-centred design (HCD). Although mixed methods will deliver in-depth qualitative understanding of patient choices, DCEs will allow stakeholders to weigh different cure intervention characteristics, make trade-offs and select appropriate options [ 58 , 59 ▪ ]. The HCD borrowed from economics and gaining grounds in healthcare and HIV research is an iterative process that narrows the gap between an intervention being planned and end user preferences [ 60 , 61 ▪▪ , 62 ].…”

Section: Advancing the Acceptability Cure Agendamentioning

confidence: 99%

HIV cure: an acceptability scientific agenda

Bonney

Lamptey

Kyei

2022

Current Opinion in HIV and AIDS

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Purpose of review Recent years have seen major investments into HIV cure research, seeking a permanent cure or remission. The purpose of this review is to consider how this important research agenda could be broadened to include issues of acceptability and appropriateness for different populations. Recent findings We discuss how the definitions of cure such as functional cure (remission) or complete cure (viral elimination) could be interpreted differently by various populations. We also discuss the different methods of cure and the importance of including Africa in cure research to ensure that emerging remedies could be trialled and utilized on the continent that bears the brunt of the AIDS pandemic. Summary We propose that the social science research of HIV cure acceptability should be done concurrently with the basic and clinical sciences, to ensure that cure methods consider stakeholder preferences.

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Preferences for pre-exposure prophylaxis for HIV: A systematic review of discrete choice experiments

Cited by 27 publications

References 54 publications

Assessing preferences for HIV pre-exposure prophylaxis (PrEP) delivery services via online pharmacies in Kenya: protocol for a discrete choice experiment

Assessing preferences for HIV pre-exposure prophylaxis (PrEP) delivery services via online pharmacies in Kenya: protocol for a discrete choice experiment

A world of choices: preference elicitation methods for improving the delivery and uptake of HIV prevention and treatment

HIV cure: an acceptability scientific agenda

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