Preferential coordination of ruthenium complex as an electroactive self-assembled monolayer on gold substrate and its application in sensing of dopamine

Toledo, Kalil Cristhian Figueiredo; Bonacin, Juliano Alves

doi:10.1016/j.inoche.2018.10.013

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…This is derived from the chemical/physical instability of the naturally-derived molecular recognition materials (enzymes). In this regard, Bonacin et al recently reported the selective detection of dopamine by a square wave voltammetry (SWV) measurement combined with a ruthenium-complex SAM (Figure 12a) [46]. In this study, a sensing electrode was initially modified by a 4-mercaptopyridine (4mpy) SAM.…”

Section: Electrochemical/electrical Detection Of Analytes For the Achmentioning

confidence: 98%

The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes

Minamiki

Ichikawa

Kurita

2020

Sensors

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Synthetic sensing materials (artificial receptors) are some of the most attractive components of chemical/biosensors because of their long-term stability and low cost of production. However, the strategy for the practical design of these materials toward specific molecular recognition in water is not established yet. For the construction of artificial material-based chemical/biosensors, the bottom-up assembly of these materials is one of the effective methods. This is because the driving forces of molecular recognition on the receptors could be enhanced by the integration of such kinds of materials at the 'interfaces', such as the boundary portion between the liquid and solid phases. Additionally, the molecular assembly of such self-assembled monolayers (SAMs) can easily be installed in transducer devices. Thus, we believe that nanosensor platforms that consist of synthetic receptor membranes on the transducer surfaces can be applied to powerful tools for high-throughput analyses of the required targets. In this review, we briefly summarize a comprehensive overview that includes the preparation techniques for molecular assemblies, the characterization methods of the interfaces, and a few examples of receptor assembly-based chemical/biosensing platforms on each transduction mechanism.Synthetic receptors (i.e., artificial molecular recognition materials) are some of the most suitable platform materials for the development of chemical/biosensors owing to their chemical/physical stability, low cost of production, and their fine-tuning ability to select the required targets [4]. However, the preparation of artificial receptor-based sensors for practical applications is still in its initial stages, since the analyte specificity of most of the artificial materials is generally lower than that of biomaterials (i.e., antibodies and enzymes) [5]. To improve the binding affinity between the artificial receptors and the analytes, complicated synthesis procedures are required. Hence, a simpler way to improve the sensing ability of the artificial receptors should be considered to bring out the attractive features of these materials. To facilitate this, bottom-up integration of the receptors as molecular assemblies is considered as one of the most useful approaches for the construction of selective sensing fields for analytes. Moreover, the sensing features in the artificial receptor-based sensors could be finely tuned by using top-down technologies (e.g., molecular imprinting techniques [6], etc.) because the molecular recognition ability of the receptor assemblies depends on their nanostructures [7]. As aforementioned, the molecular assembly enhances the functions of a single kind of molecule ( Figure 1) [8]. In addition, the driving forces in molecular recognition (i.e., noncovalent interactions) can be amplified at the interfaces such as the boundary portion between the liquid and solid phases [9,10]. Thus, we believe that the installation of artificial receptors at the surface of the sensing portion in selective transducer...

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Section: Electrochemical/electrical Detection Of Analytes For the Achmentioning

confidence: 98%

The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes

Minamiki

Ichikawa

Kurita

2020

Sensors

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“…Particularly, the sensing sensitivity and specificity greatly relies on the embedded sensor materials. Common materials used in the microchips include carbon-based nanostructures, metal oxides, crystalline materials, and their corresponding composites. − Considering the advantages of microfluidics for biosensing, it is thus of great interest and valuable to develop a facile and straightforward strategy that can reliably produce integrated microfluidic devices with novel sensing materials.…”

mentioning

confidence: 99%

Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection

et al. 2023

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Developing functional materials that directly integrate into miniaturized devices for sensing applications is essential for constructing the next-generation point-of-care system. Although crystalline structure materials such as metal organic frameworks are attractive materials exhibiting promising potential for biosensing, their integration into miniaturized devices is limited. Dopamine (DA) is a major neurotransmitter released by dopaminergic neurons and has huge implications in neurodegenerative diseases. Integrated microfluidic biosensors capable of sensitive monitoring of DA from mass-limited samples is thus of significant importance. In this study, we developed and systematically characterized a microfluidic biosensor functionalized with the hybrid material composed of indium phosphate and polyaniline nanointerfaces for DA detection. Under the flowing operation, this biosensor displays a linear dynamic sensing range going from 10 −18 to 10 −11 M and a limit of detection (LOD) value of 1.83 × 10 −19 M. In addition to the high sensitivity, this microfluidic sensor showed good selectivity toward DA and high stability (>1000 cycles). Further, the reliability and practical utility of the microfluidic biosensor were demonstrated using the neuro-2A cells treated with the activator, promoter, and inhibiter. These promising results underscore the importance and potential of microfluidic biosensors integrated with hybrid materials as advanced biosensors systems.

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Porphyrin/MoS2 film for ultrasensitive dopamine detection

Lü

Kong

et al. 2019

Inorganic Chemistry Communications

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Preferential coordination of ruthenium complex as an electroactive self-assembled monolayer on gold substrate and its application in sensing of dopamine

Cited by 6 publications

References 35 publications

The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes

The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes

Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection

Porphyrin/MoS2 film for ultrasensitive dopamine detection

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