Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal

Parajuli, Prahlad; Anand, Rohit; Mandalaparty, Chandramouli; Suryadevara, Raviteja; Sriranga, Preethi U.; Michelhaugh, Sharon K.; Cazacu, Simona; Finniss, Susan; Thakur, Archana; Lum, Lawrence G.; Schalk, Dana; Brodie, Chaya; Mittal, Sandeep

doi:10.18632/oncotarget.6847

Cited by 35 publications

(28 citation statements)

References 81 publications

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“…Several cytokines regulate the NF-κB pathway, and NF-κB also controls the expression of various cytokines, particularly IL-6 and IL-8, which are strongly associated with tumor progression and CSC survival [51,52]. Extracellular IL-6 induces malignant features in stem/progenitor cells from ductal breast carcinoma [33].…”

Section: Discussionmentioning

confidence: 99%

Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

et al. 2020

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Cancer stem cells are responsible for breast cancer initiation, metastasis, and relapse. Targeting breast cancer stem cells (BCSCs) using phytochemicals is a good strategy for the treatment of cancer. A silica gel, a reversed-phase C18 column (ODS), a Sephadex LH-20 gel, thin layer chromatography, and high-performance liquid chromatography (HPLC) were used for compound isolation from Saururus chinensis extracts. The isolated compound was identified as machilin D by mass spectrometry and nuclear magnetic resonance (NMR). Machilin D inhibited the growth and mammosphere formation of breast cancer cells and inhibited tumor growth in a xenograft mouse model. Machilin D reduced the proportions of CD44+/CD24- and aldehyde dehydrogenase 1 (ALDH1)-positive cells. Furthermore, this compound reduced the nuclear localization of the NF-κB protein and decreased the IL-6 and IL-8 secretion in mammospheres. These results suggest that machilin D blocks IL-6 and IL-8 signaling and induces CSC death and thus may be a potential agent targeting BCSCs.

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Section: Discussionmentioning

confidence: 99%

Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

et al. 2020

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“…In human hepatocellular carcinoma (HCC), IL-17E binding to IL-17RB motivates NFκB and JAK/STAT3 pathways to facilitate propagation and self-renewal ability of CSCs, and these beneficial effects could be prevented by specific inhibitors of JAK and NFκB signals (64). Similarly, by NFκB and STAT3 pathways, IL-17-IL-17R interaction in glioma stem cells (GSCs) induces an autocrine and/or paracrine cytokine feedback loop, that may provide an important signaling pathway for the stemness of GSCs (65). In addition to that, the upregulation of IL-17 in gastric cancer results in the transformation of quiescent gastric CSCs into invasive gastric CSCs, from invasion, migration to tumor formation ability (66).…”

Section: Interplay Between Inflammatory Tumor Microenvironment and Camentioning

confidence: 99%

Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)

et al. 2018

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Cancer stem cells (CSCs), which have a close connection with tumor microenvironment, play a pivotal role in tumorigenesis, tumor progression, and metastasis. The inflammatory microenvironment is an essential component of tumor microenvironment. In the recent years, many studies have demonstrated that the inflammatory microenvironment induces the initiation of tumors, and contributes to the process of the progression of tumors, as well as metastasis. In this review, we summarize the relationship between CSCs and inflammatory components, such as inflammatory cytokines (IFNs, TNF, IL-6, IL-17) and inflammatory cells (myeloid-derived suppressor cells, tumor-associated macrophages). To illuminate the key factors that exert important actions in the tumor process would be important to improve the clinical outcome of the treatment for different types of cancer.

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“…176 Additionally, atorvastatin inhibits IL17R expression on glioma cell lines in vitro, 177 which is thought to be a keystone proglioma stem-cell effector. 178 TGFβ (specifically TGFβ 1 ) is also produced by GAMs/TAMs, and this source of cytokines has been shown to induce MMP9 expression and invasiveness of glioma stem cells in their local niche. 179 Finally, investigators are cautioned to interpret semantics carefully when reading such reports as Bayat et al's description of IL17RA inhibition as "anti-inflammatory": 177 proinflammatory is likely the desired effect in this specific setting, as it is immunosuppression and escape from immunosurveillance effected by GAMs/TAMs that supports progression of malignant cancers, including high-grade gliomas.…”

Section: Glioma-associated Microglia/macrophagesmentioning

confidence: 99%

Current insights into matrix metalloproteinases and glioma progression: transcending the degradation boundary

Pullen¹,

Pickford²,

Perry³

et al. 2018

MNM

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Glioblastoma multiforme (GBM) remains one of the most deadly cancers, with modest advances in overall survival despite significant improvements in imaging, surgery, and molecular genomic understanding. The highest-grade glioma, GBM is a primary brain cancer that is molecularly heterogeneous among patients and even within the same patient. Key hallmarks include glioma-cell invasion, angiogenesis, and therapeutic resistance. While once considered a major player in glioma invasion, members of the MMP family are also associated with other key pathological hallmarks of glioma. Investigations into understanding MMP function in GBM were slowed due to the failed MMP-inhibitor trials for GBM in the 2000s. In contrast, the field of MMPs in other brain pathologies has flourished in such areas as traumatic brain injury, multiple sclerosis, and stroke. In the past decade, the increase in publicly available data sets documenting patient-biopsy molecular information has empowered laboratory investigations into the spectrum of genomic, transcriptomic, and proteomic changes associated with glioma, including MMPs. In this review, we selected one of these data sets to illustrate a small sample of information that can be obtained from such analyses. Combined with recent reports on the use of MMP-cleavable peptides for imaging and the multifunctionality of MMPs, including intracellular nonproteolytic actions in various cell types, this paves the way for new avenues of MMP research. Understanding the function of MMPs in host-tumor interactions both spatially and temporally during tumor progression and in response to treatment will be crucial for the advancement of targeting specific MMPs in GBM. The opportunities to explore MMP regulation, expression, and function further in GBM have never been so great with progress in modern bioinformatics and molecular techniques, and it is hoped that advancements will translate in some way to patients diagnosed with GBM.

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Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal

Cited by 35 publications

References 81 publications

Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)

Current insights into matrix metalloproteinases and glioma progression: transcending the degradation boundary

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